Proud to share this publication by our postdoc, Shweta Devi! It offers new insights into the interaction capabilities of the TPR domain to EEVD-like motifs in nonchaperone proteins.
jbc.org/article/S0021-…
English
Gestwicki Lab
147 posts
Gestwicki Lab
@GestwickiLab
The Gestwicki Lab @UCSF uses #chemicalbiology and #biochemistry to understand the #proteostasis network. This account is student run.
Katılım Temmuz 2019
263 Takip Edilen1.1K Takipçiler
Excited to share the work done by @taiawu and Zach Gale-Day on DSFWorld: an online open-source software that streamlines the planning and analysis of DSF experiments!
onlinelibrary.wiley.com/doi/10.1002/pr…
English
Interested in learning how dyes might help in characterizing protein activity?
We're excited to share the development of a protein-adaptive DSF platform (paDSF), a dye-based method used to interrogate stability, dynamics, and ligand binding!
go.nature.com/4ajNRNp
English
Gestwicki Lab retweetledi
First woman to graduate from MIT was a chemist. She applied chemistry to issues like nutrition - a pioneer ahead of her time in many different ways #WomenInSTEM
Massachusetts Institute of Technology (MIT)@MIT
Ellen Swallow Richards became MIT’s first female graduate when she earned her BS in chemistry on May 31, 1873 — 150 years ago today.
English
We’re thrilled to have Nick joining us!
Scripps Research Graduate Program@ScrippsGradPrgm
An alum of Prof. Jeff Kelly's lab, Nicholas Yan looks forward to a postdoc position in @UCSF's @GestwickiLab and @SouthworthLab, where he'll use cryo-electron microscopy to explore the structural basis of small molecules that target amyloid fibrils. More: scripps.edu/2023grads
English
So great to see @GestwickiLab honored in this excellent group. @KiesslingGroup is super proud to see all of your exciting approaches to #proteostasis
proteinsociety@ProteinSociety
We are thrilled to recognize our 2023 Award Winners: Dr. Arthur Lesk, Dr. Mei Hong, Dr. Patricia Clark, Dr. Polly Fordyce, Dr. Jason Gestwicki, Dr. Renã Robinson, Dr. Kevin Gardner and Dr. Elena Conti. See you in Boston! proteinsociety.org/protein-societ…
English
Congratulations to our amazing postdoc @proteins_emma on winning a poster award at the Protein Folding Dynamics Gordon Research Conference!!! It’s a well-earned testament to her brilliance & creativity!
English
Huge congratulations to @CarolynBertozzi !!! What a well deserved honor.
The Nobel Prize@NobelPrize
BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
English
Gestwicki Lab retweetledi
As part of the #QBIChemBio22 Symposium today, @jadoudna, Nobel Laureate, co-inventor of #CRISPR-Cas9 & Professor at @UCSF/@UCBerkeley will participate in a Twitter Space hosted by Jason Gestwicki. Tune in at 1:30 PT to hear about her work!
qbi.ucsf.edu/twitter-space-…
English
Gestwicki Lab retweetledi
Jumping around the mutation alphabet to hit cancer! Our new work covalent targeting of KRAS G12S is online: nature.com/articles/s4158… Interested in more? The Zhang lab (thezlab.org) at @UCBerkeley is recruiting:)
Kevan Shokat@kevansf
#G12S The Next #KRAS oncogene targeted by covalent chemistry by @bignerdzzy who just started his lab @UCB_Chemistry (thezlab.org). Next up G12R. #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…
. @UCSFCancer @HHMINEWS @UCSF English
Gestwicki Lab retweetledi
Chaperones are needed for so many processes! How do you make process-specific or disease-specific chaperone inhibitors that are not generally toxic? A great collaboration with @GestwickiLab shows the way...cell.com/cell-chemical-…
English
Gestwicki Lab retweetledi
…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome!
cell.com/cell-chemical-…
English
It was fun to be a part of this exciting work!
Arun Wiita@apwiita
…and another 1! 2nd paper in 1 wk @idferguson. Collabo w @gestwickilab @CellChemBiol: allosteric HSP70 inhibitors overcome proteasome inhibitor resistance in #myeloma #mssm. #proteomics finds surprising mechanism: block HSPA9 & destabilize mitoribosome! cell.com/cell-chemical-…
English
Gestwicki Lab retweetledi
I concur. I confirm that new PIs will do everything to make their mentees successful! I contend that other hashtags are also cool. I also confess that I’m a new PI @UCB_Chemistry and we are recruiting thezlab.org
English
Gestwicki Lab retweetledi
Happy to share the @biorxivpreprint for my first bit of work w/ @aliceyting. Together with @heegwangroh, we built a simple and versatile single-component luminescent biosensor for detecting the SARS-CoV-2 spike protein.
biorxiv.org/content/10.110…
English
Very insightful and beautiful review on Hsp70 by @GestwickiLab A must-read for everyone in the field!
Gestwicki Lab@GestwickiLab
Check out our latest review article on non-canonical Hsp70 interactions—out now in Cell Stress & Chaperones! With the recent explosion of studies mentioning them, @oletaknowsstuff & Jason thought this timely. We hope it inspires new important research! link.springer.com/article/10.100…
English
Check out our latest review article on non-canonical Hsp70 interactions—out now in Cell Stress & Chaperones! With the recent explosion of studies mentioning them, @oletaknowsstuff & Jason thought this timely. We hope it inspires new important research! link.springer.com/article/10.100…
English
@MartinUCSF @tauCWOW @SinaiBrain @GeschwindLab @dlswaney @grinberg_t @timschang @TheBiocheminist Congratulations!!!
English
Gestwicki Lab retweetledi
Excited to co-direct the Tau Center Without Walls @tauCWOW with Alison Goate @SinaiBrain and @GeschwindLab, working with awesome colleagues @dlswaney @grinberg_t @timschang @TheBiocheminist and wonderful trainees!
Tau Center Without Walls (CWOW)@tauCWOW
Projects led by our PIs will use multiomics & functional genomics #CRISPR screens to understand molecular & cellular differences in gene expression & cell function due to H1/H2 haplotype inversion leading to new therapeutic targets for treating tauopathies geschwindlab.org/cwow/
English