gabriel sanchez

@OncoAlert Thank you

OncoAlert Horizons | Focus: Breast Cancer Educational Series 🚨 In this session, we explore: Therapeutic options after CDK4/6 inhibitor + endocrine therapy in HR+, HER2– advanced/metastatic breast cancer, and the emerging role of SERD-based combination strategies in this setting. 👩‍⚕️ Faculty: Dr. Sherene Loi @LoiSher Peter MacCallum Cancer Centre, Australia 🇦🇺 Dr. Elisa Agostinetto @ElisaAgostinett Institut Jules Bordet, Belgium 🇧🇪 The post-CDK4/6 inhibitor landscape in HR+/HER2– advanced breast cancer represents one of the most pressing unmet needs in oncology. While CDK4/6 inhibitors combined with endocrine therapy have firmly established themselves as the frontline standard, disease progression on this backbone remains nearly universal, driven by heterogeneous resistance mechanisms including ESR1 mutations, PI3K/AKT/mTOR pathway alterations, and RB1 loss. This biological diversity highlights the limitations of one-size-fits-all approaches. Next-generation oral selective estrogen receptor degraders (SERDs)—such as elacestrant, camizestrant, and imlunestrant—are reshaping the field. These agents achieve more complete estrogen receptor degradation than fulvestrant, show activity in ESR1-mutant disease, and are being actively evaluated in combination strategies with CDK4/6 and targeted therapies. Together, they are helping shift the post-CDK4/6 setting toward a more dynamic, biomarker-informed treatment paradigm. This OncoAlert Horizons educational series was supported by an unrestricted educational grant from Roche. All content was independently developed and fully controlled by the faculty. OncoAlert Horizons faculty: @LoiSher @JavierCortesMD @BarbaraPistill2 @BianchiniGP @ElisaAgostinett Sybille Loibl Rupert Barsch Francois Clement Didard Cristina Saura Pinging our #BreastCancer Faculty @matteolambe @aftimosp @E_de_Azambuja @DrSGraff @ErikaHamilton9 @double_whammied @maryam_lustberg @raalbany @hoperugo @stolaney1 @LoiSher @SirohiBhawna @jamecancerdoc @JavierCortesMD @JaniceTNBCmets @Prof_Nadia_H @nataliagandur @acampsmalea @FernandoOnco @ElisaAgostinett @to_be_elizabeth @realbowtiedoc @Lucarecco @GaiaGriguolo @JankovicK @MarioBalsaMD @Onco_Cifu88

sometimes we get so preoccupied in our material lives that we forget the very essence of Living, cherishing each moment. Live

@IlanaSchlam @DFCI_BreastOnc 🙏

In 2025, many important and long-awaited studies were published. I included them but kept the algorithms unchanged, as there are open questions about how these data will impact practice, particularly in early and metastatic HER2+ disease and mTNBC. @DFCI_BreastOnc #SABCS25

Hindi na tayo natuto. Tayong mga Pilipino nakaka lungkot. Lahat to kasalanan natin eh. It starts from the individual himself..

@KnightsInvest rugged sadly :(

One of undervalued privacy projects on SOL is $AEGIS 130k mc dexscreener.com/solana/tvmg8jZ…

@DarkHubCrypto @eliz883 Same question.

@eliz883 Eliz how do you really use 0.75 level?

I'll keep things simple for you regarding the $BTC macro trend. If I lose the weekly trend, the cycle will end and we'll see months of weakness. So, let's ignore the unnecessary noise and watch this for the future.

@CryptoNoanGemz @avantisfi Lets go

Desperation @avantisfi 🚀 $AVNT HIGHER 🚀 PRINTING

"MAY MGA INVOLVED PONG SENADOR DITO" Former Bulacan assistant district engineer Brice Hernandez pleads to the House InfraComm not to return him to the Senate as he claims there are senators involved in the anomalous flood control projects. Hernandez was detained in the Senate after being cited in contempt by the Blue Ribbon Committee on Monday. Watch live: youtube.com/watch?v=qc-3oe…

@CryptoGodJohn 0x0?

Round tripped $5 million profit on a bag twice and sold for a loss after holding for 2.5 years Two words: fucking idiot

@pepo_is_fun @Deadfellaz Nice

We’re not into NFTs. But if one day PEPO decides to be… it’s gonna look a lot like @Deadfellaz .

@pepo_is_fun Let's go

America 🇺🇸 🤝 Europe 🇪🇺 finally connectin… not politics, not wars… just green candles n red ones ⚡️ one truth left 👉 $PEPO platform

@AlSdsi @mayaofficialph any updates?

@mayaofficialph Since yesterday can't open crypto icon, I think you have to evaluate you IT team because it seems they're so lousy!

Faster, more secure, and available 24/7 – the new and improved Help Center is now available on the app 💬 To access the Help Center anytime in your app profile, make sure to update your app to the latest version!

@pepo_is_fun gPepo

BIG NEWS PEPO'ls 🚀 PEPO just launched our ultra-exclusive, super-secret, bombastic Discord group: 👇 discord.gg/7rkEDDgYTB Only $999/month for access to: * Totally real alpha unbelievable * Guaranteed 100x pump tokens * Insider calls from our cousin’s friend’s barber First 10 joiners get a free imaginary Ferrari!

@coachmiranda @grok 👍

@CredibleCrypto 🎯

A near 100% gain off my buy zone for $CVX...in a single week. All covered in advance in my last Youtube video- those who watched it were well prepared for this. For some perspective, this is akin to $BTC going from 100k to 200k, and we did it in a WEEK and we still have another 10-20x+ to go by cycle end imo. This is why I keep saying your focus at this time should be on ALTS, the gains you will see on alts moving forward will dwarf the gains you'll see on $BTC for the remainder of this cycle. (This is also why you should be tuning into my Youtube vids!)

@Trader_XO @trader1sz aww too bad kidding ! 😅 . both of your streams and twitter posts good enough!!

@ielsanchez @trader1sz Eh I don’t have one

@Trader_XO @trader1sz telegram link sir please 😅 been following you two since ‘20 more power to you guys

@trader1sz After consistently hearing rave reviews about @trader1sz i decided to take the leap and reach out to him. It's been one of the best decisions I've made! Since teaming up with him, my investments have experienced substantial growth. He’s tested & trusted.

@Trader_XO wick of yearly candle in? Time for upside expansion phase of candle body

@EmperorBTC 👍

Will start a group on Telegram ONLY for people who want to learn Scalping/Swing trading from scratch. Leave a response if you want to be added. It's free but you need to work to learn. Trading only. No Dating or shilling talks allowed.

Time lost

@CryptoGodJohn Venosaur 👍

New arrivals just landed 👀👀