Donghoon Lee

I’m thrilled to share one of the largest single-cell transcriptomic atlas of the human DLPFC with over 6.3M nuclei from 1,494 unique brain donors. Collaboration with @MKoutrouli Nick @g_e_hoffman @JaroslavBendl John @panos_roussos and #PsychAD Consortium doi.org/10.1101/2024.1…

Congratulations again to the award recipients of the third annual Martha Ondrey Junior Investigator Prize! #ROSMAP2026 #ROSMAP26

With the generous support of Frank Ondrey, MD, PhD, the RADC is pleased to present the 2026 Martha Ondrey Junior Investigator Prize to Donghoon Lee, PhD. Dr. Ondrey presented the award.

Now out in @Nature: Biological insights into schizophrenia from ancestrally diverse populations. With @MountSinaiPsych @SinaiBrain @SinaiGenetics @CDNeurogenomics @POPGEM_Lab #MillionVeteranProgram and collaborators across consortia. Read: rdcu.be/eZ7he

PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.

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Amazing work by @TerezaClarence @JaroslavBendl @XuanCao09514634 and many co-authors!

I want to acknowledge the supports from @panos_roussos @ReneKahn @EricJNestler and many many members from the @CDNeurogenomics and @SinaiBrain to get the lab up and running. Please visit anglab.org for openings.

🎉 Excited to announce preprints from the first #PsychAD package! Check out details of our work at Psych-AD.org 🧵 Found out summary of papers below👇

To all #ASHG24 attendees, I’ll be speaking during “Mapping the Brain in Health and Disease” session today. Come join me & hear about the population-scale single-cell cross-disorder atlas. 📍 Room 501 🗓️ Nov 6, 10:45 AM (MT)

Excited to start day 2 of #ASHG24

A wonderful summary of our work!

We are delighted to share our latest findings today in @Nature. We describe cardiogenic regulation of sleep after cardiac injury. “Myocardial infarction augments sleep to limit cardiac inflammation and damage” nature.com/articles/s4158…

Wow. Hopfield model and Boltzmann machine.

Under the auspices of the PsychENCODE Consortium, Dr. @panos_roussos and his colleagues are changing the field with single-cell analyses of brain tissue with schizophrenia and unraveling regulatory mechanisms of brain disease. via @ScienceMagazine reports.mountsinai.org/article/psych2…

The Center for Disease Neurogenomics (CDN) had a successful retreat day. The year 2024 marked the 10-year anniversary of the lab, and we have grown to 67 members. #CDN #retreat

Genetic regulation of cell type–specific chromatin accessibility shapes brain disease etiology - Biao Zeng, @JaroslavBendl, John Fullard, @g_e_hoffman, @Panos_Roussos, et al. @sciencemagazine science.org/doi/10.1126/sc…

PRESS RELEASE: Working under the umbrella of the PsychENCODE Consortium, a team of @IcahnMountSinai scientists, lead by @panos_roussos, has uncovered new insights into molecular biology of neuropsychiatric disease. #ArtoftheBrain image by @jsj8duke 👉tinyurl.com/4ec5jmdd

Recent review article on neuropsychiatric symptoms in Alzheimer's disease highlights the vast areas still to explore and understand, aiming for meaningful improvements in patient treatment sciencedirect.com/science/articl…

Excited to have the #PSYCHENCODE24 papers out. Thanks for the support of @NIMHgov and the effort of multiple colleagues to bring this product to the finish line! science.org/toc/science/38…