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r eat

@supplementmaxer

fake peater + research chemical enthusiast

Katılım Ağustos 2025
511 Takip Edilen2K Takipçiler
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r eat
r eat@supplementmaxer·
i think it is very important to emphasise that if you see people talking about any sort of compounds on X that is their experience with it not trying to discredit anything but it is extremely important to do your own independent research even if you aren’t knowledgeable on the topic having some sort of your own knowledge and opinion on something is better than knowing nothing and just simply trusting others on something if you are going to take it, don’t trust me, don’t trust the biggest accounts on X, or even doctors, you must do your best to understand something other people’s experiences are their experiences yours may be different, doubt everyone and everything if someone has a positive experience see that as a possibility for yourself that may occur after you conduct your own research don’t see anything as fact and please when buying anything ensure the source and purity are top condition these aren’t things you should gamble with, some people will put out information that is truly helpful and some people will put out information that is truly harmful it is up to you to decide what to do with the information
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r eat
r eat@supplementmaxer·
@rtnnnie oral gaba? yeah it worked only the first time i tried it after that felt no effect and all it gave me was painful shits
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r eat
r eat@supplementmaxer·
after trying phenibut for the first time i definitely feel like excess excitatory neurotransmission is the root of evil
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r eat
r eat@supplementmaxer·
More than blocking serotonin i find blocking noradrenaline much more enjoyable
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r eat
r eat@supplementmaxer·
@NeoShires safe options for example would be guanfacine (noradrenaline autoreceptor agonist), allopregnanolone, progesterone, proper salt intake, taurine and naicnamide. unsafe / retard options would be like phenibut,baclofen, pregabalin
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r eat
r eat@supplementmaxer·
best healthy alternative but still nowhere near is exogenous estered allopregnenolone, unhealthy alternatives are pregabalin and baclofen, baclofen is nice but i don’t think most people would find it fun and pregabalin fucks up motor control too much and facial edma causing you to look bloated as shit is enough reason for me not to use it often at all
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r eat
r eat@supplementmaxer·
@joosrevil i wouldn’t say nootropic, just extremely extremely extremely anti depressant, i DEFINITELY wouldn’t recommend anybody try it
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Atila
Atila@joosrevil·
@supplementmaxer Thoughts? x.com/aestheticprima…
_aestheticprimal_@aestheticprimal

Some people describe Phenibut acting as a nootropic for them that allows them to get more work done, if that is the case, you have some SERIOUS neuro-inflammation to take care of, like @Grimhood said. It's mainly a GABA-B agonist (can have some Dopaminergic properties in SOME cases) it agonizes all the GABA-B receptors, including the ones that reduce the Glutamergic projections of the mPFC towards Dopaminergic neurons in the Ventral Tegmental Area (VTA), responsible for motivation and eagerness to achieve. In very healthy people, Phenibut should 'sedate' you, and not actually function as a tool to get more work done. The reason that Phenibut likely makes some people productive is mostly because of how it calms Limbic brain regions such as the Amygdala, which reduce anxiety and overall stress. All in all it should be classified as a recreational drug, rather than a nootropic, which makes going out or socializing more fun by reducing social inhibitions.

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r eat
r eat@supplementmaxer·
fuck the locus coeruleus all my homies hate the locus coeruleus
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r eat
r eat@supplementmaxer·
i think phenibut has a lot more to it than what we think it does, baclofen doesn’t exert the same level of tolerance or withdrawal same with pregabalin which covers most of the known effects of phenibut (gaba b and vgccs) of course they have bad withdrawal but nothing as bad as phenibut
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BasedBiohacker
BasedBiohacker@BasedBiohacker·
why is oxycontin prescribed? why is cocaine prescribed? why is desoxyn (METH) prescribed? why is diamorphine (HEROIN) prescribed? why is adderall prescribed... to CHILDREN? why do our doctors hand out percocets like tic tacs? these days medication being prescribed/ FDA approval is not validating anything, but it's a good reason to be really fucking skeptical. don't blindly trust your doctor. if you're curious why, go ask your local junkie how he ended up on the streets...
Peter@Peter9782543801

@Lucky_Libruh @BasedBiohacker If it being a GABA agonist is such a bad thing, then why is baclofen which is a *much more* potent GABA-B prescribed? Just an atom or two from phenibut, as is pregabalin. They can all have the same severe consequences you state if misused, but still have valid use cases.

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r eat
r eat@supplementmaxer·
ask grokers are the most annoying people on the platform
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r eat
r eat@supplementmaxer·
@BerbarianWizard i feel like dht over testosterone if you aren’t looking for muscle and only mental effects, increase in brain e2 above a healthy baseline can be very pro-depressant
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Jamal Dinkoui
Jamal Dinkoui@BerbarianWizard·
Hmm it depends on the cause of depression. If it’s pure hypogonadism then testosterone can help, but I’d probably say allopregnanolone. It restores GABA-A neurosteroid signaling, lowers CRH/cortisol, improves sleep and stress resilience, reduces glutamate excitotoxicity, and supports neurogenesis, things testosterone doesn’t address. It’s especially relevant when 5-alpha-reductase activity is impaired (post-finasteride syndrome, chronic stress, SSRI withdrawal), where progesterone can’t convert to allopregnanolone and the brain loses a key inhibitory neurosteroid. It’s also not theoretical: synthetic allopregnanolone drugs like Brexanolone and Zuranolone are already approved treatments for depression. And the pathway also feeds other neuroactive steroids through the backdoor androgen pathway (androsterone / DHT-related neurosteroids), helping restore the broader neurosteroid environment of the brain, not just androgen levels. Also interestingly, downstream Dihydrotestosterone signaling can increase LH and FSH output, creating a positive feedback loop that may help restore endogenous testosterone production, meaning the pathway can even help when the initial issue is hypogonadism.
AntiDoc@AntiDoc

Testosterone is much safer, much healthier, and considerably more reasonable than any of the other drugs used for treating male depression.

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r eat
r eat@supplementmaxer·
baclofen is one of the most potent wide range anti-stress compounds i’ve ever tried, just need to be careful to not dose often due to dependency risk, i wouldn’t suggest anyone touch gabergenics unless they have extreme self control
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r eat
r eat@supplementmaxer·
@BasedBiohacker i feel like 8mg cyproheptine is much nicer for a long flight knocks you out
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BasedBiohacker
BasedBiohacker@BasedBiohacker·
there is only one appropriate time to consume the devils lettuce and it’s when swallowing a retarded potent edible at the beginning hour of a 12+ hour long redeye flight. knocks you out cold and you’ll only be handicapped for ~1 day after
Morph@doctormorphh

want to know something that reduces connectivity and thus promotes being easily stressed? weed! besides decreasing your IQ, slower thinking and slower mental processing so next time your buddy asks you to smoke you better tell him you're onto better things

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Jamal Dinkoui
Jamal Dinkoui@BerbarianWizard·
Goy’s plan
Sama Hoole@SamaHoole

I haven't used salt in two years. I want to be careful here, because salt is one of those things where the carnivore community has quietly developed a strong collective position that I think deserves examination. Salt is not an animal product. It does not appear in the archaeological record of Palaeolithic diet in any meaningful quantity. It is a mineral additive that humans adopted as a preservation technology, to stop meat rotting, not because the physiology required it. I cut it out two years ago, and the following resolved within weeks: post-workout cramps, fast heartbeat in the evening, low-level anxiety that I'd attributed to other causes, and waking at 2am to use the bathroom. All gone. The mechanism, as I understand it: sodium and water maintain a feedback loop. More sodium requires more water to maintain osmotic balance. More water increases blood volume. Increased blood volume at rest, when you're not actively losing electrolytes through exercise, puts unnecessary load on the cardiovascular system and disrupts the signalling that regulates sleep and urine production. Carnivore resolves so many things. Salt quietly undoes some of them. Worth experimenting with.

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r eat
r eat@supplementmaxer·
meldonium is one of the most energy increasing compounds i’ve ever tried, also extremely thermogenic more than t3 and progesterone i would say, the russians were really cooking with this one.
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r eat
r eat@supplementmaxer·
@el7_77 i don’t think so since it’s mechanism is inhibiting L-carnitine synthesis and forcing glucose oxidation
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El
El@el7_77·
@supplementmaxer Does tolerance happen with long term dosing?
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r eat
r eat@supplementmaxer·
@immer1000 like 200-450mg, definitely not for often use. funnily i get drawn away automatically after a day of use due to edma making my face bloated id rather be sober than on pregabalin but bloated as shit
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Frank
Frank@immer1000·
@supplementmaxer How much do you take? 25mg? 50? I have a friend who has a prescription and I want to try it this week. For social settings because alcohol is so pointless for me nowadays Whats also crazy is that people are on pregabalin indefinitely
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r eat
r eat@supplementmaxer·
pregabalin (i wouldn’t suggest unless you have extreme will power even if you do still don’t take it if you don’t need to) is probably one of my favourite compounds it’s everything alcohol should’ve been, the risk though is actual dependency so i make sure not to take it more than twice a week
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r eat
r eat@supplementmaxer·
@mickybuns i think that’s very funny rather than yucky like a hangover from drinking
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Micky
Micky@mickybuns·
@supplementmaxer not fun waking up the next day and not being able to walk straight
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Keşfet

@rtnnnie @TheFelixArnold @NeoShires @joosrevil @BerbarianWizard @BasedBiohacker @elonmusk @BarackObama