Jay Lu, DPhil

A quick overview of Optical Mapping System for cardiac electrophysiology research. Effortlessly record cardiac membrane potential and calcium transient. #opticalmapping #cardiotwitter #Cardiology #arrhythmia #heart @MappingLab_EP

@S_HamiltonLab Congratulations 🥂🥂

Thrilled to share the Hamilton lab has received our first Notice of Award for an NIH R01; ‘The roles of endoplasmic reticulum stress in cardiac arrhythmias’. I am so grateful to NHLBI and those who supported us to get here. Stay tuned for postdoc position…

This study shows how mechanistic electrical mapping reveals treatment effects that conventional arrhythmia endpoints alone cannot, helping bridge efficacy with underlying cardiac electrophysiology.

Beyond reducing arrhythmias, can a therapy restore cardiac electrical conduction? MEA electrical mapping provides the answer by directly measuring conduction velocity, activation patterns, and electrical heterogeneity.

Hard to compete with the World Cup tomorrow, but hope you join us! Thank you to @sgpweb @OsamaHarraz and EpIC for the invite!

We are now exhibiting at @ISHR_NAS. Feel free to visit our booth if you re around.

A new study shows that inherited arrhythmias like CPVT are not driven by cardiomyocytes (CM) alone. Using hiPSC-derived neuro-cardiac models, the team found dysfunctional sympathetic neurons can trigger #arrhythmia in otherwise healthy CM. #electrophysiology #cardiology #mapping

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One of the simplest ways to record field potentials and ECG in a Langendorff heart preparation. Simply apply microelectrode arrays and ECG electrodes directly to the heart. #CardioTwitter #Electrophysiology #ElectricalMapping #DrugScreening #Cardiotoxicity #iPSC #Heart

@niels_voigt Great work! 🥂🥂

An adventurous scientific journey through optical pacing of iPSC-CMs, optical mapping, and mouse models of AF reached a major milestone this week: Yannic Döring successfully defended his thesis, “Multicellular models of altered cytosolic calcium buffering in atrial fibrillation,” with magna cum laude. Huge congrats—hard work and perseverance truly paid off! 🎉

Great news! Definitely worth a read. Congratulations! #mapping #electrophysiology #heart #science

The first gene-edited miniature pig model of LQT2 is here. By combining ECG telemetry, electrical mapping, and optical mapping, this study delivers a truly translational view of hERG-related arrhythmias in a large-animal heart. Short version: bit.ly/4jaguCV

Calcium and Contractility Mapping System: An Integrated Solution for Cardiac Research open.substack.com/pub/jayjaylu/p… #Cardiology #cardiomyocytes #ipsc #mapping #calciumimaging #opticalmapping

Yu et al. (2025) showed that an Andr-loaded atrial patch prevents POAF by reducing inflammation, oxidative stress, and calcium imbalance. In a rat model, it lowered Afib incidence from 90% to 20% and protected heart cells, highlighting a promising targeted therapy for POAF.

Unlock the mysteries of cardiac arrhythmias with our advanced Electrical Mapping System! High precision data acquisition and MEA provide unparalleled insights into electrical activity at the tissue level. Perfect for anti-arrhythmic drug screening and toxicity testing.

Our electrical mapping workflow offers a fast and accessible way to measure epicardial field potentials — ideal for quick assessments in drug testing and disease models. ⚡❤️ #activationmap #electrophysiology #Langendorff #drugscreening #cardiotwitter #Cardiology

@jerome_montnach @institut_thorax So excited to see more mappers joining the cardiac electrophysiology field. Well done! 🥂🥂

That’s always a pleasure to train scientist on optical mapping @MappiLab_EP @institut_thorax. Very nice calcium and voltage data from RV #cardioids.

Come to join us for exchanging ideas and networking with colleagues and friends.