Gary Owens Lab UVA
70 posts
Gary Owens Lab UVA
@lab_owens
UVA based cardiovascular research lab, SMC enthusiasts
Charlottesville, VA Katılım Haziran 2018
143 Takip Edilen452 Takipçiler
Gary Owens Lab UVA retweetledi
Mouse Model of Spontaneous Heart Attack and Stroke @sohelszaman @beccadeaton @lab_owens @UVACVRC @AnitaSalamon_ ahajournals.org/doi/full/10.11…
English
Excited to see our publication in press @CircAHA complete with a fantastic editorial by @Const_Delwarde @AikawaAikawaLab . Our study was featured in this week’s Circulation on the Run podcast. Congratulations @sohelszaman, @beccadeaton and co-authors! ahajournals.org/doi/full/10.11…
English
Thanks for the excellent summary of our recent work @HaoYin20 ! Congratulations to @sohelszaman and @beccadeaton and all their coauthors for this fantastic study. @UVACVRC
Hao Yin@HaoYin20
A mouse model of #Atherosclerosis (SR-BI∆CT/∆CT;Ldlr−/− + #WesternDiet) mimics late-stage events of human disease😎 👉75% #MyocardialInfarction 👉38% #Stroke 👉31% #PlaqueRupture Similar lipid & liver enzyme profile to Ldlr-/-🐭except for 45% low HDL-C & body weight Does this mouse have distinct SMC lineage trajectories from Ldlr-/-🐭? 😁 +Therapeutic effects of AZM198, myeloperoxidase inhibitor AZM198-> ⏫Sox9+Col2a1+ SMC subset (~5-fold!😮Re-thinking the role of the osteochondrogenic SMCs?) ⏫Contractile SMC subset ⏬Klf4+Egr1+ modulated SMC subset @lab_owens @CircAHA 2024 ahajournals.org/doi/abs/10.116…
English
Congratulations to Dr. Karnewar and co-authors!
ATVB: An AHA Journal@atvbahajournals
IL-1β promotes atherosclerosis but paradoxically is also required for diet-induced regression of advanced lesions and maintenance of a protective fibrous cap @InnovatieHester @gamze_b_bulut @beccadeaton @DiezBenavente ahajrnls.org/3KnnkV7
English
Gary Owens Lab UVA retweetledi
IL-1β promotes atherosclerosis but paradoxically is also required for diet-induced regression of advanced lesions and maintenance of a protective fibrous cap @InnovatieHester @gamze_b_bulut
@beccadeaton @DiezBenavente
ahajrnls.org/3KnnkV7
English
One of our two newly funded projects!
UVA School of Medicine@MedicineUVA
Gary Owens, PhD, was awarded a $3.2 million grant to study the role of IL-6 trans signaling in atherosclerosis development, which can cause heart attacks and strokes. @UVACVRC @uvahealthnews #UVASchoolofMedicine news.med.virginia.edu/research/gary-…
English
Gary Owens Lab UVA retweetledi
February Featured Article: A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_ ahajrnls.org/3Y3ZIJT
English
Today we celebrate the amazing women in the Owens Lab in honor of International Day of Women and Girls in Science @Anita_Salamon_ , Victoria Milosek, @beccadeaton , Noelle Koo, Alex Krinsky, Rupa Tripathi, Laura Shankman #internationalwomenandgirlsinscienceday #whorunstheworld
English
Gary Owens Lab UVA retweetledi
A new autosomal Myh11-CreERT2 mouse allows inclusion of both sexes in SMC lineage-tracing and gene-knockout mouse studies @gamze_b_bulut @Anita_Salamon_
ahajrnls.org/3FzJjFs
English
We are excited to share our new autosomal Myh11-CreERT2 mouse model to enable smooth muscle cell specific KO & lineage tracing in both MALE & FEMALE mice!
(Previous 🐭 was Y-linked)
@atvbahajournals @beccadeaton
English
@HaoYin20 @atvbahajournals Thank you for the shoutout! We are exited to see what new things can be discovered using this new model.
English
An autosomal (Chr2) Myh11-CreERT2🐭model to enable #SmoothMuscleCell-specific KO & lineage tracing in Both MALE & FEMALE!👍
(Previous mouse Myh11-Cre transgenes are Y-linked)
Dr. Gary Owens lab @atvbahajournals 2022 @lab_owens
ahajournals.org/doi/10.1161/AT…
English
Gary Owens Lab UVA retweetledi
A new study led by Dr. Gary Owens (@lab_owens) at @MedicineUVA has determined the function of Lgals3-transitioned inflammatory smooth muscle cells in #atherosclerosis.
📌 Read more: bit.ly/3QKMHCd
English
Gary Owens Lab UVA retweetledi
🏆 Best of #NatMetab2021 | CITATIONS
#18
Exploring the origins of myofibroblasts in atherosclerotic fibrous caps, @lab_owens (@UVA), @aacnewman13 (@nyulangone), @DrVladPhD, @ScientistBaylis find that smooth muscle cells are required for plaque stability.
nature.com/articles/s4225…
English
Gary Owens Lab UVA retweetledi
Many heart attacks and strokes are caused by unstable atherosclerotic plaques, which accumulate in our arteries. Researchers believe they could strengthen the plaque's fibrous caps and prevent these conditions. newsroom.uvahealth.com/2021/03/23/dis… @UVACVRC @AmericanHeartVA
English