Elijah Kirschstein retweetledi

🚨 New publication alert in @Cancer_Cell from @gunderlab & team!
Their study revealed that #myofibroblast programming (the most common fibroblast phenotype in #pancreatic_cancers) transcriptionally represses differentiation into fibroblastic reticular subtypes that are necessary to form #tertiary_lymphoid_structures in #tumors.
Blocking these myofibroblast differentiation signals combined with agonizing lymphotoxin beta receptor reverses this, thereby inducing TLS and promoting anti-tumor immunity.
🧠These findings help us understand how to overcome resistance to TLS formation order to increase response to #immunotherapy.
Congratulations to the team!
Read More: cell.com/cancer-cell/fu…
@OhioStateSurg @OhioStatePIIO

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