Isha Khan, PhD

My research, describing how certain dioxin-like compounds regulate human hematopoietic stem cell differentiation, has been published. Relative potency of these compounds differs from TEF values from @WHO, with potential implications for risk assessment. authors.elsevier.com/c/1ku0v,6rGhlD…

our work on the molecular differences between transcription factor isoforms is out now in @MolecularCell! key point: 2/3rds of TF isos differ in important properties like DNA binding & transcriptional activity many are "negative regulators" that are misexpressed in cancer

📢 NIH BioArt Source, a free science and biomedical art resource library, offers an array of high-quality illustrations, vectors, & brushes, free to use & download. See the full catalog of free science and #biomedical illustrations: bioart.niaid.nih.gov #FreeResource

Finally the tides are starting to turn!! Cancer isn’t all about DNA mutations, nor even mRNA levels. We launched SyzOnc to map the proteins underlying deadly cancers that are not DNA-driven. journals.plos.org/plosbiology/ar…

Recently published in the new NAM Journal 👉 New frontiers in anti-cancer drug testing: The need for a relevant In vitro testing model. Read more! spkl.io/6013foKRF

@TrowbridgeLab @scienceadvocacy @ISEHSociety Congratulations, Dr. Trowbridge!

It is an honor to be considered alongside the fantastic @scienceadvocacy for the role of Vice President of ISEH. To all @ISEHSociety members: please make an important contribution to the society by voting. It's easy! Good luck to all of the nominees; we are in great hands!!

Visualizing gene structures in R? gggenes, an extension of ggplot2, simplifies the process of creating clear and informative gene diagrams, making genomic data easier to interpret and share. ✔️ Plot gene arrows to represent gene locations and orientations. ✔️ Visualize genomic features, including transcripts and operons. ✔️ Customize labels, colors, and layouts for clear presentations. Whether you're working on genome annotation, comparative genomics, or molecular biology research, gggenes provides a flexible and user-friendly way to display complex gene structures with clarity. The visualization shown here is taken from the package website: cran.r-project.org/web/packages/g… For a deeper dive into creating impactful visualizations with ggplot2 and its extensions, don’t miss my online course "Data Visualization in R Using ggplot2 & Friends!" Click this link for detailed information: statisticsglobe.com/online-course-… #RStats #Rpackage #DataAnalytics #ggplot2 #datastructure #DataViz

Delighted to share new work from our lab: MultiPerturb-seq 🎛️❌📥📤 Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.

This paper changes everything in the AML field. This is the best model of the most frequent and aggressive acute myeloid leukemia. When we beat this disease, we will look back at this paper as marking the beginning of the end. @bowman_rl @rosslevinemd cell.com/cancer-cell/ab…

My blog post for 2024 SOT. Published late. toxchange.toxicology.org/blogs/d-m-isha…

Learning how to “read” the genome is a basic skill for all biologists. As an introduction, here’s a 🧵 about using the genome browser to make a discovery about how we lost our tails. All you need is your 'thinking eye'! (1/13)

NVIDIA just released FREE online courses in AI. Here are 9 courses you can't afford to miss:

@shikhasharma41 @SOToxicology @patosilveyra Congratulations, Dr Sharma!

It was a great honour to receive “Celebrating Women in Toxicology Award” by WIT speciality section of @SOToxicology Also, it was great working as a postdoc representative at Occupational and Public Health Section (OPHSS) of @SOToxicology this year

My research article on the effect of aryl hydrocarbon receptor on modulation of human hematopoiesis in vitro is now online. Take a peek! ashpublications.org/bloodadvances/…