Derek Abbott

Drug targeting human MLKL might focus on preventing the release of the 4-Helix bundle rather than preventing MLKL phosphorylation. 4/4

MLKL prevents further kinase activity of RIPK3 beyond the initial auto-phosphorylation at sites 224 and 227. In humans, Michelle's work shows that the key initiating event in MLKL activation is not phosphorylation but rather a flipping of the 4-helix bundle of MLKL. 3/4

CWRU MSTPstudent Michelle Pan's dissertation is now available online. In this work, Michelle challenged the idea that, in human necroptosis, RIPK3 phosphorylation of MLKL is the main pore-initiating event. 1/3 cell.com/cell-reports/f…

@MikeReiss Great stuff as usual, Mike! Any word on Jedrick Wills? His knee injury might have been mismanaged by the Browns. They tried to convert him from right tackle to left tackle, where he was serviceable, if not more than average. Thoughts on him being a Morgan Moses backup?

Quick-hit thoughts/notes around the Patriots and NFL (Drake Maye Effect; Romeo Doubs' determination; no deadline with A.J. Brown; AVT's "fresh start"; Reggie Gilliam/FB group text; Dre'Mont Jones - a.k.a. "Big Harold"; Jack Gibbens to visit Arizona etc.) espn.com/nfl/story/_/id…

Excited for ⁦@cwrumstp⁩ and new Abbott lab alum, Michelle Pan, to defend her dissertation today! Congratulations to Dr Pan. Look out for her paper coming out in a couple of weeks!

This weekend, my wife and I were very excited to attend our first Beaux Arts Ball at National Jewish Health. Its very inspiring to work at an institution dedicated to finding treatments and cures for immunologic diseases and to work with such a dedicated team. @KathrynTeng

@MaroonBlackPuck Kathryn and I are following from Denver. LETS ROLL US!!!!

Still tied after the second OT headed to the third OT

@SavageSports_ He used to be very good, but the Browns benched him late in the season. Given the state of their OLine, he might be done.

Is this enough of an upgrade at LG?

Pleased to share a new review article focusing on Gasdermin D's role in Pathology spearheaded by Bowen Zhou, a former @cwrumstp student and current Pathology fellow @UHhospitals annualreviews.org/content/journa…

@BishopBarron We pay >$95K a year for my son to attend Dartmouth. Let's see her start with Point #1 first.

There is a great piece in the Wall Street Journal today, written by Sian Leah Beilock, president of Dartmouth College. She acknowledges what many of us have been saying for some time, namely, that our university system has become corrupt, and she proposes commonsense solutions. First, make a university education more affordable. Tuition and costs have become just ridiculous, especially at schools that boast massive endowments. Second, make the investment worth it. Do more to guarantee that graduates actually get jobs. Third (and to my mind most importantly), "re-center education on learning rather than political posturing." Amen! Finally! And fourth (also music to my ears), "emphasize equal opportunity, not equal outcomes." The former is a basic American principal; the latter is dangerous Woke nonsense. I was very gratified to read all of this from an Ivy League university president. Sign of hope.

@JohnStreicher1 @drugmonkeyblog I think I may put PMCIDs in the body of the text describing contributions to science? Without any references, you could just say anything (ie after I completed my career as a top gun fighter pilot and piloted the space shuttle into orbit, I turned my attention to science).

@inflammgenetics @drugmonkeyblog It says you can “refer” to publications in the sections above but not to use full citations. Whatever that means!

Is the consensus on the new online NIH Biosketch that we cannot list manuscripts in the "Contributions to Science" section? @drugmonkeyblog

Shiga toxin-induced cell death—the underlying cause of a potentially fatal renal disease in children—occurs via pyroptosis, not apoptosis as previously thought, and is driven by an intriguing NLRP1->Caspase-3-> gasdermin E pathway. Congrats to Priya's lab! pnas.org/doi/10.1073/pn…

This isn’t the case at National Jewish Health. We are actively hiring to expand our tenure track faculty in Immunology and genomic medicine. linkedin.com/pulse/pulling-…

FDA approves 100th small-molecule kinase inhibitor nature.com/articles/d4157… From the landmark approval of the anticancer drug imatinib almost a quarter century ago, our latest news feature analyses trends in the field of kinase inhibitors, now one of the major drug classes

@BuckSt87 Meanwhile, Vanderbilt beats them all at 21st...

Strength of Schedule as of today: Ohio state 41st UGA 56th Bama 58th Texas A&M 62nd Notre Dame 67th

Came into lab today to do cell culture work and found a lady bug in my hood!!

@LocasaleLab My medical training informs my research, helps me frame questions, enables me to project manage our research projects, and facilitates the linking of concepts between fields. The broad-based education helps - where else do you learn biochemistry, physiology, immunology, etc.?

The physician–scientist track (MD/PhD) in academic medical centers has become one of the great illusions of modern science - a path that promises to unite medicine and science but rarely fulfills either goal. Training stretches on for years as one person is expected to learn two professions at once, and in practice, they seldom master either. Many hold a token clinic for a few hours a week while running labs that produce derivative “translational” research — supposedly aimed at improving patient care. In reality, these efforts seldom advance either basic knowledge or clinical practice in a meaningful way. The personal rewards, however, are significant: MD/PhDs are paid far more than PhDs alone, face far less competition for faculty positions, are treated better by upper administration, and are freed from the full clinical responsibilities of practicing physicians. They also enjoy privileged access to administrative roles in medical centers, journals, and professional societies - positions that often pay handsomely. Yet almost no one has seriously examined whether this track delivers genuine scientific or medical value, or if it merely sustains another bureaucratic layer within an already bloated healthcare system. students-residents.aamc.org/md-phd-dual-de…

At the Alexandra Kay show in the CLE with ⁦@KathrynTeng⁩ !!!!