Brian Mac Grory

In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia | New England Journal of Medicine nejm.org/doi/full/10.10… @kewatson

Excited to share two papers that we hope will give readers a framework for reading and conducting observational studies that are intended to compare treatments. First, a systematic approarch for comparing cardiovascular devices using observational data. ahajournals.org/doi/10.1161/CI…

In-Hospital Stroke Quality and Outcomes in the Mechanical Thrombectomy Era: Get With The Guidelines-Stroke, 2016 to 2023 | Stroke ahajournals.org/doi/10.1161/ST… @American_Stroke @StrokeAHA_ASA @AHAScience @AHA_Research #GWTG @brianmacgrory @ShumeiManMD

Stroke Month 2026 During the first 20 years, Get With The Guidelines-Stroke participation was associated with sustained improvement in evidence-based care and outcomes for ~8 million patients with stroke and TIA in the US doi.org/10.1161/stroke…

#QuadTherapy for #HFrEF is essential But is it enough? Even when prescribed 4 pillars, patients w/ HFrEF face very high residual risk of death & HF🏥 🚨New #GWTG_HF data putting HFrEF risk in perspective. @gcfmd @JavedButler1 @DukeHFDoc @JAMACardio jamanetwork.com/journals/jamac…

HF Care Differs Among Asian Subgroups in the US tctmd.com/news/hf-care-d… @NilayShahMDMPH @AHAScience @JACCJournals #GWTG

Delayed hospital arrivals are more prevalent among Asian, Black, and Hispanic patients, but EMS transportation times are shorter Race‐ and Ethnicity‐Specific Hospital Arrival and EMS Activation Times by US State for Ischemic Stroke | JAHA ahajournals.org/doi/10.1161/JA… @AHAScience

The AHA Target Stroke Phase III (TSIII) Program enhances timely EVT care @brianmacgrory @DCRInews @gcfmd @HeartNews @Braindoc_MGH @k_sauser @mayank_G0 @AshuPJadhav @VCI_EricSmith @AmeerEHassan @Akboehme @ASouthStrokeDoc @CerebrovascLab @JayBLusk ahajrnls.org/3Y8KQvU

Association of Component Strategies of the Target Stroke Phase 3 Nationwide Quality Improvement Program With Accelerated Door-to-Puncture and Door-In-Door-Out Times for Ischemic Stroke Endovascular Thrombectomy in the United States ahajournals.org/doi/10.1161/CI… @AHAScience @DCRINews

📣@DukeMedSchool seeks a nationally recognized #anesthesiologist for chair of a top ranked department, Duke Anesthesiology. This is a unique opportunity to lead a renowned team known for excellence in patient care, research and education. 🔗Apply by 10/27: tinyurl.com/chairsearch

Should dual energy CT head be offered at every comprehensive stroke center? I think so. Here's how it can change management (🧵1/3). 60s male presents after fall with altered mental status. Initial non-contrast CT head reveals a left frontal lobe ischemic infarct:

Here is a concrete example where overcalling IIH can negatively affect patient care. Late teens patient with complex medical history presenting with headaches. Empty sella and prominent optic nerve fluid? How would you call it?

Intracerebral Hemorrhage Outcomes After Reversal of Subtherapeutic Warfarin: Analysis of Data From GWTG-Stroke | Stroke ahajournals.org/doi/10.1161/ST… @DCRINews @AHAScience @brianmacgrory @YingXian21 @StrokeAHA_ASA @HeartNews @CDCHeart_Stroke

Hospital Implementation of Endovascular Thrombectomy and Health Equity in Acute Stroke Outcomes | Stroke ahajournals.org/doi/10.1161/ST… @AHAScience @HeartNews @CDCHeart_Stroke #GWTG @DCRINews @brianmacgrory @Braindoc_MGH

The ORBIT Interdisciplinary Hub at Duke University is hiring a post-doctoral associate with a background in biostatistics and data science. Please feel free to direct message me for further details. Applications can be submitted here: careers.duke.edu/job/Durham-POS…

Optimal endovascular management of tandem occlusions remains controversial. Krothapalli et al. provide an updated review of the existing data and ongoing clinical trials. Relevant unanswered questions include optimal antithrombotic therapy, device selection, and thrombectomy in dissection-associated tandem occlusions and posterior circulation tandem occlusions. bit.ly/470XmTQ @nkrothapalli4 @JeremyHeitMDPHD #EVT

Educational Strategies for Clinical Supervision of Artificial Intelligence Use | New England Journal of Medicine nejm.org/doi/full/10.10…

“steroidal MRAs have little to no effect on CV mortality in patients requiring dialysis” Safety and efficacy of steroidal MRAs in patients with kidney failure requiring dialysis: a systematic review and meta-analysis of RCTs - The Lancet thelancet.com/journals/lance…

Our study on radial artery PCI use in the US, out in European Heart Journal - Radial PCI now over 60% of all PCI - Significant provider variation remains - In IV analysis, radial reduced death and major bleeding, w small Increase in stroke @SmithBIDMC tinyurl.com/vy3f83ek

Global Trends in Ischemic Heart Disease-Related Mortality From 2000 to 2019 sciencedirect.com/science/articl… @JACCJournals