insideoutbio

By switching conformation from the two-stranded right-handed Watson and Crick DNA to a four stranded quadruplex structure, many aspects of gene transcription and RNA processing are modulated. doi.org/10.3390/ijms25… #Gquadrupex #flipon #RNA #ZDNA

The "Flipon" book on Z-DNA and Z-RNA and soft-wired genomes is now available on Kindle for free at Amazon. The book is quite eclectic with the history of DNA and many other exciting discoveries described along with the politcs involved.

Why Z-DNA is important in human health. A new paper looking at the role of Z-DNA in bacterial biofilms in systemic lupus erythematosus (SLE) with David Pisetsky @Duke doi.org/10.1136/ard-20…

A picture from the Flipon book on the history of Z-DNA and soft-wired genomes showing the author on the right with Francis Crick on the left and Alex Rich in the middle (taken by Shuguang Zhang). Book now has >5000 downloads routledge.com/9781032731087

In his new book, Dr Alan Herbert, Founder of @insideoutbio, gives an honest account of his journey in the #discovery of left-handed #DNA. DOI: bit.ly/3Wd6bVp Read our article: bit.ly/3JcSXjF

Article featuring #flipons, the biology of Z-DNA and Z-RNA and how #science gets done by the curious and the collaborative #genetics #DNA #RNA researchfeatures.com/dna-flips-way-…

@royalsociety Yes, Parinaz Mehdipour at Oxford has just agreed to be the UK based co-organizer. We will discuss the application tomorrow and plan to submit by April 10th. Thanks for reaching out - we are excited about the roles alternative DNA/RNA conformations play in health and disease.

Could you lead a Royal Society scientific meeting dedicated to your field of research? Proposals are considered twice a year. Submit by 10 April 2024 for consideration in June 2024. See our website to find out more: royalsociety.org/science-events…

The hard copy of the flipon book is also available at routledge.com/9781032731087 (you can use the discount code SMA22)

The open access version of Alan Herbert's book on flipons is now available for download. Learn about dynamic ways of encoding genetic information within the genome and how these findings pave the way for a new generation of RNA therapeutics taylorfrancis.com/books/oa-mono/…

@CrumlyChuck Thanks Chuck - nice to have the work of so many recognized!

Work from one of our authors was just featured in the Royal Society "Chemical World Publication." 🎉Congrats Alan!!🎉 @insideoutbio Alan Herbert President and Founder chemistryworld.com/features/more-…

Altimetric on the Z-DNABERT paper that maps Z-DNA in the human genome to quantitative traits and mendelian disease life-science-alliance.org/content/6/7/e2…

Our paper using the same transformer algorithm in ChatBox (and originally developed at Google) to map Z-DNA in the human genome is now out. We show how variants map to a range of different human traits as well as to mendelian diseases. 10.26508/lsa.202301962 @LSAjournal

An RNA Microcode Underlying Embryonic Development The microcode embedded in small RNAs bootstraps gene expression at early stages of embryonic development by changing DNA conformation of flipons (Z-DNA, G4 Quadruplexes and other non-B-DNA structures) mdpi.com/1422-0067/24/5…

An RNA Microcode Underlying Embryonic Development The microcode embedded in small RNAs bootstraps gene expression at early stages of embryonic development by changing DNA conformation of flipons (Z_DNA, G4 Quadruplexes and other non-B-DNA structures) mdpi.com/1422-0067/24/5…

Nucleosomes as mechanical springs that power flipon transitions to change the readout of genetic information by altering the cellular machines assembled at that locus. onlinelibrary.wiley.com/doi/10.1002/bi…

Great article om Z-DNA and Z-RNA in GEN by Anjali Sarkar genengnews.com/topics/cancer/…

Z-DNA enhances immunotherapy in pre-clinical models of treatment resistant cancers nature.com/articles/s4158…

Z-DNA enhances immunotherapy in pre-clinical models of treatment resistant cancers 10.1038/s41586-022-04753-7

All things Z-RNA and Z-DNA at the ABZ meeting. Program and registration at abz.bio May 25th, 4 hours, virtual, free. Many presentations are just about to be published in peer-reviewed Journals

Epstein–Barr Virus: Silencing the Enemy within - Z-DNA/Z-RNA flipons and mechanisms to suppress EBV-dependent cancers and autoimmunity mdpi.com/1422-0067/23/6…