The latest work from Sorbonne Université by first author Prof. Pierre F. SABOURET and his team is now featured in RCM!
👉 Explore the full study: imrpress.com/journal/RCM/27…
Article Highlights
💡 Does the clinical benefit of PCSK9 inhibitors truly depend on the drug type, or is it primarily driven by baseline LDL-C and patient risk profile?
💡 Why do trials like ODYSSEY OUTCOMES and FOURIER appear to show different patterns of benefit across LDL-C strata, and what explains these differences in real-world interpretation?
💡 Should alirocumab and evolocumab be considered clinically distinct, or are observed differences mainly a reflection of baseline risk, trial design, and treatment strategy rather than drug-specific biology?
✒️ Authors: Pierre Sabouret @SABOURETCardio (Corresponding author), Domenico Mario Giamundo @jamundus20 , Mamas Mamas @mmamas1973
🏪 Affiliation: Sorbonne University, “Tor Vergata” University @unitorvergata, University Hospitals of North Midlands NHS Trust, Keele University @KeeleUniversity
📖 Don’t miss this citable reference for your future research!
Citation format: Pierre Sabouret, Domenico Mario Giamundo, Mamas Mamas. Focus on Baseline LDL-C and Patient Risk, Not Drug Type: A Perspective on Alirocumab vs Evolocumab. Rev. Cardiovasc. Med. 2026, 27(4), 50430.
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