Jo Langham

In Labour’s perverse world, ‘wealthy’ means up to your overdraft limit and struggling to get by, but not eligible for state handouts.

One of the strangest paradoxes in hormone physiology: a woman can be estrogen deficient and estrogen dominant at the same time. Two camps dominate estrogen conversation and both miss the point. One says supplement estrogen. Bones need it. Skin need it. Brain needs it. The other says estrogen is basically a cellular poison. Promotes proliferation, suppresses thyroid, drives inflammation. Only progesterone matters. Avoid estrogen at all costs. Neither is looking at the full picture. Your body doesn't make a poison. It makes a hormone that requires specific metabolic conditions to be handled safely. Women with truly low estrogen don't ovulate properly, lose bone, lose skin collagen, get vaginal atrophy, recurrent UTIs, joint pain. Even men need it! Men who can't convert testosterone to estrogen develop osteoporosis in their 20s, insulin resistance, and their bones never stop growing. Deficiency is a real problem with real consequences. But so is dominance. And a woman can have both at the same time. Estrogen dominance was never about high estrogen really. It's a ratio problem. If progesterone crashed harder than estrogen did, you're dominant regardless of the number on your lab panel. And if your body can't clear the estrogen it makes, it recirculates and accumulates even when production is low. Three systems clear estrogen independently: 1. Liver conjugation packages it for removal 2. Bile flow transports it to the gut 3. Your gut bacteria (the estrobolome) decide whether estrogen gets excreted or recycled back into your bloodstream And hypothyroidism breaks all three at once. Slows the liver. Thickens bile. Slows gut transit. And suppresses progesterone production on top of it. This is how you get a woman with low estrogen on labs who still has breast tenderness, bloating, and heavy periods. She's deficient in production and dominant in tissue effect simultaneously. Treating only one side makes the other worse. In the full article (link in comments section) I break down the physiology of estrogen behavior and metabolism, the three estrogen clearance chokepoints, the delivery problem (oral equine estrogens vs transdermal bioidentical estradiol), and what testing actually tells you something useful.

Rosenior isn’t the guy. Thats clear to anyone. But if we aren’t bringing in someone who’s won one of the big 5 domestic leagues or the CL, then there really is no point sacking him I’m afraid. Replacing shit with shit doesn’t change anything. People need to understand that.