Xin Lan👩🏻‍🔬

Progenitor exhausted CD8 T cells (Tpex) can undergo self-renewal without antigen. But how does continued antigen exposure impact their self-renewal capacity during an anti-tumor response? Does attenuated TCR stimulation slow down the terminal differentiation of Tpex?

Next week ImmuneZoom seminar #350.

@itsyogeshd @jiyang_yu Big congratulations, Yogesh!!!!!!

San Francisco Downtown hit 66° today. #CAwx

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis or other (non-LCH) histiocytic sarcomas cases. I'm trying to understand non-surgical chemo and targeted therapy options, new pathology markers to better diagnose subtypes/treatments, and any data on progression in pediatric patients. Please feel free to share – I’m trying to cast a wide net due to the rarity of this condition and how little is known. People can contact me directly at my first name (as written in my profile) at octant.bio.

Why do some inflammatory bowel disease patients benefit from anti-TNF therapy whilst others do not? Our new @NatImmunol resource paper investigates this question by following patients before and after treatment: nature.com/articles/s4159… 👇

And for now, we can only say "until we meet again". See you all next time in Memphis ;)

@Husultan @washupathedu @NateraGenetics @parkerici Beautiful work

I am pleased to share with you that my paper has been accepted in Nature rdcu.be/dOPyr This work would not have been possible without the guidance of an exceptional mentor, support of awesome lab members and collaborators. @washupathedu @NateraGenetics @parkerici

Thank you for the nice summary of our study!

@Bingyu_Science Thank you!

Progenitor exhausted CD8 T cells (Tpex) can undergo self-renewal without antigen. But how does continued antigen exposure impact their self-renewal capacity during an anti-tumor response? Does attenuated TCR stimulation slow down the terminal differentiation of Tpex?

@StJudeResearch @NatImmunol #peer-review" target="_blank" rel="nofollow noopener">nature.com/articles/s4159…

I'm grateful for the unconditional support from all the co-authors, Ben, and our lovely lab family @StJudeResearch . Thank @NatImmunol for the opportunity to publish our findings. Read rdcu.be/dJv9K for more.

A new Review contextualizes what is known about the developmental trajectory of T cell exhaustion—a state that arises during cancer and chronic infections. @lan_xlan7 @CaitlinZebley @StJudeResearch scim.ag/3XY

@Bingyu_Science Thanks, Bingyu!

Thank you for highlighting our review!

highlight the epigenetic changes that occur at distinct stages of exhaustion, along with key contributors to this epigenetic remodeling. Last, we discuss how recent findings from basic research on the subset specification of T cell exhaustion can inform therapeutic design.

and the regulation of subset transitions by the three canonical T cell signals from TCR, co-stimulatory/ inhibitory receptors and cytokines. We also summarize the roles transcription factors play in specifying exhausted T cell subsets and

Check out our latest review on T cell exhaustion @SciImmunology @StJudeResearch science.org/doi/10.1126/sc…