Puneeth Shridhar, MD PhD

I’m very happy to share I defended my PhD thesis today. Having suffered from🫀heart hypertrophy, pursuing PhD studying the molecular mechanisms of hypertrophy has been nothing short of dream run! I’m forever indebted to my mentor and role model, Jason R. Becker, MD! 1/n

@CMichaelGibson Good data showing Plavix is a great drug. However, ~30% Asians and ~15% Caucasians don’t activate plavix properly (CYP2C19 genetic issue). In elderly frail patients with frequent falls, a big group, aspirin has a role since it is short acting & easy to reverse

HOST-EXAM trial 10-year results: Clopidogrel monotherapy is superior to aspirin for chronic maintenance after PCI, significantly reducing both thrombotic and bleeding events. #ACC26 View slides here: clinicaltrialresults.org/wp-content/upl…

Excited to see @UHouston and @HCAHouston well represented at #ACC2026 by the outstanding Dr. Dhavalkumar Patel @kingwoodIM

@cardiac_md ACC/AHA vs USPSTF: ACC/AHA treats CAC as a risk tool, needing only predictive accuracy + reclassification. USPSTF requires outcome trials (same bar as a therapy), which CAC lacks. CAC moved from IIb→I because it became built into the PREVENT risk calculator & decision pathway

2012 USPSTF: insufficient evidence for CAC 2013 ACC/AHA: Class IIb rec for CAC 2018 USPSTF: insufficient evidence for CAC 2018 ACC/AHA: Class IIa rec for CAC 2019 JAMA review: insufficient evidence for CAC commonly ordered for executive physicals. 2023 ACC/AHA class IIa rec for cac - With no new clinical trial or any compelling evidentiary change, 2026 ACC/AHA: FIVE Class I rec for CAC. Huh? 🤷‍♂️ jamanetwork.com/journals/jama/…

@khurramn1 @purviparwani Feels like a methodology penalty, not a risk‑based one.

Don't understand the dichotomy on this issue in the cholesterol management guidelines. 1. CAC>100: Class 1 rec intensive LLT management, LDL target <70 (AGREE) 2. Moderate to severe incidental CAC on non gated , where almost exclusively you will have close to create than >100 on gated: Class II for same LDL goals <70 (DISAGREE WITH CLASS REC) Any thoughts on this?

National recognition for #PittMed research leadership: four University of Pittsburgh School of Medicine faculty members are newly elected to the American Society for Clinical Investigation. bit.ly/4sCOs6D

It’s 🎃 painting time with co-residents @HCAHouston @UHouston 😄

Pal & colleagues identified a conserved role for #PCNA & #POLD1 in regulating pathologic #cardiomyocyte growth & highlights the therapeutic potential of targeting this pathway. Learn more at ahajrnls.org/473Adyn @InnovatorMD @WaldronCJ

Excellent editorial in @CircRes ! Excited to be part of this groundbreaking work led by @S_Pal88 and my mentor Dr. Jason Becker. Congratulations to all the authors. @PittVMI @PittCardiology ahajournals.org/doi/10.1161/CI…

Happy to share our latest research "Targeting Cardiomyocyte PCNA and POLD1 Prevents Pathologic Myocardial Hypertrophy" just published in @CircRes | Thank you Dr. Becker and the entire team who made this possible👏 @PittVMI @PittDeptofMed @HviUpmc ahajournals.org/doi/10.1161/CI…

We used to drive to the airport at night. I was in my twenties—exhausted from med school classes / library and hospital rounds, but still full of hope. The airport was close, and it felt like the edge of the world. We’d sit for hours, watching planes take off, engines roaring into the dark, and I’d think, One day, I’ll be on one of those. I’ll fly away. I’ll make something of all this. One day I took my first flight in life. It was Ahmedabad- London- Philadelphia! All of those nights watching those planes- world was open and waiting for me.. And today, hearing the news—
The crash. Along with all 242 passengers - The unofficial reports of close to 75 medical students- Gone. Their dreams- gone. It’s such a sad day. Each of them had stories. Books they hadn’t finished. Futures they were working for. Maybe they watched planes take off too, thinking the same thing I did. 
This feels so personal.
 So live. Don’t wait. Take the trip. Quit the job. Say what you need to say. Stop postponing joy. Tomorrow isn’t promised.
None of this is.
All we really have is right now and today. #AhmedabadPlaneCrash #BJMedicalCollege #BJites #Medschool

“This is reality; it’s not science fiction. We’re actually doing it. I’ve had patients of mine in the trial receive this one-and-done treatment, and it’s going to change the face of cholesterol management going forward.” sciencefocus.com/news/new-chole…

Life truly comes full circle at #HRS2025—once a patient undergoing life changing ablation, now immersed in learning about it. This incredible branch of cardiology is pure bliss!

“Cardiac Anatomy Expert” stealing the show at #HRS2025, earning its spot as one of the most popular and unforgettable! 🫀

This knowledge is timeless and to our young colleagues/trainees, it is well worth the time invested to learn..these concepts will not change! @HRSonline at HRS 2025 planes 3-D models and Amara Yad displays. @DrRoderickTung

Favorite time of my day - learning all about access from @PeterHannaMD @UCLAHealth #HRS2025

This atlases are a delight to explore. There's truly nothing else that makes understanding the heart so effortless and profound #HRS2025 #AtlasofCardiacAnatomy #AtlasofInterventionalElectrophysiology

It’s a beautiful day at San Diego, my first time attending #HRS2025

@purviparwani Thank you so much, Dr. Parwani, for an excellent session. I hope to cross paths with you at ACC today or later at the Echo lab 🤩

@InnovatorMD Thank you for coming @InnovatorMD! Sorry I couldn’t say hi to you

Dr. Parwani @purviparwani chairing the session “Meet the trialist” #ACC25 Plavix >Aspirin following PCI (SMART CHOICE 3), No benefit limiting fluid intake in HF (FRESH UP), Tricuspid repair reduces HF hospitalizations (TRILUMINATE). Big implications..

Watching Dr. @shivkumarmd discuss advances and clinical trials at #ACC25 is truly a delight. The field is so lucky to him!