Jui Dave

#STROKE #OriginalResearch: @juimdave et al. discover that the TGFβ pathway represses angiopoietin-2 in brain pericytes during development and identify pericyte-derived angiopoietin-2 as a target for germinal matrix hemorrhage. #AHAJournals ahajournals.org/doi/full/10.11…

📢📢📢 Publication alert! 🧠🔬🧑‍🔬 Dave et al. identify that repression of Angiopoetin-2 via TGFb pathway in #brain pericytes is indispensable for the blood-brain-barrier development! @KathyMartinYale @GreifLab @YaleCVRC @JunichiSaito_ @LinaNtokou @YaleMed ahajournals.org/doi/abs/10.116…

👏Congratulations Dr. @kabir_inamul and colleagues for the latest article @NatureAging! "The #age of #bone marrow dictates the #clonality of smooth muscle-derived cells in #atherosclerotic #plaques" is now published👉 nature.com/articles/s4358…

Angiogenesis ❤️

Jui Dave, PhD, investigates potential therapeutic targets for obstructive arterial diseases, including supravalvular aortic #stenosis @GreifLab. Congratulations @juimdave on your Career Development Award from @AHAScience. buff.ly/3Pge6d4 @YaleMed @YaleIMed

@LinaNtokou @MilliporeSigma Just saw this!! You are most welcome :)

Thank you @juimdave 🥰 #SheDiscovers @MilliporeSigma

Congratulations to Raja Chakraborty on this exciting story and to all our wonderful collaborators! @juimdave @GreifLab @YaleCVRC @YaleCardiology

@KathyMartinYale @GreifLab @YaleCVRC @YaleCardiology Amazing work! So happy to be a part of it :)

The JAGGED1/NOTCH3 pathway induces pathological aortic changes in elastin-deficient models: buff.ly/3K5rfDM @GreifLab @KathyMartinYale @juimdave @LinaNtokou @seema_mital @YaleCVRC @YaleIMed #VascularBiology

Thank you Yale News for highlighting our work! @YaleIMed @YaleCardiology @YaleCVRC @GreifLab yaledailynews.com/blog/2022/02/1…

@KathyMartinYale @YaleMed @GreifLab Thank you @KathyMartinYale for providing excellent advice and expertise on this project, very fortunate to have you as our collaborator :)

Yale researchers identify potential therapeutic target for aortic stenosis m.yale.edu/v2r7 via @yalemed Congrats to @juimdave and @GreifLab! Glad to have been able to collaborate on this exciting story!

A study by @juimdave from the @GreifLab has identified the role of Notch3 in vascular development. In a laboratory setting, treatment with a pharmacological inhibitor or the genetic deletion of Notch3 has a restorative effect on the aortic wall. buff.ly/3370qiN @YaleMed

Postdoctoral fellow @JuiMDave aims to unravel the cellular and molecular mechanisms of cardiovascular disorders. She is the first author of a recent @Dev_Cell study: buff.ly/3IifskM @YaleMed @YaleIMed @GreifLab @YaleCVRC

Beautiful elastin fibers 🥰 #aorta #elastin #blood_vessel #vascular_wall #media #smoothmusclecells #development #blood #heart #FluorescenceFriday 🌈

@susan_redward Most aortic diseases have defects in elastin, suggesting that elastin is absolutely integral for healthy vessel function. The interesting thing is that all of the elastin in your body is synthesized only during birth and early age. This pool will last your entire lifespan :)

The amazing aorta! #medial_layers #vascular_wall #elastin #smoothmusclecells #epigenetics #development #FluorescenceFriday👍 #myfirstTweet😊😊😊

@susan_redward The green is the cell nuclei (center of the cell which holds DNA). The cells are arranged in concentric rings or layers and each layer is seperated by a protein called elastin (magenta fibers). The elastin renders elasticity and mechanical support to the aorta!

@susan_redward Hope your husband is doing well now. Imagine the aorta as cylinder which helps carry the blood from heart to remaining parts of the body. You are looking at the cylinder wall cross-section. Blue stain are smooth muscle cells which majorly make up the aortic wall.

@Chapman_Histo @amandameyerphd Yes, ofcourse! Magenta=elastin fibers (CF633 hydrazide, Sigma); Blue=alpha smooth muscle actin (SMA-FITC conjugated, Sigma); Green=5-methycytosine DNA modification (5mC, Cell Signaling). The image is pseudo colored. Good luck with the staining!

@juimdave @amandameyerphd Stunning photo. I'd love to know the antibodies/stains used, if you don't mind sharing?

@SGoulopoulou Thank you very much! :)