Jerry

I’ve always believed the No.1 application of AI should be to improve human health. That work started with AlphaFold, and now at @IsomorphicLabs with the mission to reimagine drug discovery and one day solve all disease! We are turbocharging that goal with $2.1B in new funding.

This is the the quote I've been citing a lot recently.

@szeloof @atomic_semi Welcome!

I’m thankful for 4 years in California . But, the Next Phase is in Texas. We shift our hiring focus to build huge operations in Austin, Texas. Join us ! The team is really great. @atomic_semi New 120,000 square feet HQ for R&D and production:

very cool, similar to claude desktop voice feature but even more helpful

Tradition as Civilizational Memory --- Tradition, at its best, is a form of cultural memory. It binds individuals to a lineage of meaning, stabilizes institutions, and provides the moral architecture within which human action becomes intelligible and rightly ordered. In Ancient Rome, the Mos Maiorum — the “way of the ancestors” — was an unwritten constitution of customs, virtues, and precedents that governed Roman life more powerfully than any legislation. It embodied the accumulated wisdom of the forefathers and prescribed the character expected of every Roman, ordering religion, politics, and social conduct with a gravity no legislation could rival. Fidelity to the Mos Maiorum was understood by plebs and politicians alike as the most effective safeguard against socio-political novelty, moral corruption, and institutional decay.

I often re-read @natfriedman's personal website (former Github CEO)

I built a fun MPP experiment on @tempo_xyz. Pay $0.10 to tweet from my account — price doubles each time. AI moderates so nothing too crazy gets through. Send your agent mpp-kappa.vercel.app/agent.md to get started.

"Thinking is the function. Living is the functionary. " - Emerson

It is hard to communicate how much programming has changed due to AI in the last 2 months: not gradually and over time in the "progress as usual" way, but specifically this last December. There are a number of asterisks but imo coding agents basically didn’t work before December and basically work since - the models have significantly higher quality, long-term coherence and tenacity and they can power through large and long tasks, well past enough that it is extremely disruptive to the default programming workflow. Just to give an example, over the weekend I was building a local video analysis dashboard for the cameras of my home so I wrote: “Here is the local IP and username/password of my DGX Spark. Log in, set up ssh keys, set up vLLM, download and bench Qwen3-VL, set up a server endpoint to inference videos, a basic web ui dashboard, test everything, set it up with systemd, record memory notes for yourself and write up a markdown report for me”. The agent went off for ~30 minutes, ran into multiple issues, researched solutions online, resolved them one by one, wrote the code, tested it, debugged it, set up the services, and came back with the report and it was just done. I didn’t touch anything. All of this could easily have been a weekend project just 3 months ago but today it’s something you kick off and forget about for 30 minutes. As a result, programming is becoming unrecognizable. You’re not typing computer code into an editor like the way things were since computers were invented, that era is over. You're spinning up AI agents, giving them tasks *in English* and managing and reviewing their work in parallel. The biggest prize is in figuring out how you can keep ascending the layers of abstraction to set up long-running orchestrator Claws with all of the right tools, memory and instructions that productively manage multiple parallel Code instances for you. The leverage achievable via top tier "agentic engineering" feels very high right now. It’s not perfect, it needs high-level direction, judgement, taste, oversight, iteration and hints and ideas. It works a lot better in some scenarios than others (e.g. especially for tasks that are well-specified and where you can verify/test functionality). The key is to build intuition to decompose the task just right to hand off the parts that work and help out around the edges. But imo, this is nowhere near "business as usual" time in software.

A teacher’s task is not to ensure that students have read the literary canons. It’s to kindle excitement about reading.

Made a storybook generator (uponatoken.com), now we create & read 4-5 stories every night. Sends stories to Kindle, and cover art to 🖼️. Try it!

Chrome 146 includes an early preview of WebMCP, accessible via a flag, that lets AI agents query and execute services without browsing the web app like a user. Services can be declared through an imperative navigator.modelContext API or declaratively through a form.

@MrinankSharma this is such a beauty. Thanks for sharing this.

Today is my last day at Anthropic. I resigned. Here is the letter I shared with my colleagues, explaining my decision.

Apparently there was a EO L-208, issued in 1942 to effectively shut down the entire American gold mining industry to divert critical machinery and labor toward the production of strategic wartime metals like copper and zinc.

@blauyourmind x.com/Prithvir12/sta…

The transition from prediction markets to options will happen slowly and then suddenly...

Diffraqtion just announced their $4.2M pre-seed round. They're using tech to rebuild the retina; it’s a programmable quantum lens that shapes light before the sensor. ADIN is proud to back the team building vision engineered for inference.

pretty excited updates. anthropic.com/news/healthcar…

Austin if the 1920s Art Deco never ended.