Kannan Lab ESBG

Read our latest @eLife publication with @Pseudoenzyme Eyers lab! Mechanistic and evolutionary insights into isoform-specific ‘supercharging’ in DCLK family kinases by Venkat, Watterson, Byrne, et al! elifesciences.org/articles/87958

Read our latest @LivUniBCSB kinase study with @kannanlab Redox Regulation of Brain Selective Kinases BRSK1/2: Implications for Dynamic Control of the Eukaryotic AMPK family through Cys-based mechanisms biorxiv.org/content/10.110…

Rayna Carter and Kennady Boyd from the Kannan lab receive summer internships to work on the NIH common fund project on "Illuminating the Druggable Genomes", Congratulations!

New publication on the prevalence of pneumococcal serine-rich repeat proteins, critical for the development of a protein vaccine. Led by Javid Aceil and Aarya Venkat in a joint collaboration with Fikri Avci at Emory! #Bioinformatics #epidemiology journals.asm.org/doi/10.1128/sp…

New preprint out on DCLK family #kinases and their unique modes of autoregulation. Joint effort led by Aarya Venkat, Grace Watterson, and Dominic Byrne. Great collaboration with @Pseudoenzyme and @ClaireEEyers! biorxiv.org/content/10.110… #Bioinformatics #biochemistry #AlphaFold

Leading the session at #ASBMB on Tuesday afternoon for computational biology! Will be giving a talk on protein function prediction and classification using deep learning models and knowledge graph mining. #bioinformatics #machinelearning

Our graduate student Aarya Venkat (aaryakat.com) gave a spotlight talk at the ASBMB conference yesterday on the evolution of glycosyltransferases! #glycotime #evolution

We have a new paper out, an explainable deep learning model for #kinase phosphosite prediction, enabling substrate predictions at the whole kinome level. #bioinformatics #MachineLearning #DeepLearning #Biochemistry Link to paper: #authorNotesSectionTitle" target="_blank" rel="nofollow noopener">academic.oup.com/bioinformatics…

The second paper is on using these protein language models for embedding-based tree visualizations, orthogonal to (but consistent with) sequence-alignment based approaches. Useful for capturing relationships for difficult-to-align protein families: academic.oup.com/bib/article/24…

Two new papers out in Briefings in Bioinformatics. The first on an alignment-free approach for estimating sequence conservation using sequence embeddings made from protein language models: academic.oup.com/bib/article/24… #Bioinformatics #MachineLearning #AI

Proud of our undergraduate lab member, Grace Watterson, who presented an excellent talk on her work on DCLK kinases at the Harden conference in the UK. #kinase #bioinformatics

Congratulations to our graduate student Aarya Venkat (@aaryakat) for winning a poster award for his research at the 2022 @SFGlycobiology conference!! #glycotime

Thanks to everyone who made @BiochemSoc 88th #Harden meeting such a huge success. It was a pleasure to have so many team members and collaborators under one roof, including our newest collaborator from @kannanlab

Congratulations to our grad student Maya Salcedo for recieving the @ARCSFoundation scholarship! @ARCS_Atlanta #biochemistry #WomenInScience

Congratulations to George Bendzunas, a postdoc in our lab, for winning first place in the poster competition at the Winship Cancer Retreat. His poster was titled "Heterodimerization Provides a Pathway for Regulation of the BRSK Dark Kinases." #kinase #IDG #biochemistry #cancer

Congrats to Aarya Venkat @aaryakat in our lab for his recently accepted paper on the modular evolution of fold A glycosyltransferases (GT-As). Here's a neat conception of our model for GT-A evolution. #glycotime #Bioinformatics #biochemistry jbc.org/article/S0021-…

Congratulations to our lab's own Dr. Wayland Yeung for successfully defending his dissertation, titled "Traditional and representation learning approaches for protein sequence analysis." #bioinformatics

It was another great session, thanks @CyertMartha for coming, and for the exciting talks on pseudophosphatases from @Sharpe_Lab, glycogen synthase complex from @zeqiraj and the endless possibilities of glycosyltransferases from @kannanlab

@andy___jones Aww thank you!

Every paper I see coming out of the Kannan lab looks great!