John Shearin

I worked at Epic Systems (medical records not fortnite) and every employee had their own private office. On days where we had no team meetings, I would be so depressed when I got home because I'd been trapped in a windowless box all day. Distraction free? Yes. But what is the cost of that.

Let’s be real if you put every engineer into a private office no one would ever talk to each other again. Communication would be 1/100th of what it is in an open plan office.

Sharpie deserves the publicity. It invested in robots and workforce training that led to average wage increases of 50% with no headcount reduction, while also increasing production speed by 3-4x, boosting quality, and not raising prices. wsj.com/business/sharp…

If I think you are an LLM or used an LLM to reply to a tweet I will block you. Aka if you are sycophantic or use lots of emojis unecessarily.

Capitalism creates prosperity

I can't.

We live in the absolute best time to be a knowledge worker. We used to get burned out because we had to do mind-numbing, time consuming tasks. Now we can offload those tasks to LLMs and focus on the creative, orchestration side. 2022 vs 2026

@TheChiefNerd @grok how did Sam Harris get famous? Also is this clip from a podcast?

🚨 SAM HARRIS: “The independent media space has been an engine of conspiracies. Look at Joe Rogan's podcast alone … Then you add to that the truly crazy permutations that come from people like Tucker Carlson and Candace Owens.”

met an endocrinologist at a conference last year who told me something that changed how i think about men's health he said "i see 15 patients a day. twelve of them are men under 40 with the hormonal profile of their grandfathers. and i'm not allowed to tell them that because the reference range says they're normal" "not allowed?" turns out if he diagnoses a 32 year old man with hypogonadism based on a total testosterone of 350 (which would have been flagged as clinically low 20 years ago) his hospital system pushes back. the reference range got updated. 350 is "within range." insurance won't cover treatment. his department head tells him to move on. the patient goes home with "you're fine" ringing in his ears and a body that's falling apart this man has been practicing endocrinology for 22 years. he told me the average testosterone level in his male patients under 40 has dropped measurably in every single year of his practice. not stabilized. not fluctuated. dropped. consistently. every year. for over two decades. and every few years, some committee adjusts the laboratory reference ranges downward to accommodate the new population average. so the decline becomes invisible. you can't be diagnosed with something when the definition of "abnormal" keeps moving to include you he said the most frustrating moment in his career was watching a 28 year old with testosterone at 280, estradiol at 48, zero morning erections, brain fog so severe he couldn't work, and depression that landed him in the ER twice -- get denied treatment coverage because the lab flagged him as "low-normal" "low-normal." 280 ng/dL at 28 years old. that would have triggered an immediate workup and probable treatment in 2005. in 2025 it gets you a follow-up appointment in 90 days what does he tell patients who fall in this gap? "i tell them to order their own labs, find a practitioner who reads the numbers in context instead of comparing them to a reference range built on a sick population, and never accept 'normal' as an answer when their body is clearly telling them something is wrong" "btw i go to my next patient and do it all over again because the system i work inside wasn't designed to optimize health. it was designed to manage disease. and if you're not diseased enough to meet the threshold, you don't exist to the system" this is the guy who went to medical school for 12 years, completed a fellowship in endocrinology, and his professional opinion gets overruled by a lab reference range updated by a committee he's never met your doctor might agree with everything i post. he might know your testosterone is too low for your age. he might know your thyroid isn't functioning optimally. he might know that your "anxiety" is probably metabolic. and he might not be able to do a single thing about it inside the system he works in you are not his only patient. you are his 13-minute slot between two other patients who also got told they're fine stop outsourcing your health to a system that gets paid whether you feel better or not order your own labs. learn to read them. find someone who treats the person, not the reference range

Everyone calls AI output “slop,” but I would be surprised if the median line code written by AI today weren’t higher quality than the median line of code written 10 years ago

Be careful what tools you trust. A repo with 40k stars and 6.7k forks had obfuscated code that sends ALL of the secrets on your machine to a remote server.

Dr. Andrew Huberman just confirmed a “wild conspiracy theory” about incandescent lights and LED bulbs. The long wavelengths found in incandescents increase your metabolism and “charge your mitochondria.” Conversely, the LED bulbs that most of you have in your house are “causing disruptions in mitochondrial function.” DR. ANDREW HUBERMAN: “Your mitochondria function better, you increase ATP production, your metabolism increases in the presence of red light, long wavelength light to the skin.” “Shine long wavelength light on somebody, watch blood glucose levels in a blood glucose test, and it’s blunted.” “Now, the LED lights that are commonly used now… that short wavelength light, in the absence of long wavelength light, has been shown to damage the mitochondria.” “This used to be considered crazy. This was like chemtrail crazy, right?” “But now we’re starting to see from animal studies and human studies, from Glenn Jeffreys and others, that people’s vision gets better when they get in front of an incandescent bulb once a day.” “If they get sunlight, which also has long-wavelength light, your vision improves because of improvements in mitochondria.” The Biden administration quietly pushed incandescents out of the market through aggressive energy regulations. But you can still find them online today if you look hard enough. If that health insight stood out to you, there’s a lot more where that came from. (See post below) This page finds the moments they don’t want going viral, with captions that tell you exactly why they matter before you even hit play. See why 2 million already follow: @VigilantFox

@DeeperThrill I created this skill and have been having really good success generating plans. github.com/jshearin01/age…

My coding workflow is currently: 1. Spend about ten minutes writing a plan for a new feature in a markdown file as bullet points. 2. Spend about an hour with a bunch of back forths between Opus 4.6 and Codex 5.4 xhigh, asking each one to improve the markdown plan file. 3. Read the final markdown plan, which ends up as a bunch of bullet points, includes implementation details, and is usually between 200-500 lines long. 4. Ask either Claude Code or Codex to implement it. 5. Ask the other one to review the implementation. 6. Run my /deslop command on the implementation (see my pinned tweet). 7. Deploy, test, and ask an agent to fix any bugs.

It's almost like competition exists in capitalism.

@fancylancer3991 @NousResearch Could have just used DeepWiki: deepwiki.com/NousResearch/h…

The self-improving memory of Hermes agent from @NousResearch is a pretty neat thing. So I visualized how it works: (1/7)

You didn't "lose your edge" in your 30s. Your methylation broke down and nobody told you it was even a thing That sharpness you had at 24 where you could work all day, go out at night, sleep 5 hours, and still think clearly the next morning wasn't youth. It was a body that could process and recycle neurotransmitters efficiently. Dopamine got made. Serotonin got made. They got used and cleared and rebuilt in a loop that ran clean Then your B12 started dropping because your stomach acid declined from years of stress and coffee on an empty stomach. Your folate utilization shifted because you've got an MTHFR variant you've never been tested for. Your homocysteine crept up quietly. Your SAMe production fell off. And now you can't focus. You're irritable for no reason. You have this low-grade brain fog that never fully clears. Caffeine used to sharpen you up and now it just makes you anxious. You forget why you walked into rooms. You used to read for hours and now you can't finish a paragraph You went to your doctor and he said "that's just getting older." Maybe prescribed something for focus or anxiety. Probably didn't test homocysteine. Definitely didn't test methylmalonic acid or run a functional B12 panel You're running a cofactor bottleneck in the one-carbon metabolism cycle that controls how your brain makes, uses, and clears every neurotransmitter you rely on to function. Actually fixing it: Get homocysteine tested. If it's above 8 you have a methylation issue whether you "feel" it or not Active B vitamins (methylfolate + methylcobalamin + P5P). Not the cheap cyanocobalamin garbage in your CVS multivitamin that your body can barely convert Creatine. Handles roughly 40% of your methylation burden and takes pressure off the whole system Eat enough protein. Methionine from animal protein feeds the cycle. Vegans and undereaters run dry here first Glycine and collagen. Glycine is the biggest consumer of methyl groups in the body. Supplementing it directly reduces demand on the cycle Fix the gut (obviously). B12 absorption requires intrinsic factor and adequate stomach acid. If your gut is wrecked, oral B12 barely touches it Your biochemistry is running on empty and every doctor you've seen has mistaken a nutrient bottleneck for time passing. I break down the full methylation pathway, what to test, and exactly how to restore it on my substack. link in bio

@signulll Rapid weight loss plus celebrity buccal fat removal.

why does ozempic caused the “ozempic face”? what’s the distinctive science behind why you can almost always tell if someone lost weight due to ozempic vs naturally?

One of the biggest life lessons you can learn: Motivation isn't real. Momentum is.

It's ready. I spent the past few months obsessing over the knowledge gaps vibe coders have in trying to learn to build real software. Then built a curriculum to start turning the vibe coders into engineers. It's 35 modules/projects, 250+ interactive lessons. Link in reply.

The reason I mention this is because we are heading into a world where you make no decisions. You experience what others want you to, no thinking. No choosing, just clicking what they think you should see.

@sudoingX @boquetrapo but who plays the game?

@boquetrapo interstellar odyssey pitched down 15%. the 9B writes the code, i pick the soundtrack.

hear this anon you don't need a $4,699 box to get started local AI. use what you already have first. test your workload. this is what a $250 GPU did today. iteration 3 of octopus invaders is here. 4 phases. 6 prompts. zero handwritten code. the same 9B on the same 3060 fixed its own enemy spawning, patched a dual start conflict, added level progression, resized every bullet, and when the browser cached old files it figured that out on its own and added version parameters to force reload. 3,200+ lines across 13 files. every line by qwen 3.5 9B Q4 at 35-50 tok/s on 12 gigs through hermes agent. understand what your load actually needs before you build. don't get trapped by influencers selling you boxes next to a plant. test on what you have. then decide. this 3060 impressed me in ways i did not expect and its autonomy is what kept me going. now its time to move to new experiments on other nodes and other models for all of us. if you are running this setup the exact stack, flags, and open source code, exact prompts i used are in the replies. if you run into issues let me know. seeing students and builders discover hermes from my posts and start running local is why i do this. full autonomous build at 8x speed in the video. gameplay at the end. watch it.