jlenia Monfregola

Don’t try this at home, but Colossal Chief Science Officer, Dr. Beth Shapiro, breaks down the extremely complex process of making a dire wolf into a simple seven steps you’ll actually understand.

The 2024 #NobelPrize laureates in chemistry Demis Hassabis and John Jumper have successfully utilised artificial intelligence to predict the structure of almost all known proteins. In 2020, Hassabis and Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic. Read more about their story: bit.ly/3XI7KK3

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

Paul Gissen is a great speaker and a wonderful advocate for rare disease. Lovely to hear him chatting away with @brunetti_pierri and @JBaruteau37171 in this episode on Liver Directed Gene Therapy.

Congratulations to Sara for publication of her new paper🥳👏 We investigated effects of the lysosome enrichment approaches SPIONs and TMEM192 overexpression on the lysosomal proteome and combined both to achieve highly pure lysosomes. Check it out : pubs.acs.org/doi/10.1021/ac…

There is still time for abstract submission! Please, share! 😊

Having a great time at our FOR2625 symposium in Berlin with great science of our FOR2625 members and amazing external speakers from around the world 👌😀

#Echobox=1714468384-1" target="_blank" rel="nofollow noopener">nature.com/articles/d4158…

👏👏👏👏👏👏👏👏👏👏👏👏👏

DNA damage and transcription stress dlvr.it/T10QkW

still one of the top christmas gifts i have ever received 🧬

#AlphaMissense, a tool by @GoogleDeepMind, can help researchers learn more about the effects that missense mutations have on disease, and could help identify previously unknown disease-causing genes, according to a Science study. Learn more: scim.ag/5iY

⏰WE ARE HIRING 3+y postdoctoral positions in the context of a major @AIRC_it grant 🎉 we will pursue our studies on mitochondrial mechanotransduction in breast cancer metastasis, including new mouse models & new drugs in the pipeline Please RT and DM if you are interested

CRISPR 2.0: a new wave of gene editors heads for clinical trials go.nature.com/41cl5vk

In two independent Science studies, researchers used time-resolved crystallography at an x-ray free electron laser to capture the process of #DNA repair from picoseconds to microseconds. Learn more ⬇️ 📄: scim.ag/57W 📄: scim.ag/57V

An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predictions or parts of predicted structures do not agree with experimental data. @TerwillTom nature.com/articles/s4159…

Thrilled to announce our latest exploration of CRISPR! By developing an advanced algorithm, we’ve analyzed 8 terabases of microbial data, leading to the discovery of over 200 novel CRISPR systems. Kudos to @altaetran and @soumya_kannan12 for their exceptional work! Details in the thread below:

🎉 A great result by the collaboration among Ballabio’s and @G__Napolitano's group and the two first co-authors @nunzia_p and Adrien Pasquier revealed the key role of #TFEB and #TFE3 in controlling the #GlucoseHomeostasis! More here: embopress.org/doi/full/10.15… #TigemPapers

AlphaMissense, a tool by DeepMind, can help researchers learn more about the effects that missense mutations have on disease, and could help identify previously unknown disease-causing genes, according to a new Science study. Learn more: scim.ag/49l