Gavin Sathianathan

🚨🇧🇦 Bosnia and Herzegovina have announced their first-ever World Cup squad. 😍 And the promo video is absolute cinema. 🔥

@JuliaHB1 The Sarajevo Film Festival was first held in 1995, during the Siege of Sarajevo

So impressive that they can do this, what with all the genocide and famine going on around them. The struggle is real ✊🏻

What exactly is energy? Today on The Science and Experience of Energy, @niroshajmurugan discusses the physical nature of energy and how fundamental laws of physics are relevant to our understanding of physiology and medicine. Viewing the body through a biophysical lens as a system that transforms energy can provide new insights and change our approach to health and healing. martinpicard.substack.com/p/what-we-miss…

why everyone wants to go to japan let's go to bosnia

ok actually insane paper published yesterday a research group in Korea built a gene switch you can control wirelessly using electromagnetic fields they exposed mice to 60 hz EMF (same frequency as your wall outlet) using a pair of large coils that generate a uniform magnetic field around the animal, for cyclic 3-day on / 4-day off pulses they showed this could: - activate OSK to do epigenetic reprogramming in progeroid and aged mice, extending lifespan and reversing aging markers across multiple tissues - conditionally switch on mutant amyloid genes only in aged mouse brains, letting them separate aging effects from amyloid effects to study AD biology in a way previous models couldn't no drugs, no impacts, just a magnetic field from outside the body

A group of young people from Srebrenica have created a video production dedicated to the young Bosnia and Herzegovina national team player Esmir Barjaktarević, who is originally from that city. The video is titled: "They tried to bury us, but they didn't know that we are seeds." (Klix.ba) #FIFAWorldCup Video / editing:Ahmedin Đozić, Redžep Uštić Organization: Edin Ikanović Script: Nedim Jahić

Exercise is good for the brain. But why? This morning in The Science and Experience of Energy we explore the effects of exercise on brain mitochondrial. And why making more mitochondria might in part be why moving keeps our brain healthy. martinpicard.substack.com/p/mitochondria…

Psilocybin neurologically weakens the brain circuits that keep you stuck in the same thoughts, and we can now see exactly how. In December 2025, the Kwan lab at Cornell published a study in Cell that mapped, for the first time, how the brain rewires post-psilocybin. You might recognize the Kwan lab. In 2021, they were the first to show that psilocybin grows new dendritic spines in the frontal cortex within 24 hours of a single dose. That study proved psilocybin physically changes brain structure. This new one answers the question it left open: where do those new connections actually go? The method was as creative as the findings. They gave mice psilocybin, then injected an engineered rabies virus into the frontal cortex a day later. Rabies evolved to jump from neuron to neuron across synapses, which is why it’s so deadly. The researchers turned that into a feature, modifying the virus to tag every connected neuron with fluorescent proteins instead of killing them. Then they imaged the entire brain. For too long in this field, psychedelic-induced neuroplasticity has been a picture painted in broad strokes. Now, we finally have evidence for the fact that psilocybin selectively weakens the feedback loops where the cortex talks to itself in circles. These are the circuits associated with rumination, the repetitive negative thought patterns that define depression and anxiety. At the same time, psilocybin strengthens the pathways connecting sensory perception to subcortical action regions, likely leading to stronger connection and responsiveness to the world around you. But the finding that matters most for practitioners is this: this rewiring process is activity-dependent. The neural activity happening during the psilocybin experience determines which specific circuits get rebuilt. The researchers proved this by chemically silencing one brain region during the session; then, the expected rewiring pattern in that region changed completely. What's happening in your brain while you're on psilocybin is literally directing the construction.

SUNLIGHT PASSES COMPLETELY THROUGH YOUR BODY AND YOUR MITOCHONDRIA ARE RESPONDING. 🧵 A recent paper in Nature: Scientific Reports (Jeffery et al. 2025) demonstrates that near-infrared wavelengths from sunlight can be measured on the opposite side of the human thorax after passing completely through it. They placed a spectrometer against the chests of subjects standing with their backs to the midday sunlight and detected transmitted light on the opposite side of the body. The sunlight spectrum spans ~200–3000 nm. Below 600 nm, virtually nothing passes through. Above 600 nm, transmission climbs steadily, peaking between 800–875 nm, a biological transparency corridor sitting between the two dominant tissue absorbers: hemoglobin and water.

Hundreds of scans hint at how substances such as psilocybin, LSD and ayahuasca alter connections between key areas of the brain go.nature.com/4tzwLVX

Jubilant scenes for Bosnia and Herzegovina after qualifying for the World Cup 🎉

WE ARE AT THE WORLD CUP!!!!!!!

This is a bigger problem than most patients and much of the industry realises, and something we've spoken about behind closed doors for a very long-time now. Has no-one in the UK industry learnt from the scandals plaguing the 🇦🇺 Australian market, with singular doctors prescribing exorbitant amounts of medical cannabis under 'shared care' regimes? Can anyone justify it's safe? ➡️ abc.net.au/news/2025-05-1… We know of the top prescriber, we know the clinics involved in this mess - we have been told of independent investigations attempting to ascertain legal proof of a medical specialist/consultant patently prescribing outside of their speciality, and against regulations. We've been told affirmative evidence was gathered, and we've been told the CQC and GMC have been informed. To those in the industry wishing to blow on the house of cards which is UK #MedicalCannabis, stop pushing your luck – because media scrutiny is long overdue. Those companies must: stop abusing shared care as an excuse to use underqualified staff to handle patient's medical interactions; stop trying to turn specialist doctors into 'script monkeys' just approving summarised notes with no true context; stop making a mockery of clinical guidelines for prescribing unlicensed specials; and most especially – stop treating clinics as sales funnels for particular pharmacies, and offer true patient dispensing choice, as is mandated. Clinics are not sales funnels, doctors are not salesmen. A patient owns their physical prescription once written, and can explicitly request where it's directed/sent, even to themselves personally at home. Some clinics attempt to override this in their T&Cs, whereby commercial interests attempt to trump basic and well-established British medical conventions - while also praying on ignorance, and burying terms in small-print without explicit mention upfront. UK medical cannabis is being put at huge risk through unsafe, manipulative and opportunistic practices, from companies attempting to prioritise gaining market share, over safe and sustainable healthcare practices. We repeat to that small corner of the industry, stop pushing your luck, there's only so far you can cut costs on clinician expenses before you make a service unsafe – and that creates risk of governmental intervention affecting all patients. In this instance highlighted below, we rest assured action is being undertaken.

Evidence-based medicine is a blessing of the 20th century. Evidence-based medicine is also a curse of the 20th century. Medical interventions are studied through randomized controlled trials and those interventions are assessed for efficacy and safety on a population level. But no individual quite matches some blended average of every trial participant. Rather, everyone's biology is unique. Sid Sijbrandij just presented the story of his cancer journey at OpenAI forum. When Sid ran out of evidence-based treatment options, he didn’t accept the boundary but rather began treating his cancer like an engineer: - multi-omic tumor profiling at extreme depth - N=1 drug development (vaccines, TCR-T, radioligand therapy) - parallel treatment strategies - continuous measurement (ctDNA, single-cell, immune state) and refinement Rather than protocol-based care, Sid built a learning loop. Maybe the future of medicine in a world where gathering and interpreting data gets cheaper and cheaper looks more like a loop. Thanks for sharing @sytses and @jacobjstern !

The science is finally catching up. Red light therapy isn’t just another wellness trend. It’s a window into how light directly interacts with human biology. From helmets to full-body systems, people are investing in long-wavelength light for one reason: energy at the cellular level. Beneath the hype, the mechanism is simple—but powerful: Light → mitochondria → ATP → function When you support the mitochondria, you don’t just “feel better”—you change how your body produces, manages, and sustains energy. And that’s where things get interesting. Because this isn’t about quick fixes or surface-level benefits. It’s about biological leverage—tapping into the systems that drive recovery, resilience, and longevity. The future of health isn’t just chemical. It’s photonic.

The heart is not a pump. Or rather, it is a pump in the same way that a smartphone is a flashlight. Yes, it performs that function. But it is so much more. The heart possesses its own intrinsic nervous system, containing approximately 40,000 sensory neurons, called sensory neurites, that form what cardiologists now call the heart's "little brain". The heart generates the largest electromagnetic field in the body. Its electrical field is approximately 60 times greater in amplitude than the electrical activity generated by the brain. The magnetic field produced by the heart is more than 100 times greater in strength than the field generated by the brain and can be detected up to three feet away from the body in all directions using SQUID-based magnetometers. HeartMath Institute research has demonstrated that the timing between pulses of the heart's magnetic field is modulated by different emotional states, and crucially, that these magnetic signals have the capacity to affect the physiological systems of individuals around us. This is not metaphor. The heart broadcasts electromagnetic information about your emotional state into the environment at the speed of light, and the nervous systems of other people act as antennae, tuned to and responsive to these signals.

Mitochondria are not powerhouse. Energy is neither created nor produced in mitochondria. Energy is transformed, always, through resistance. The analogy of mitochondria as a powerhouse is deeply misleading, and really restricts the spectrum of things you can consider Nick Jikomes, PhD: "So the energy is being transformed, as you said, Martin, it's not being created out of nowhere. Correct?" Martin Picard, PhD: "Yeah. We often, kind of in common parlance (and even in undergrad text) you'll see 'energy is produced.'" Nirosha Murugan, PhD: "Or 'created.'" Martin Picard, PhD: "Yeah. 'Energy is created, energy is produced in mitochondria.' Energy is not produced. Energy is not created. Energy is transformed, always, through resistance. "The analogy of mitochondria as a powerhouse is deeply misleading, because it simplifies this beautiful transformative organelle into like a unifunctional unit, like a little machine, which I think clouds this analogy. Analogies are so powerful, and they really restrict the spectrum of things you can consider, kind of entertain, once your mind is set on 'mitochondria are powerhouse.' "So I always encourage our trainees and anyone I get to talk to mitochondria about that that powerhouse analogy is really expired, and the more we continue using that term the more we do a disservice to the new, next generation of students and people who come into thinking about mitochondria." @MitoPsychoBio & @niroshajmurugan with @trikomes @ 27:40–28:51 (posted 2025-10-29) youtu.be/GiwDfsIgziA&t=…

The MiSBIE study was designed to understand if mitochondria and energy drive mind-body processes. It is one of the hardest, most valuable, and stimulating project we've ran. In this piece, we give an overview of the main questions, design elements, and snippets of what we've learnt so far. Thanks to our sponsors: The Wharton Fund, NIMH, and @BaszuckiGroup @janellison martinpicard.substack.com/publish/post/1…

Be prepared, there is a small chance that our horrendous leadership could unknowingly lead us into World War III.

Instinct Brothers and Relativity Acquisition Corp. Forge Path to Public Markets in $242 Million Regenerative Medicine Deal beijingtimes.com/business/2026/…