karan
2.5K posts



Here’s a secret that every genuinely original thinker knows: there are no original ideas. there are only original combinations. Every “breakthrough” is two existing ideas from different domains meeting for the first time inside someone’s head. The person who reads only within their field will only ever have ideas that their field has already had. This is why the most interesting people are almost always polymaths. Go wider. Read the thing that has nothing to do with your work. Talk to the person who has nothing in common with you. Visit the place that makes no sense on your itinerary. The irrelevant input is the one that will combine with everything else and produce something nobody’s ever seen.


Sleeping <6h a night for 2 weeks reduces cognitive performance equal to 2 nights of total sleep deprivation.




this is actually insane > be tech guy in australia > adopt cancer riddled rescue dog, months to live > not_going_to_give_you_up.mp4 > pay $3,000 to sequence her tumor DNA > feed it to ChatGPT and AlphaFold > zero background in biology > identify mutated proteins, match them to drug targets > design a custom mRNA cancer vaccine from scratch > genomics professor is “gobsmacked” that some puppy lover did this on his own > need ethics approval to administer it > red tape takes longer than designing the vaccine > 3 months, finally approved > drive 10 hours to get rosie her first injection > tumor halves > coat gets glossy again > dog is alive and happy > professor: “if we can do this for a dog, why aren’t we rolling this out to humans?” one man with a chatbot, and $3,000 just outperformed the entire pharmaceutical discovery pipeline. we are going to cure so many diseases. I dont think people realize how good things are going to get





















