Jacob Hamacher

I’ve always believed the No.1 application of AI should be to improve human health. That work started with AlphaFold, and now at @IsomorphicLabs with the mission to reimagine drug discovery and one day solve all disease! We are turbocharging that goal with $2.1B in new funding.

Mythos found one (1) vulnerability in curl - an open-source software product with an installed base of 20 billion instances. daniel.haxx.se/blog/2026/05/1…

Paul Graham and Jessica Livingston have been role models for me since I started reading PG:s blog 10 years ago. Had a sunny walk in Stockholm, and it was great to hear them admire Stockholm as potentially becoming the #1 destination for builders in Europe. We also spoke about humans' role in the economy, when machine intelligence is able to do all the boring things. What was very clear is that entrepreneurs seeing opportunities, rallying people for change, and trying new things is one of the activities that has been around for 1000s of years, and will continue to exist. Super proud that my hometown can be a role model in all of this, and to help millions of future founders building on the product we're working very hard on, and true pleasure talking to PG and Jessica!

I am training to be cooler than DHH, baby steps though

Hey. This one is for all you early adopters out there! Like I’m sure many of you do, every morning an agent preps me for my day - calendar, news, last 24hrs of Slack - in a morning briefing. But mine lands in my Spotify library, so I can listen to it on my commute. Same app, same experience, same everywhere. Many of us at Spotify have been living with this for a while and find it really useful. So today we're opening it up to see if you do too? Now, your agent of choice can create a Personal Podcast and save it directly to your Spotify library. It's private. It's yours. And it plays everywhere Spotify plays. The use cases feel obvious once you have it: for example a morning briefing built from your calendar and inbox. A deep dive on your class notes before an exam. A travel itinerary narrated for your flight. We've always believed Spotify should be the home for all your audio. Music, podcasts, audiobooks – so why not also the things you make for yourself? Try it out with OpenClaw, Claude Code, or Codex.  Install the Save to Spotify CLI from GitHub on desktop and follow the directions. Describe the Personal Podcast you want to hear and ask your agent to save it to Spotify. It will show up in Your Library.  Early, rough around some edges, and genuinely exciting. Try it out and let us know what you think? Link in comments 👇

@mpawlo Kan tänka mig att de svettas och kämpar. Lider alltid med mina branschkollegor när sånt här händer.

När jag för en gångs skulle skall agera på marknaden -> Avanza nere? ...eller är det bara jag som är inkompetent som vanligt?

@oscarfogelstrm @timothylindblom @paulg @jesslivingston Here is the best practice guide by @mwseibel: youtube.com/watch?v=lw2X3P…

Emmanuel Macron chante « la bohème » accompagné à la batterie par le premier ministre Nikol pachinyan . Dîner d’état à Erevan. La musique en amitié.

@palace Är du tillbaka på "Twitter"? Jag själv känner att det är här man kan hänga med i AI svängarna

Tydligen kan man inte sprida länkar fritt på twitter utan att gruppen blir nerlusad av fulbottar. Om man vill ”vara med” i vad har du lärt dig i dag gruppen så DMa mig.

Om du bara ska se EN tv-intervju i livet.

If you tried OpenClaw in group chats and got mixed results, you GOTTA try again. I changed how agents talk there, it IS SO GOOD NOW. #visible-replies" target="_blank" rel="nofollow noopener">docs.openclaw.ai/channels/group… And if you used GPT and got subpar performance, switch to codex harness. docs.openclaw.ai/plugins/codex-… Enable both and boom.

View of Stockholm.

Den fria världens konstitutionella ledare.

@OdutolaMoses This thread is diabolical. The typos are self-replicating at this point

A lot of jokes from King Charles tonight. “You recently commented, Mr. President, that if it were not for the United States, European countries would be speaking German. Dare I say that if it wasn't for us, you'd be speaking French”

Just went to visit Legora. Most impressive startup I've been to visit in years. They're going to surpass Harvey in 2027. After that their only potential rivals will be the model companies. And if ever there was a territory you could defend against the model companies, law is it.

We're in Stockholm. You know how there are some places where you think "Nice place to visit, but I wouldn't want to live there"? Stockholm is the kind of place that makes you want to live there.

The financial journalist Mr Gabriel Mellqvist over at Handelsbanken's mediahouse EFN asked a good question on X: what was the dotcom-era equivalent of tokenmaxxing? Easy. We bought servers from Marc Andreessen's Netscape. Truckloads of them. I remember rolling them into Posten AB like we were arming a small nation (I was the young and promising person at Posten Strategic Business Development department, today I am neither!). The pitch was always the same: more boxes, more speed, more future. Nobody stopped to ask what we were actually going to do with all that compute. We just knew we needed it before the other guy got it. Some fifteen years later, when we were building Mr Green, the answer changed costume. Suddenly the smart move was building your own racks, stuffing them with HP blade servers, and feeling vaguely industrial about it. I would say: same religion, new vestments, different names. And here we go again.. Nvidia instead of Intel. Anthropic and OpenAI selling tokens by the bushel instead of Sun selling Solaris boxes. Hyperscalers instead of co-lo facilities. The vocabulary has been thoroughly refreshed - tokenmaxxing, context windows, inference - but squint a little and it is the exact same race. It is not called neural networks anymore, now we have transformers. But it has always been about compute. Who has it, who can buy more of it, who can wring more work out of each unit of it. The bottleneck moves: CPU, then bandwidth, then storage, then GPUs ...and now tokens. But the instinct is unchanged. Be fastest. Worry about the business model later. I'd say that the only real difference is that this time ...the servers talk back!

The earliest DOS source code was found on printer paper in Tim Paterson's garage so we've open sourced it on 86-DOS 1.00’s 45th anniversary! This is next-level software archaeology for study, preservation, and plain ol’ curiosity. Go dig in and learn how it was recovered! #DOS #RetroComputing opensource.microsoft.com/blog/2026/04/2…