Pelotonia Institute for Immuno-Oncology

Lalita and I were honored to be part of the ceremony installing Dr. @KimrynRathmell, CEO of @OSUCCC_James, as the Jeri B. Block and Robert H. Schottenstein Distinguished Chair in Cancer. We’re fortunate to have attracted a leader of Dr. Rathmell’s caliber to lead Ohio State’s efforts to create a cancer-free world, and we are deeply grateful to generous partners like Jeri and Bobby Schottenstein whose visionary support advances excellence across Ohio State. Endowed chairs like these position us to continue to attract and retain the world’s top talent, translating to life-changing and life-saving work that benefits all Ohioans.

💡 New insights in #LungCancer research from #PIIO member Dr. @DCarboneMD & colleagues. Their Phase III analysis identified clinical & biomarker factors linked to early outcomes with first-line nivolumab + ipilimumab in metastatic #NSCLC, helping advance more personalized #immunotherapy. 🫁🔬 Read more: pubmed.ncbi.nlm.nih.gov/42360104/

🌟 Advancing #BreastCancer research! A new study from #PIIO members Dr. @NandiniAacharya, Dr. Ramesh Ganju, Dr. Jonathan Song, & colleagues reveals that induced electric fields (iEFs) remodel the #tumor_immune_microenvironment while limiting tumor growth and #metastasis. Findings support iEFs as a promising non-invasive immunomodulatory strategy for metastatic #TNBC.🔬⚡ Learn more: pubmed.ncbi.nlm.nih.gov/42325544/

Congratulations, Dr. Ringel!

📢 New Publication Alert! 🎉 Congrats to #PIIO members @TMaceLab, @QinMaBMBL & colleagues on developing ParSlet, a prevalence-aware feature selection framework that improves microbiome biomarker identification, enhancing the reliability and reproducibility of disease-associated microbial signatures. 🦠🔬 Read more: pubmed.ncbi.nlm.nih.gov/42340677/

Congratulations to @AkEisfeld and the statisticians at the Bloomfield Center on their contributions to this major collaborative study in @NatImmunol, shedding light on the pathology and consequences of leukemic tissue infiltration. 👏 nature.com/articles/s4159…

🚀 Get ready for an exciting #PIIO research-in-progress seminar on KIR Acquisition During Human #NKCell Development 📅 July 8 | 🕛 12 PM | 📍 EAIC 130  🎤 Noah Koenigs, PhD candidate (Aharon Freud Lab) Cutting-edge science + breakthrough insights—be there! @OSUCCC_James

Congratulations 👏🏽🎉 Dr. Alinari! Well deserved!

🎉 Congratulations Dr. @StoverLab & Team!

👏Congrats to our recently promoted faculty members! @AsrarAlahmadi

Dr. Mims is heading to NYC this July for @gotoPER Medical Crossfire®: Hematologic Malignancies She is looking forward to thoughtful discussion on CAR T, AML, and more. Use her code: Mims for free HCP registration: tinyurl.com/43fz3bbf

👏 Congrats to our Medical Oncology faculty selected for the 26-27 @OhioStateMed FAME FLI cohort @MariumHusain @LoganRoofMD @royaryam

Congratulations to #PIIO/@OhioStateNeuro Recruit Dr. @NandiniAacharya on receiving her first @theNCI R01 Grant! Her research explores how #glioblastoma hijacks peripheral trigeminal sensory circuits to establish an #immunosuppressive #tumor_microenvironment by instructing #tumor_associated_macrophages and driving #CD8⁺ #Tcell dysfunction. By uncovering the molecular logic of this #neuroimmune circuitry, the work seeks to develop fundamentally new strategies to overcome #immunotherapy resistance through repurposing FDA-approved #nociceptor-modulating therapies. @OSUCCC_James @Pelotonia

🚨New Publications featuring #PIIO Member @NandiniAacharya. Two new @ImmunityCP papers co-authored by Dr. Nandini Acharya uncover fundamental mechanisms that shape #Th17 cell identity and function. These findings advance our understanding of how Th17 cells integrate environmental, metabolic, and intracellular cues to drive #immunity, #inflammation, & #cancer, opening new avenues for future #immunotherapies. sciencedirect.com/science/articl… sciencedirect.com/science/articl…

Some stories remind us why we do this work. This is one of them. Beautifully written, deeply human, and a powerful reminder that behind every breakthrough are decades of courage, persistence, and hope. If pancreatic cancer—the Shadow—can be wounded, then hope exists for every cancer still waiting for its breakthrough. Here's to the scientists, clinicians, patients, and advocates who refuse to give up. The future feels closer than ever.

Exciting work from @OSUCCC_James (@Zihai Li Lab) identifies ZFP148 as a hidden brake on cancer-fighting #Tcells. Remove the brake, unleash stronger #immune responses, and move one step closer to more effective immunotherapies. 🧬🛡️ #CancerResearch #Immunotherapy #BuckeyeScience

Today marks 100 days since the opening of the new #OSUWexMed University Hospital! 🏥 To celebrate this milestone, we are sharing an exclusive look at our journey with a before-and-after photo gallery: wexnermedical.osu.edu/our-stories/un… 📸 @ohiostateap and Walsh Turner

🚨 Another major milestone for #CancerImmunotherapy research at @OhioStatePIIO! Congratulations to @DrSTANtheMAN on receiving a new #NCI R01 award to advance groundbreaking research on #mitochondrial reprogramming in #tumor_associated_macrophages & new strategies to overcome tumor-driven #immunosuppression. This important work has the potential to uncover new therapeutic approaches that strengthen #AntiTumor_Immunity & improve outcomes for patients with #cancer. Congratulations, Dr. Huang, & the entire research team! 👏

Future cancer breakthroughs include inspiring #FutureScientists. 🔬 Today, #PIIO postdoctoral researcher Dr. Jay Mandula (@Zihai Lab) welcomed @OSUCCC_James CAMELOT students to the @Pelotonia Research Center, sharing his journey into #CancerResearch and highlighting how #ImmunoOncology is transforming patient care.

Proud to see our PhD student, @MostafaIHA, present his work on the single-cell and spatial landscape of RCC brain metastases @OSUCCC_James @OhioStatePIIO @Pelotonia. Using single-nucleus RNA-seq, spatial transcriptomics, and computational biology, his research explores mechanisms of immune dysfunction and therapeutic resistance in CNS metastases. Excited to see this work advance our understanding of brain metastasis biology and precision oncology. #KidneyCancer #BrainMetastases #SingleCell #SpatialTranscriptomics #PrecisionOncology #HasanovLab #OSUCCC #CodeToClinic