Matthew Q. Clark

New #axolotyl t-shirt available through the @SocDevBio store. Funds support SDB programs. sdb-official-merch.printify.me/product/302770…

DEADLINE APPROACHING! ⏰ Apply to Comparative Developmental Biology by July 28. This intensive two-week laboratory course is designed for graduate students in their second or later year of Ph.D studies and post-docs. 🔗 More info here: go.mbl.edu/CDB

Applications are open for @MBLScience Comparative Developmental Biology Course, Oct 3 - 18, 2026. Application due date: July 28, 2026. @SocDevBio @intlsocdiff @SICB_ @SSRepro bit.ly/4eYkbeC

Using more than 1.4 petabytes of electron microscopy (EM) imaging data, researchers generated a nanoscale-resolution reconstruction of a millimeter-scale fragment of human cerebral cortex, providing an unprecedented view into the structural organization of brain tissue at the supracellular, cellular, and subcellular levels. ⁠ ⁠ The human brain is a vastly complex organ and, to date, little is known about its cellular microstructure, including the synaptic and neural circuits it supports. Disruption of these circuits is known to play a role in myriad brain disorders. Yet studying human brain samples in such great detail comes with a host of challenges, ranging from technological limitations to the availability and preservation of tissue samples from healthy individuals. ⁠ ⁠ In a 2024 Science study, researchers performed a high-resolution EM reconstruction of the ultrastructure of a cubic millimeter of human temporal cortex. According to the authors, the reconstruction contains roughly 57,000 cells, about 230 millimeters of blood vessels, and nearly 150 million synapses, comprising 1400 terabytes of data. The authors generated a three-dimensional reconstruction of nearly every cell and process in the cubic millimeter sample and developed a freely available tool for visualizing and analyzing the vast dataset.⁠ ⁠ Learn more on #WorldBrainDay: scim.ag/41z2OJ4

Today in @Nature we report how AI-guided redesign enhances protein evolution. Integrating ProteinMPNN sequence design with autonomous laboratory evolution, we establish a workflow to engineer enzymes with improved properties over those evolved from natural proteins. Redesigned starting points consistently evolve an expanded fitness landscape, reaching new function with higher activity, specificity, and stability than their natural counterparts. drive.google.com/file/d/1C-QYcx… 1/14

Shaped by a tumultuous childhood, Broad researcher and epigenomic tool-maker Jason Buenrostro pivots to studying the biology of stress and adversity and finding new ways to boost resilience. broad.io/JasonBProfile

Forever a few of my fav fly neurons -- EPG / Compass cells that track heading direction. A steering wheel of sorts! Explore them in @FlyWireNews Codex: codex.flywire.ai/app/view_3d?fi…

Just published yesterday, the #BANC! A full central nervous system (CNS) connectome of a limbed animal enables us to trace sensory-motor arcs and understand how the CNS controls the body. rdcu.be/fncjS #neuroscience @Nature, Video by @quorumetrix, sound on! 1/18

We see our home planet as a whole, lit up in spectacular blues and browns. A green aurora even lights up the atmosphere. That's us, together, watching as our astronauts make their journey to the Moon.

NYE fireworks < neurons expressing iGluSnFR3! Developed at our Janelia Research Campus, iGluSnFR3 is a fluorescent sensor designed to rapidly detect & image glutamate — our brains' main chemical messenger — allowing researchers to observe (dazzling) neural communication as it happens. 🎆 Credit: Abhi Aggarwal and collaborators

Paul Maddox, UNC professor and cancer researcher, announces run for Congress blueridgenow.com/story/news/loc…

Vote for Paul Maddox — Donate via ActBlue #northcarolina secure.actblue.com/donate/paul-ma…

Please RT @hhmi_science #CechFellows Summer Undergraduate Research Experience - 9 weeks mentored research in an HHMI lab, $15K stipend, deadline to apply is 2 weeks away. See you next summer!

@HHMINEWS Summer Undergraduate Research Experience - #CechFellows named in honor of Prof Tom Cech Deadline to apply: 12/22/2025 Spend 9 weeks in a paid, mentored biomedical research experience in an HHMI lab. See you next summer!!! hhmi.org/programs/cech-…

"He's an unbelievable human being." RJ Peete, a longtime clubhouse attendant for the Dodgers, embodies what it truly means to be family within the clubhouse. Tom Rinaldi shares the inspiring story of how RJ has defied expectations and found purpose with the team.

2025 Grass Fellowships at the Marine Biological Laboratory - Apply Now! Deadline: November 15, 2024. grassfoundation.org/application-po…

The FlyBase situation has made the national news nbcnews.com/science/scienc…

Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.

From a vision in 2011 to 14K+ members worldwide, JKScientists continues to mentor, guide & inspire. Presenting our 2024–25 Annual Report—thanks to our board, coordinators, volunteers & students for making it possible. Together, we shape brighter futures. shorturl.at/b5bEG

Here's why I think there is reason to be bullish on U.S. STEM education. doi.org/10.1093/geneti… #STEM #STEMEducation