Jan-Hannes Schäfer

@AlanRoseman3 We have the solution. Thanks!

@jhschaef It's collagen VI

@RuetterM Thanks. You are right, they look very similar. We might have solved it. I'll keep you updated. Let's see what ModelAngelo thinks... If there is high resolution.

@jhschaef Looks super cool! Looks similar to the Dynein classes, see Figure S1C here: sciencedirect.com/science/articl… what do you think?

Our Structure of the yeast Ceramide Synthase is now out @NatureSMB! Thanks to all involved from @FlorianFrhlich3 and @MoellerGroup. rdcu.be/dZRn9 #cryoEM #uos

Happy to see another chapter of my PhD work on yeast SPT-Orm2 out at @CellReports. Thanks to all involved! doi.org/10.1016/j.celr… #lipidtime #cryoEM

@sonjawelsch @MoellerGroup @DJanuliene @UniOsnabrueck @seegerlab @FlorianFrhlich3 Thanks @sonjawelsch

@jhschaef @MoellerGroup @DJanuliene @UniOsnabrueck @seegerlab @FlorianFrhlich3 congratulations @jhschaef and the (indeed fantastic) @MoellerGroup!

Happy to have contributed to solving Gaucher's disease GCase-LIMP-2 complex. Congrats to first Jan Philipp Dobert from Zunke-lab & Arnold-lab and all others. @MoellerGroup @Molecular_Neuro researchsquare.com/article/rs-433… #b3d #cryoEM

Our #lipidtime story continues with yeast SPT-Orm2! Great team-work with co-first Carolin Körner from @FlorianFrhlich3. @MoellerGroup @DJanuliene @krparey and @teislab Oliver Schmidt. #b3d #cryoEM Have a look doi.org/10.1101/2024.0…

@sonjawelsch @MoellerGroup Next time for shure. 😂

@jhschaef @MoellerGroup did the boss chicken out, or take the photo?

Update: Congrats to @DavidBSauer and team for solving human CerS6 doi.org/10.1101/2023.1… - Who knew, its a "ping-pong" mechanism!

Preprint Alert! 📣We've solved the first structure of a Ceramide Synthase. Great Team work @FlorianFrhlich3 @MoellerGroup @DJanuliene @UniOsnabrueck Thanks to co-first Lena Clausmeyer & Carolin Körner! #uos #cryoEM #openscience doi.org/10.1101/2023.1…

Update: Nice work from Xin Gong on homo-dimer of yeast CerS on EMBO doi.org/10.15252/embj.…

@DavidBSauer @TomasPascoa @CmdOxford @Boehringer @BoehringerDE @UZH_en @DavidBSauer Would you be willing to add the Supplementary Material to bioRxiv too? Allways curious to see the full processing workflow.

@DavidBSauer @TomasPascoa @CmdOxford @Boehringer @BoehringerDE @UZH_en @DavidBSauer Congrats to all involved! This aligns with our findings from yeast Ceramide Synthase doi.org/10.1101/2023.1…

Ceramide Synthase 6 (CerS6) uses a ping-pong reaction mechanism! Found and probed via CryoEM, MD, and MS. Spectacular work by @TomasPascoa and colleagues from @CmdOxford, @Boehringer (@BoehringerDE), and @UZH_en biorxiv.org/cgi/content/sh…

@vicsnorr @IevaDrulyte @FlorianFrhlich3 @MoellerGroup @DJanuliene @UniOsnabrueck Thanks Victor. Highly recommend Blender and #MolecularNodes from @bradyajohnston

@jhschaef @IevaDrulyte @FlorianFrhlich3 @MoellerGroup @DJanuliene @UniOsnabrueck Congrats Jan-Hannes! Beautiful renders too 😍

@vicsnorr @_Murphy_Lab Congratulations 🎉 Very nice story!

Thrilled to share the first results from my PhD @_Murphy_Lab! We were able to resolve a 46-kDa membrane protein to 2.2 Å without fiducials and with multiple substrates bound! Also a mutant structure gives insight into the process of the hydride transfer for the NOX proteins.

@alebarbieri87 @MoellerGroup @NatureComms @FlorianFrhlich3 I've used Blender with Molecular Nodes from @bradyajohnston

@jhschaef @MoellerGroup @NatureComms @FlorianFrhlich3 Hello. Which program has been used for generating this picture?

Our paper on "Structure of the ceramide-bound SPOTS complex" is now out in @NatureComms - Fantastic teamwork with co-first Carolin Körner from @FlorianFrhlich3 nature.com/articles/s4146… @MoellerGroup #CryoEM #UOS 🔬❄️

@sonjawelsch @DJanuliene @NatureComms @FlorianFrhlich3 @MoellerGroup Thanks @sonjawelsch - Revisiting seemingly bad 3D classes got us there. @DJanuliene was of great help all the way - a great mentor. CryoEM is always teamwork. Thanks @krparey for the #magic during model building!

@jhschaef @DJanuliene @NatureComms @FlorianFrhlich3 @MoellerGroup A three-in-one #cryoEM sample, and all maps at nearly the same resolution - well done @jhschaef and colleagues! Another good day for #proudpi I guess.

The yeast SPOTS complex involves Sac1 🟣 and is bound to ceramide and ergosterol. Let's find out more about this cross-talk between the membrane code and protein activity.

@klausenhauser @MoellerGroup Thanks to @YongChan_zzz - have a look at his 🧵

@jhschaef @MoellerGroup Oh I see Coot in ChimeraX style

That is a first for me on our Glacios. No ApoF. Friday #cryoEM goals unlocked 🍩 #uos @MoellerGroup