JS

@OTCSteve42 @kshaughnessy2 @HollensbeAmanda @tctcedu @ClemsonUniv @ClemsonTigers @ClemsonAlumni @HBO @Showtime @netflix Would love to see her work

@js4k13 @kshaughnessy2 @HollensbeAmanda @tctcedu @ClemsonUniv @ClemsonTigers @ClemsonAlumni @HBO @Showtime @netflix I'll let you know when the next one is. She has a few more this year including a true life story.

One of the things we are working on right now for Clemson Bridge is Braelyn’s placement testing — reading, writing, and math. I knew this would be hard for her. Over the last few months alone, she has endured two brain surgeries and is currently undergoing radiation. Her brain is healing, inflamed, exhausted, and trying to recover while still being asked to do very normal “18-year-old” things. So for the last couple of weeks, I’ve been gently preparing her: “Don’t get discouraged. We’ll figure it out together.” Yesterday, we started with math. Basic arithmetic. Story problems. Multiplying and dividing fractions. Honestly, I had to dust the cobwebs off my own brain too. 😂 I made her a times table to refer to, and we worked through the problems side by side. And as we worked, I could see little sparks starting to ignite again. I knew we weren’t starting from ground zero. I knew she had mastered these skills once before. This morning, she opened a reading/writing practice test on her own while I watched quietly from a distance. And then she started crying. I expected it. There were paragraphs to read, grammar corrections, sentence restructuring, organization questions — so many words to process all at once. I immediately told her: “I know, Honey. I get it. That’s a lot right now. But you WILL get there. You’ve done it before and you will do it again. In the meantime, we will do this together.” So I read the passages aloud while she followed along, and we worked through the questions together. A little later, during the time she normally takes a nap after radiation, I noticed she had quietly opened the practice tests again on her own. That moment hit me hard. Because this is what resilience really looks like sometimes. Not big speeches. Not dramatic victories. Just a tired teenage girl whose brain has been through unimaginable trauma… choosing to keep trying anyway. She knows her brain is slower right now. That frustrates her deeply because before all of this, she was incredibly sharp and quick-witted. But those pieces of her are still there. And I believe with everything in me that they are finding their way back. 💜 #DCvaxForBraelyn #Resilience #BrainCancer

@HollensbeAmanda @kshaughnessy2 @tctcedu @ClemsonUniv @ClemsonTigers @ClemsonAlumni @HBO @Showtime @netflix @ABC @NBCNews @lifetimetv @BravoTV I hope @MHRAgovuk is exposed for its inability to fast track $NWBO's live saving cancer treatment for all solid tumors.

@HollensbeAmanda @kshaughnessy2 @tctcedu @ClemsonUniv @ClemsonTigers @ClemsonAlumni @HBO @Showtime @netflix @ABC @NBCNews @lifetimetv @BravoTV Here is an example of the no viable treatment for glioblastoma & senseless deaths. $NWBO's extended wait for approval it's costing lives. A Compassionate case is someone only chance.

$NWBO #DCVax their paradigm changing dendritic cell cancer platform for all operable and inoperable solid tumor cancers will start to become a household name after regulatory approvals hit the markets!

@kshaughnessy2 @HollensbeAmanda @tctcedu @ClemsonUniv @ClemsonTigers @ClemsonAlumni The movie is writing itself. Breakthrough $NWBO glioblastoma, brain cancer therapy & a teenager breaking odds with her fight to go to college. @HBO @Showtime @netflix My subscriptions are paid up. I'm waiting to watch #BraelynsDCVaxStory

$NWBO Most inspiring student. Tri County Tech & Clemson should feature Braelyn’s story/ her fight against brain cancer while doing college level academics. Braelyn’s mom @HollensbeAmanda is documenting the battle @tctcedu @ClemsonUniv @ClemsonTigers @ClemsonAlumni @ClemsonTigerNet @BarstoolClemson @wyffnews4 @WSPA7 @foxcarolinanews @WLOS_13 @CUTigervision @GreenvilleNews @independentmail @GoUpstate @postandcourier) @thetigerCU @UpstateTodaySC @bnimmons59

$MRNA cancer vaccine just terminated in skin cancer. The trial enrolled 46 of a planned 412 patients, ended for “business reasons” with no efficacy data released. Here is why it failed, and why it was always going to fail in this population. The $MRNA approach (developed in partnership with $MRK, whose #Keytruda formed the checkpoint inhibitor arm of the terminated trial) sequences the patient’s tumor, identifies the unique mutations on the cancer cells, and packages those mutations into an #mRNA vaccine. When the patient gets the shot, the mRNA enters their own dendritic cells (the immune system’s teachers), which then translate the mRNA, display the tumor markers on their surface, and instruct T cells to find and kill cells carrying those markers. The mRNA is the lesson plan. The patient’s own dendritic cells are the teachers. The problem is the teachers. Most cancer patients are over sixty, and by that age the body’s teaching cells have largely gone quiet. Decades of inflammation have silenced the master gene (IRF8) that defines a functional teacher cell. A paper from Pittsburgh published this month showed that even in laboratory-prepared dendritic cells, only one in fifty to one in a hundred is actually capable of giving the immune system the right instruction. In the body of a person over sixty, the working fraction is even smaller. $MRNA delivered a perfect lesson plan to a classroom of teachers who can no longer teach. The students (CD4 helper and CD8 cytotoxic T cells) hear the lesson but get the wrong message, becoming tolerant or unresponsive instead of cytotoxic. There is a second problem the $MRNA approach cannot solve. Tumors mutate quickly. The first wave of T cells kills the cancer cells displaying the targeted markers. The cells that survive are the ones that learned to hide those markers. Within weeks, the tumor escapes. This is the escape variant problem that has limited every targeted cancer therapy from CAR-T forward. Two weeks before $MRNA termination, Dr. Pawel Kalinski at the University of Pittsburgh gave a public lecture explaining exactly why this approach would fail and what the solution looks like. His platform manufactures the teacher cells outside the body, in a clean environment where the silencing has not occurred, then sorts for the rare productive subset that actually produces the instructional signal at full strength. The CD4 and CD8 T cells these manufactured teachers educate recognize cancer cells through two mechanisms instead of one: the specific tumor marker AND a stress signal (NKG2D recognizing MIC-A) that cancer cells cannot easily hide from both recognition systems at once. Escape variants get caught by the second recognition system. In his clinical work, this approach produced complete or near-complete responses in seven of nine breast cancer patients in a recent trial. $NWBO owns this platform. Their #DCVax dendritic cell vaccine is built on Kalinski’s technology, manufactured under license from Pittsburgh and Roswell Park. The forward extension Kalinski’s lab is now developing pairs the manufactured teacher with the patient’s own T cells in a closed bioreactor where the teaching signal is delivered correctly, then potentially infuses both the teacher and the educated students back into the patient. The teacher would establish a permanent immune outpost at the injection site. The students would travel through the body and find cancer cells through the dual-recognition system that no current cancer therapy uses. $MRNA model: deliver the lesson plan, hope the teachers can still teach. $NWBO model: build the teacher, deliver the working teacher with the lesson plan already inside, let the working teacher do the instructing. When the teachers in the patient’s body have gone quiet, only one of these models works. Two weeks ago Kalinski explained why. This week $MRNA confirmed it.

$NWBO IFYKYK. If you don't, you might want to learn! Either way this $NWBO train is going to leave the station. You might as well ride.

$NWBO the potential is far reaching and could change the alzheimer outlook along with so many other diseases.

A day at the races, $NWBO 😄

May is brain cancer awareness month. $NWBO DCVax is on the verge of approval -treatment for glioblastoma the deadliest form of brain cancer. It would be so fitting to have approval come in this month. @MHRAgovuk

@Ze1ooooo Chew on this for a while. It could pay off $NWBO

Lunch

@ElvirPons Exciting times! Congratulations to both of you. 🙌👏

Congratulations to my son Dr Michael Pons on his graduation from Rice University. Hooded by his mentor and academic advisor Timothy Morton. So proud and grateful! 👨‍🎓🦉 #RiceGrads2026

@smith348572 @TigonTalker @braintumourrsch @MHRAgovuk We could've gotten this run around in the U.S. if we wanted a major delay in approval of $NWBO @MHRAgovUK 🙃🤦🏻‍♀️

$NWBO @MHRAgovuk and UK is a total disaster. Terrible. How come #DCVAX cell therapy is not already approved? Is someone pressuring or influencing people at @MHRAgovuk not to approve this? It has been 2.5 years since the application was submitted for approval. For a potential breakthrough cell therapy with an exceptional safety profile, the lack of transparency and leadership is becoming impossible to ignore. Maybe @Nigel_Farage should start asking why UK patients still don’t have access to this treatment. Btw, considering where the UK stands on cancer innovation and breakthrough therapies, delaying access to potentially life-extending treatments would be difficult to justify — especially for patients facing diseases with such devastating survival rates. Applicable to all solid tumors. @Siobhain_Mc @Keir_Starmer @wesstreeting @zubirahmed

As Dying Matters Awareness Week comes to a close, it’s a reminder of the importance of open conversations about death, grief and remembrance. 💛 Talking about death isn’t easy, but it can help us remember, share and celebrate the lives of the people we love. After Richard passed away from a brain tumour, his tribute page became a special place for family and friends to come together and keep his memory alive. Every day, 35 people in the UK are diagnosed with a brain tumour. Supporting in memory helps fund the vital research needed to change this. Read Richard's story: bit.ly/4d6MDbX #TogetherWeWillFindACure #DyingMattersAwarenessWeek #BrainTumourAwareness

Northwest Biotherapeutics: $NWBO My top pick into end of 2026. Super high risk (8/10) but potential for multi-bagger.

NWBO Spoofing Lawsuit - A Curious Defense Attorney Addition $NWBO The Case: Northwest Biotherapeutics, Inc v. Canaccord Genuity LLC, 1:22-cv-10185, (S.D.N.Y.) In today's filing attorney Rushmi Bhaskaran entered her appearance for Defendant G1 Execution Services LLC in $NWBO's civil spoofing lawsuit. It's interesting that G1 would bring in someone with experience on the criminal side while $NWBO's case is in civil courts. It makes you wonder what has been uncovered in discovery where Defendants felt the need to bring in this attorney at this particular stage of litigation. "Former Assistant U.S. Attorney for the Southern District of New York Rushmi Bhaskaran—who has more than 15 years of experience handling sophisticated white collar fraud and cybercrime matters—has joined Ballard Spahr’s Litigation Department and White Collar Defense and Investigations Group as partner, firm Chair Peter Michaud announced today. Rushmi is resident in the firm’s New York office." ballardspahr.com/insights/news/… "Former Southern District of New York Assistant U.S. Attorney Rushmi Bhaskaran has joined Ballard Spahr’s Litigation Department, White Collar Defense and Investigations Group, and New York office. Rushmi has investigated and prosecuted white collar criminal cases involving bank fraud, mail and wire fraud, health care fraud, securities fraud, criminal tax violations, computer crimes, money laundering, false statements, sanctions violations, and violations of the Bank Secrecy Act." bizjournals.com/newyork/potmse…

$BELR. I'm just along for the ride. Jumped in a while back at .0008/9. Volume kicking in.

@ChappaquidTeddy @PeteButtigieg @ChedrickGreene Still not willing to look in the mirror. No I'm not a guy and you were trying to do the whole gay thing between me and Pete. Go away little boy.

@js4k13 @PeteButtigieg @ChedrickGreene Read your profile? I think you have main character syndrome. Mind your own fucking business.

I saw firsthand while campaigning with @ChedrickGreene what a committed leader and excellent public servant he is. Congratulations on your victory tonight - I know you’ll continue serving fellow Michiganders well in the State Senate.

@ChappaquidTeddy @PeteButtigieg @ChedrickGreene Read my profile. He sounds really immature and kind of on the dumb side

@js4k13 @PeteButtigieg @ChedrickGreene Hey Pete! I bet @js4k13 will….