JFC

My usually easy, fun (Danish) crossword puzzle now has an “error” in it, it would seem… #Ukraine #TrumpIsARussianAsset

Exciting postdoc opportunity on long read sequencing of human clinical material, in my group job.jobnet.dk/CV/FindWork/De…

Our new paper "GLP-1-directed NMDA receptor antagonism for obesity treatment" is out today in @Nature nature.com/articles/s4158… We describe the engineering and preclinical development of a new drug candidate that targets NMDA receptors in GLP-1 receptor neurons. 1/8 🧵👇

@cremieuxrecueil After 15y in ‘exercise medicine’ research, I get an instant visceral reaction every time a post says “BREAKING/LOOK: EXERCISE IS MORE EFFECTIVE THAN DRUGS/OTHER TREATMENTS FOR CONDITION X/Y/Z”, because A) it is never actually a comparison, and B) well…this (sigh)

This study should be retracted, both for issues the authors can address and issues with the underlying data. Short thread.

"Leaver: I want an omelette". Utterly brilliant analogy for Brexit today.

‼️ Personalized Biomarker-Based Umbrella Trial for Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: KCSG HN 15-16 TRIUMPH Trial ORRs of literally 0% in NGS matched drugs! What a complete boondoggle this stuff is. Truly sad! ascopubs.org/doi/10.1200/JC…

"The Right wants strict rules on everything. From what teachers can teach, to who can read to children... But when it comes to just f*cking filling out paperwork to get a gun, TOO FAR! But inconvenience is not the same thing as infringement." LEGEND. 🔥

Robert De Niro’s full statement on Trump. Please read and let me know your thoughts: I’ve spent a lot of time studying bad men.  I’ve examined their characteristics, their mannerisms, the utter banality of their cruelty. Yet there’s something different about Donald Trump. When I look at him, I don’t see a bad man. Truly. I see an evil one. Over the years, I’ve met gangsters here and there. This guy tries to be one, but he can’t quite pull it off. There’s such a thing as “honor among thieves.” Yes, even criminals usually have a sense of right and wrong.  Whether they do the right thing or not is a different story — but — they have a moral code, however warped. Donald Trump does not. He’s a wannabe tough guy with no morals or ethics. No sense of right or wrong. No regard for anyone but himself — not the people he was supposed to lead and protect, not the people he does business with, not the people who follow him, blindly and loyally, not even the people who consider themselves his “friends.” He has contempt for all of them. We New Yorkers got to know him over the years that he poisoned the atmosphere and littered our city with monuments to his ego.  We knew first hand that this was someone who should never be considered for leadership.  We tried to warn the world in 2016. The repercussions of his turbulent presidency divided America and rattled New York City beyond imagination.  Remember how we were jolted by crisis in early 2020, as a virus swept the world. We lived with Donald Trump’s bombastic behavior every day on the national stage, and we suffered as we saw our neighbors piling up in body bags. The man who was supposed to protect this country put it in peril, because of his recklessness and impulsiveness. It was like an abusive father ruling the family by fear and violent behavior.  That was the consequence of New York’s warning getting ignored. Next time, we know it will be worse. Make no mistake: the twice-impeached, 4-time indicted Donald Trump is still a fool. But we can’t let our fellow Americans write him off like one. Evil thrives in the shadow of dismissive mockery, which is why we must take the danger of Donald Trump very seriously. So today we issue another warning. From this place where Abraham Lincoln spoke — right here in the beating heart of New York — to the rest of America: This is our last chance. Democracy won’t survive the return of a wannabe dictator. And it won’t overcome evil if we are divided. So what do we do about it?  I know I’m preaching to the choir here.  What we’re doing today is valuable, but we have to take today into tomorrow – take it outside these walls.   We have to reach out to the half of our country who have ignored the hazards of Trump and, for whatever reason, support elevating him back into the White House.  They’re not stupid, and we must not condemn them for making a stupid choice.  Our future doesn’t just depend on us. It depends on them. Let’s reach out to Trump’s followers with respect.  Let’s not talk about “democracy.”  “Democracy” may be our holy grail, but to others it is just a word, a concept, and in their embrace of Trump, they’ve already turned their backs on it.  Let’s talk about right and wrong.  Let’s talk about humanity.  Let’s talk about kindness.  Security for our world.  Safety for our families.  Decency.  Let’s welcome them back.  We won’t get them all, but we can get enough to end the nightmare of Trump, and fulfill the mission of this “Stop Trump Summit.”

Had the distinct pleasure of speaking about all things #prehab at the #congresocofispa2023 last week in beautiful Oviedo. Thank you @cofispa for the invitation, your great hospitality, and some inspired discussions

@HeWaHippo @DrMarkRoss @SamOrange01 @derekamann1 @J__Leslie Some may say, it's a ... conumdrum? 😉

@DrMarkRoss @SamOrange01 @derekamann1 @J__Leslie Great lead by @SamOrange01! Thanks for involving team Munich!

New article- The exercise IL-6 enigma in cancer. Led by @SamOrange01, and pleasure to work with @derekamann1 , @J__Leslie and @HeWaHippo. Learned lots from contributing to this

Hjalte Froholdt is READY for his first chance to be a full-time starter at center this season in Arizona. Whew

🔁 RT if you think 🇩🇰 @Mads__Pedersen is the Super-combative of the #TDF2023! 🔁 RT si vous pensez que 🇩🇰 @Mads__Pedersen est le Super-combatif du #TDF2023 !

@HenryG_Smith Fingers crossed Henry 🤞it’s a great grant and both timely and important studies lined up!

Harms of exercise training in patients with #cancer undergoing systemic treatment There is currently insufficient data on harms to make evidence-based risk-benefits assessments of the application of structured exercise in this population bit.ly/43v1Pdb

A landmark trial demonstrating significant improvement in survival in #breastcancer by our Director, Dr Rajendra Badwe. Simple (and inexpensive) injection of local anesthetic prior to breast cancer surgery saves lives. ascopubs.org/doi/abs/10.120…

Hands down: funniest one of the day 😂😂😂

Observational - to be confirmed – we hypothesize that elevated pre-chemotherapy inflammation causes ´immune cell exhaustion´; given elevated/chronic exposure to TNFa linked to Tcell dysfunction, and IL-8 may impair NKcell function. Great Nordic collab with the PhysCan group! 2/2

Final PhD paper from the ever so industrious Tim Schauer is out. Pre-treatment systemic inflammation by IL-8 and TNFa was independently associated with risk of chemotherapy dose-reduction in patients with breast cancer. 1/2

@BoSchwartz MEGET enig - også i andre settings. Fx de prediktionsmodeller, der returnerer "realtime winning percentages" i (betting-tunge) sportsgrene kunne også vel også, ala dette, deklarere at fx 65%-35% (vel?) reelt er sum-probability af MANGE(alle) mere eller mindre sandsynlige udfald?

“Det er kun en prognose. Vi kan ikke være sikre endnu.” blev sagt flere gange i løbet aftenen. Men det var det samme som blev sagt i starten og i slutningen. Og prognosen er vel forhåbentlig blevet mere præcis i løbet af aftenen.

Grafen er opfundne tal. Jeg tror at det ville blive et bedre produkt hvis DR/TV2 viste usikkerheden på deres prognoser i løbet af aftenen. Ellers får man det indtryk at den er lige så sikker i starten som til sidst. Og de interviewer folk på den baggrund. Men det er ikke sådan.