Cote lab-The KAT in the HAT

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Cote lab-The KAT in the HAT

Cote lab-The KAT in the HAT

@lab_hat

Research on chromatin linked to gene regulation and genome stability

Québec, Canada Katılım Eylül 2018
307 Takip Edilen663 Takipçiler
Cote lab-The KAT in the HAT
Cote lab-The KAT in the HAT@lab_hat·
Gairdner International Symposium on Cell Signaling in Cancer-great success and first event in our new research building. Outstanding talks and discussions, thanks to @GairdnerAwards and @AxeOnco for their support, and Emilie, Anne-Marie, Michel and Nicolas for their hard work.
Cote lab-The KAT in the HAT tweet mediaCote lab-The KAT in the HAT tweet mediaCote lab-The KAT in the HAT tweet mediaCote lab-The KAT in the HAT tweet media
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Siavash Kurdistani
Siavash Kurdistani@VashKurdistani·
I wrote a memoir for Michael Grunstein, a pioneer in histone biology and epigenetics, for ⁦⁦@theNASciences⁩. Read about his incredible personal journey and how his career unfolded. nasonline.org/directory-entr…
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Cote lab-The KAT in the HAT
Cote lab-The KAT in the HAT@lab_hat·
La date limite d'inscription approche, moins de 2 semaines... et c'est gratuit! Registration deadline getting close, less than 2 weeks... and it is free!
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Cote lab-The KAT in the HAT@lab_hat·
Indeed, clearly supporting the idea that NuA4/TIP60 does not use the same molecular mechanism as SRCAP to engage nucleosomes in order to incorporate H2A.Z. The multiplicity of histone mark reader modules in NuA4 likely playing a role.
The Nogales Lab@NogalesLab

Please also take a look at related work by @rklouder and Carl Wu at @HopkinsMedicine diving into different functional states of the human SRCAP remodeler and a comparison with TIP60. Recently out in @biorxivpreprint biorxiv.org/content/10.110…

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Cote lab-The KAT in the HAT
Cote lab-The KAT in the HAT@lab_hat·
So happy this is finally out. Fantastic collaboration with @NogalesLab to obtain high resolution structure of the human NuA4/TIP60 complex and investigate the function of the TRRAP subunit in recruitment. science.org/doi/10.1126/sc…
The Nogales Lab@NogalesLab

In humans, the essential TIP60 complex is a fusion of 2 molecular assemblies that in yeast perform different functions: -NuA4 ➡️ a histone acetyltransferase. -SWR1 ➡️ a chromatin remodeler that incorporates H2A.Z in promoter and enhancer-proximal nucleosomes. 🛠️🧬

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Cote lab-The KAT in the HAT
Cote lab-The KAT in the HAT@lab_hat·
@doyonlab ours is coming out tomorrow... only TIP60, a few 3 liters preps along the way, from the cell lines from Cell Rep 2015 (doi.org/10.1016/j.celr…)... I see that they were not able to get NCP-bound TIP60 structures either... we tried with different substrates
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Raquel Cuella Martin
Raquel Cuella Martin@raquel_cuella·
Is anyone interested in coming to work with the amazing crowd at the Cuella Martin lab and our cool projects? An RA position will open soon, stay tuned!
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Andy Truman PhD
Andy Truman PhD@TrumanLab·
Can anyone recommend a company that has a service to endogenously epitope tag or mutate proteins in mammalian cell lines using CRISPR or similar?
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Whetstine Lab
Whetstine Lab@WhetstineLab·
Thanks Scott & Hong as well as @VAInstitute organizing committee for a super meeting so far. It has been great talking science related to #epigenetics & establishing collaborations with colleagues & those attending. We also appreciate how well you treated us!
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Keşfet

@GairdnerAwards @AxeOnco @theNASciences @ICR_London @CRC_ULaval @facmedUL @crchuqc @chudequebec