Jay

@supplementmaxer Does thiamine do this to you? Since it increased acetyl choline?

even the slightest increase in choline or ach makes me feel like doom, gonna try the parkinson’s anticholinergenics soon to see what happens

@HansAmato Do you recommend cycling it? Or is it something that’s better to take everyday?

Agmatine is one of the most misunderstood molecules in your body. Most people know it as a "pump supplement." That's like grabbing an elephant by the tail and thinking you understand the animal. Agmatine is incredible for pumps, but also: → Blocks pathological glutamate overactivation (less rumination, less anxiety) → Reduces excess nitric oxide in the brain (less panic, less neuroinflammation) → Tones down runaway sympathetic output (calm focus without sedation) → Restores BDNF and lowers cortisol under chronic stress → Improves blood flow where it matters (including erections) → Feeds the polyamine system (mood, plasticity, stress adaptation) → Rises naturally during acute stress — it's your built-in damage control Your body already makes this. It's not a stimulant. It's not a nootropic. It's part of your internal braking system. And most people have never heard of it.

@DelixLabs @HansAmato Nasal?

Underrated take. The glutamate-GABA imbalance is exactly why a lot of guys feel "wired but flat." Selank and Semax actually shift this axis fast, both are heptapeptides that modulate GABA-A and dopaminergic tone without sedation. Pair with proper E2 management and the picture clears up.

If you’ve ever had “too high” libido, this explains it. Manic libido can be driven by oestrogen because it increases glutamate, which is excitatory and pro-libido. The reason it becomes uncontrollable is because there is no extra GABA to help offset it. DHT (and other 5-alpha reduced steroids) on the other hand increases noradrenaline, which is pro-libido, but it also offsets it by enhancing GABA signaling. Which is balanced so you have balanced libido. Too much sympathetic nervous system stimulation makes manic libido; too much GABA stimulation lowers libido. So you want to have a good in-between, which is why something like androsterone is so good for controlled libido.

@HansAmato Me reading this thinking “that’s me”🤣

The confident, sharp, social version of you that disappeared in your late 20s isn't gone. He's trapped behind a wall that nobody tested for You remember him Walked into rooms and talked to anyone. Handled pressure without spiraling. Woke up and felt like doing things. Had ideas and actually executed them. Laughed harder. Thought faster. Didn't need 3 coffees to feel alive or 3 drinks to feel normal Then somewhere around 26, 27, 28, it started slipping. So gradually you didn't notice until it was gone Now you're tired by 2pm. Anxious in situations that never used to bother you. Foggy. Irritable. You've lost the ability to just BE somewhere without overthinking every word. Your motivation runs on caffeine and guilt instead of actual drive You went to your doctor. "That's just getting older." Maybe offered you an SSRI. Maybe said exercise more. Maybe said "stress management" Nobody checked a single thing in your body Here's what actually happened: Years of stress, caffeine on empty stomachs, undereating or eating garbage, and poor sleep destroyed your gut lining. A toxin (endotoxin) started leaking into your bloodstream. Your immune system has been stuck in permanent activation mode ever since That chronic immune activation burns through magnesium. Low magnesium destroys GABA production. GABA is the molecule that keeps your brain calm, your confidence stable, and your nervous system from running hot 24/7. Without it, everything feels like a threat The same inflammation tanked your B12 absorption, which crashed your methylation, which is the system your brain uses to produce and recycle every neurotransmitter responsible for focus, drive, mood, and mental speed Your testosterone didn't drop because of age. It dropped because endotoxin directly suppresses the cells that produce it. And the zinc you need to support it can't absorb through an inflamed gut That sharp, confident, social guy didn't age out. His biochemistry got buried under a cascade of inflammation, nutrient depletion, and hormonal suppression that started in the gut and nobody thought to look there The version of you that shows up after 3 drinks? That's the real you. Alcohol temporarily restores the GABA tone your brain is supposed to produce on its own. The wall between sober you and drunk you is not psychological. It's a measurable neurochemical deficit. And it's fixable I was this guy. Sweating during basic conversations. Couldn't talk to women sober. Built my entire social life around alcohol because it was the only way to access my own personality. Spent years thinking I was just an anxious introvert Fixed my gut. Restored magnesium and zinc. GABA came back online. Sober me became the person drunk me used to be. Same confidence. Same humor. Same ease. No hangover You have no idea how bad you feel until you feel good link in bio if you want to know how

@HansAmato Does this also occur with Magnesium Threonate?

Be careful of magnesium. Yes we all need magnesium, however, if your small intestinal transit time is too fast, you’re already struggling to absorb nutrients properly. Now you’re loading up on magnesium and speeding it up even more, reducing nutrient uptake even more. What a way to quickly worsen nutritional deficiencies.

@HansAmato How do we fix this?

Cold hands. Tight chest. Shallow breathing. That’s not “just anxiety.” Low CO2 → vasoconstriction → reduced oxygen delivery → increased norepinephrine. Your body feels unsafe. So your mind follows.

@HansAmato Thank you Hans for continuing to post useful and valuable health information to better ourselves and tackle problems that a lot of us go through but don’t know how to solve! I’ve learned so much and I can tell my body has benefited from your advice💪🏻

You didn't "lose your edge" in your 30s. Your methylation broke down and nobody told you it was even a thing That sharpness you had at 24 where you could work all day, go out at night, sleep 5 hours, and still think clearly the next morning wasn't youth. It was a body that could process and recycle neurotransmitters efficiently. Dopamine got made. Serotonin got made. They got used and cleared and rebuilt in a loop that ran clean Then your B12 started dropping because your stomach acid declined from years of stress and coffee on an empty stomach. Your folate utilization shifted because you've got an MTHFR variant you've never been tested for. Your homocysteine crept up quietly. Your SAMe production fell off. And now you can't focus. You're irritable for no reason. You have this low-grade brain fog that never fully clears. Caffeine used to sharpen you up and now it just makes you anxious. You forget why you walked into rooms. You used to read for hours and now you can't finish a paragraph You went to your doctor and he said "that's just getting older." Maybe prescribed something for focus or anxiety. Probably didn't test homocysteine. Definitely didn't test methylmalonic acid or run a functional B12 panel You're running a cofactor bottleneck in the one-carbon metabolism cycle that controls how your brain makes, uses, and clears every neurotransmitter you rely on to function. Actually fixing it: Get homocysteine tested. If it's above 8 you have a methylation issue whether you "feel" it or not Active B vitamins (methylfolate + methylcobalamin + P5P). Not the cheap cyanocobalamin garbage in your CVS multivitamin that your body can barely convert Creatine. Handles roughly 40% of your methylation burden and takes pressure off the whole system Eat enough protein. Methionine from animal protein feeds the cycle. Vegans and undereaters run dry here first Glycine and collagen. Glycine is the biggest consumer of methyl groups in the body. Supplementing it directly reduces demand on the cycle Fix the gut (obviously). B12 absorption requires intrinsic factor and adequate stomach acid. If your gut is wrecked, oral B12 barely touches it Your biochemistry is running on empty and every doctor you've seen has mistaken a nutrient bottleneck for time passing. I break down the full methylation pathway, what to test, and exactly how to restore it on my substack. link in bio

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