Gerrit M. Große

At biostroke.org, we sat together and thought about what needs to be done to advance #multidisciplinary #stroke #biomarker research in a pragmatic and meaningful way. This @TheLancetNeuro paper summarizes what we came up with. sciencedirect.com/science/articl…

@Dr_No_Charite Important data!!

Check out this new multicenter analysis on #ICH without early clinical deterioration after #EVT in #AIS: rethinking the "asymptomatic" label academic.oup.com/esj/article/11…

#ESOC2026 introduces a dedicated Neurointervention track: a focused, non-parallel programme with hands-on thrombectomy workshops & joint sessions with @esmintsociety, @svinsociety, @EANSonline50 & CSA. Programme & Registration: ow.ly/V1h150Y8IOa #Stroke @FishingNeurons

New AHA acute stroke guidelines are out!

Late breaking abstract submission for #ESOC 2026 is still open Submit your large clinical trial, ongoing trial or late breaking abstract now. 🔗Submit your abstract by 12 Feb: ow.ly/Rr7e50XTY7s #StrokeResearch #Neurology #StrokeScience #VoiceOfStroke #Stroke #StrokeCare

Before switching to holiday mode, use the weekend to prepare your #ESOC2026 abstract: 🔗ow.ly/oc6W50XBLCH Abstract deadlines are coming up on 7 January. Your expertise matters — make it visible. #Stroke #VoiceOfStroke #Neurology

🚨#EVT for #MeVO #DMVO- what’s known and what’s next🤔🤯 check out this @CO_Neurology review by Antonio Ciacciarelli & @UPensato !! 📝 journals.lww.com/co-neurology/a…

Pleased to share our new review on stroke biomarkers published in Current Opinion in Neurology: @jessicaseetge @UniBasel journals.lww.com/co-neurology/f…

🩸A CT-Neuropathology Accuracy Study for Diagnosis of Cerebral Amyloid Angiopathy 🧠-> This study supports histopathological examination for the diagnosis of CAA in patients who suffered lobar ICH undergoing surgical treatment. neurology.org/doi/10.1212/WN…

@replynickel @YouTube Also one of my favourite classics: youtu.be/NjVNWNdaAeI?si…

RIP Jack de Johnette, with Brecker, Calderazzo, Metheny, Holland) - Tokyo 1997 youtu.be/O4Ya8iBh8is?si… via @YouTube

Reperfusion in #stroke can be beneficial, futile, or harmful. A better understanding of the pathophysiology and overall prognosis can inform our decision-making. @StrokeAHA_ASA @American_Heart @johanna_ospel ahajournals.org/doi/full/10.11…

The stroke field had major developments since 1993 when the TOAST criteria were proposed. We need move on to a different system that incorporates new mechanisms/tools/testing and standardizes the minimum workup. Introducing ISPS25 #stroke #WSC25 #meded ahajournals.org/doi/10.1161/ST…

Special Report by @ShadiYaghi2 et al.: The ISPS25 classification system creates a new framework to understand #stroke etiology and permit targeted treatments and rational randomized trial design for various ischemic stroke subtypes. #AHAJournals #WSC2025 ahajrnls.org/472BjvF

Could the Parkinson’s drug levodopa prime the brain to respond better to intensive rehabilitation following a stroke or injury? Enter the idea: Let’s give dopamine pills after a stroke? Spoiler alert: This new large, randomized trial published in JAMA revealed no added benefit in recovery. The authors were hoping for neuroplasticity. Neuroplasticity means the brain’s ability to rewire itself and to form new connections. Engelter and colleagues describe the results of the ESTREL randomized clinical trial which tested whether adding levodopa to rehabilitation would improve recovery after stroke. Key Points: - The ESTREL trial included 610 folks w/ stroke across 13 stroke centers in Switzerland. - The folks in the trial were randomized to levodopa or placebo and of course both got standardized rehabilitation. - At 3 months there was no significant difference in motor function recovery between the levodopa and placebo groups. - There was only a 0.9-point adjusted mean difference on the 100-point Fugl-Meyer scale. - Safety outcomes showed no meaningful differences between groups. - There were similar rates of serious adverse events and of mortality (death). My take: The idea of using levodopa to boost dopaminergic signaling in the brainand to enhance motor recovery is not new. It is cool these authors had the courage to put it to a test. Though it didn’t work, how might it have worked? We don’t know, but we should think about motor learning, neuroplasticity, synaptic plasticity and how reward, as well as motivation, may play a role. Here are 5 points that resonated w/ me. 1- Stroke recovery depends heavily on task-oriented intensive rehabilitation. 2- Adding levodopa to standard therapy did not boost recovery outcomes in this large and carefully run study. 3- Folks receiving levodopa had similar safety profiles compared w/ placebo. 4- Prior smaller studies hinted at possible benefits, however this large trial shows no ‘routine role’ for levodopa in stroke rehab. 5- The search for effective drugs to enhance brain repair after stroke continues. Could we use levodopa for other symptoms and syndromes beyond movement disorders? jamanetwork.com/journals/jama/… @ParkinsonDotOrg @FixelInstitute @SfNtweets @HeartandStroke

🧠❄️ Deadline coming up. Apply now for the 13th ESO–ESMINT–ESNR Stroke Winter School. Apply now to take part in an unparalleled training experience. Apply until 30 September🔗 ow.ly/etWk50WECke #StrokeCare #StrokeEducation @inselgruppe #Stroke

📢 Save the Date – Abstract Submission for #ESOC2026 Abstract submission will open earlier than in previous years. Plan ahead & prepare your research: 🗓️ Opening: 8 October 2025 🗓️ Deadline: 7 January 2026 🔗 ow.ly/RCAR50WOXRO #VoiceOfStroke #Stroke #Neurology

⏰Deadline Today! Apply to ESO’s Emerging Leaders Programme! ESO is seeking the next generation of visionary leaders committed to advancing stroke prevention, treatment, and advocacy worldwide. 👉 ow.ly/soVC50WaKJF #Stroke #Neurology #StrokeTwitter

@FrontNeurol @UniBasel_en @DKFBasel

Happy to share our article collection “Blood-based cellular and molecular biomarkers in acute ischemic stroke and hemorrhagic stroke, Volume II” exploring advances in inflammatory, metabolic, and damage biomarkers—addressing stroke diagnosis, prognosis, and individualized care.🧠

Mark your calendars now! 📅 Save the Date: 6-8 May 2026, #ESOC2026 in Maastricht We can't wait to bring you more details this autumn, so stay tuned for updates!🔗 eso-stroke.org/esoc2026/ #Neurology #Stroke #VoiceOfStroke