
juan lopez
21.5K posts

juan lopez
@jd1lopez
El mundo de la Cardiologia, insuficiencia cardíaca crónica y trasplante de corazón. Cardiopatías Familiares.













🙌 Our last manuscript is out. 👉“Safety of Very Low LDL-Cholesterol: Ten Common Concerns, Misconceptions, and Evidence-Based Clarifications” 📍Very low LDL-C levels continue to generate debate, fear, and misinformation in clinical practice. 📍In this review, we critically examined 10 of the most frequent concerns related to intensive LDL-C lowering: — Cognitive decline — Hemorrhagic stroke — Cancer — Cataracts — Hormonal dysfunction — Diabetes risk — Muscle symptoms — Older adults — Sex differences — Overall cardiovascular benefit 📍The key message is clear: RCTs, meta-analyses, and genetic evidence consistently support the safety profile of very low achieved LDL-C levels in appropriately selected high-risk patients. 📍Some adverse effects are real — particularly statin-associated dysglycemia and muscle symptoms — but their absolute risk is generally modest compared with the magnitude of ASCVD risk reduction. 📍Therapeutic inertia and misinformation remain major barriers in preventive cardiology. Evidence-based communication matters. 📍Lower LDL-C. Earlier. Longer. Safer than many still believe. ☝️Proud to collaborate with outstanding colleagues from Latin America, Europe, and beyond in this international effort. 🔗 doi.org/10.1016/j.athe… @society_eas @ATHjournal























