Nadiah Wan

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Nadiah Wan

Nadiah Wan

@lapetitemaligne

An itinerant mind with a professional interest in health and a vast curiosity for anything else. Views here are my own.

KL Katılım Temmuz 2009
1.3K Takip Edilen6.9K Takipçiler
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Furkan Gözükara
Furkan Gözükara@FurkanGozukara·
Iran just published a new Lego animation that will make Israel and Lego company so furious They named it as "Modern Elephant Companions" Those who doesn't know this majestic historic event @grok explain
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Philip Proudfoot
Philip Proudfoot@PhilipProudfoot·
China has just produced the best possible use-case for AI. The Epstein Wars as crafty Persian cats vs an arrogant and stupid golden eagle
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Nadiah Wan
Nadiah Wan@lapetitemaligne·
The world is going to find out we all can’t actually eat silicone wafers.
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Hank Green
Hank Green@hankgreen·
Look, I'm not an oncologist but I am frustrated by the way this dog cancer story is being interpreted from a bunch of different angles and I think basically all of this can be cleared up if people understood like...six things. You should know these 6 things about cancer:
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Nadiah Wan
Nadiah Wan@lapetitemaligne·
Super exciting time to be in biotech
Anish Moonka@AnishA_Moonka

Every time you get a cancer biopsy, the lab makes a tissue slide that costs about $5. It shows the shape of your cells under a microscope, and every cancer patient already has one on file. There’s a much fancier version of that test called multiplex immunofluorescence (basically a protein-level map showing which immune cells are near your tumor and what they’re doing). It costs thousands of dollars per sample, takes specialized equipment most hospitals don’t have, and barely scales. But it’s the kind of data oncologists need to figure out whether immunotherapy will actually work for you. Right now, only about 20 to 40% of cancer patients respond to immunotherapy, and one of the biggest reasons is that doctors can’t easily tell whether a tumor is “hot” (immune cells actively fighting it) or “cold” (immune system ignoring it). Microsoft, Providence Health, and the University of Washington trained an AI to analyze the $5 slide and predict what the expensive test would show across 21 different protein markers. They called it GigaTIME, trained it on 40 million cells in which both the cheap slide and the expensive test coexisted, and then turned it loose on 14,256 real cancer patients across 51 hospitals in 7 US states. The results landed in Cell, one of the most selective journals in biology. The model generated about 300,000 virtual protein maps covering 24 cancer types and 306 subtypes. It found 1,234 real, verified connections between immune cell behavior, genetic mutations, tumor staging, and patient survival that were previously invisible at this scale. When they tested it against a completely separate database of 10,200 cancer patients, the results matched up almost perfectly (0.88 out of 1.0 agreement). Nature Methods named spatial proteomics (mapping where specific proteins sit inside your tissue) its Method of the Year in 2024, and specifically cited GigaTIME in a March 2026 update as a model that “democratizes” this kind of analysis. The full model is open-source on Hugging Face. Any cancer research lab with archived biopsy slides, and most of them have thousands, can now run virtual immune profiling without buying a single piece of new equipment.

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Nadiah Wan
Nadiah Wan@lapetitemaligne·
asteriskmag.com/issues/12-book… Fascinating. Am going to get copies of Jin Yong.
afra wang@afrazhaowang

an organizer from a student book club at a European STEM university is planning a reading group around this piece, The China Tech Canon (initially published on @Asterisk Magazine last year) and invited me to join their discussion. it’s genuinely very endearing to know the essay has traveled that far, and that people are taking the time to read it closely and talk about it together!

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Interesting STEM
Interesting STEM@InterestingSTEM·
They capture the exact moment when a developing heart shifts from silence to its first beat. There is no “switch”: many cells gradually become active and, upon crossing a critical threshold, the entire tissue suddenly synchronizes.
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Hadi Azmi
Hadi Azmi@amerhadiazmi·
Good luck convincing brilliant Malaysians to enter public service. It’s rarely worth it. Too often you become collateral damage in political intrigue. Better to take the well-paying job far from the corridors of power and live in peace.
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Shanaka Anslem Perera ⚡
Shanaka Anslem Perera ⚡@shanaka86·
The President of the United States just acknowledged, publicly, that the Strait of Hormuz is closed not by missiles but by insurance. Read that again. The most powerful military on earth, mid-campaign, with air superiority over Iran, with carrier strike groups deployed, just announced that the solution to the Hormuz crisis is not more bombs. It is a federal insurance backstop. Trump ordered the US Development Finance Corporation to provide political risk insurance for all maritime trade through the Gulf, effective immediately. Navy escorts for tankers through Hormuz “as soon as possible.” This is the strongest possible counter-move to the thesis I have been mapping all day. And it confirms every word of it. The DFC is a development finance institution. Its mandate is financing projects in developing countries. It has never underwritten maritime war risk insurance. It has no actuarial models for Gulf transit. It has no treaty reinsurance behind it. It has no claims-handling infrastructure for vessels struck by Iranian drones in an active war zone. The President ordered it to do something it has never done, in a domain it has no expertise in, effective immediately. Compare this to what it is replacing. The twelve P&I clubs that cover 90% of global tonnage have spent decades building war risk models, capital reserves, claims networks, and regulatory compliance under Solvency II. They exited the Gulf in 72 hours because the risk became unmodelable. Trump is proposing to replace that entire architecture with a development finance agency and a presidential order. Now the Navy escorts. The 1980s Tanker War used exactly this template under Operation Earnest Will. It took seven months to organise. It worked because private insurance stayed intact throughout. Premiums rose but coverage was never withdrawn. The escorts supplemented the insurance market. They did not replace it. This time the insurance market has exited. Escorts without underlying coverage do not solve the problem, because P&I clubs require war risk cover to be in place before a vessel can legally trade. A Navy destroyer sailing alongside a tanker does not satisfy Solvency II capital requirements for the reinsurer sitting in London. The announcement will move oil prices. It should. The signal that the US government recognises the problem is meaningful. But the gap between a presidential order and an operational insurance programme that forty-plus independent syndicates, twelve P&I clubs, and five major reinsurers will accept as adequate replacement coverage is measured in months, not hours. The market heard “effective immediately.” The insurance industry heard “we have no idea how this works but we will figure it out.” Those are two very different timelines. The thesis holds. The President just confirmed the mechanism by trying to solve it. The solution itself reveals the problem’s scale. open.substack.com/pub/shanakaans…
Shanaka Anslem Perera ⚡ tweet media
Shanaka Anslem Perera ⚡@shanaka86

The Strait of Hormuz did not close because of missiles. It closed because seven insurance companies filed paperwork. Between March 1 and 2, seven of twelve P&I clubs insuring 90% of the world's ocean-going tonnage issued 72-hour cancellation notices for Gulf war risk. Transits collapsed 80%. Forty-plus supertankers sit idle. Thirteen LNG tankers diverted. The world's most important energy chokepoint shut down by spreadsheet, not by strike. This is 2008 repo transferred to a new substrate. In September 2008 banks stopped lending not because they were insolvent but because verifying counterparty solvency cost more than the overnight loan was worth. Identical mechanism. Gulf reinsurers cannot model the risk. So they did not reprice. They withdrew entirely. A military blockade ends when the campaign ends. An actuarial blockade ends when reinsurers decide it has ended. Those are fundamentally different timelines. Brent at $79 prices a four-to-eight-week disruption. The evidence supports six to eighteen months for full insurance reinstatement. The Red Sea never even triggered full P&I withdrawal and premiums remain elevated two years later. The 2008 repo market took twelve to eighteen months to normalise with TARP behind it. The maritime insurance market has received nothing. March 5, midnight GMT. Cancellation notices take effect. Zero commercially insured vessels transit Hormuz after that without a government backstop that does not yet exist. Four to sixteen months of unpriced duration sitting in plain sight. If I am wrong: Hormuz transits recover above 70 vessels per day within 14 days of March 5. Brent sustains below $75 for five sessions. A multi-flag government backstop is announced within seven days. Until then, $79 is not pricing a temporary disruption. It is pricing a misunderstanding. Full 8,000+ word analysis on Substack - open.substack.com/pub/shanakaans…

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Gaurav Dalmia
Gaurav Dalmia@gdalmiathinks·
Good piece on China's young elite.
Gaurav Dalmia tweet mediaGaurav Dalmia tweet media
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Nadiah Wan
Nadiah Wan@lapetitemaligne·
Sendin dua to our brothers & sisters in the Middle East. During this month of Ramadan many had also travelled to Mecca & there must be many worried kin. May we remember as humans to value restraint, compassion, wisdom & discipline like the Prophet Muhammad PBUH.
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Eric Topol
Eric Topol@EricTopol·
🆕 @NatureMedicine How does ChatGPT Health do for appropriately triaging a person as to whether to go to the emergency room or stay home? nature.com/articles/s4159… Not very well. Under-triaged 52% of case vignettes that are considered gold-standard emergencies, like diabetic ketoacidosis or impending respiratory failure
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kit
kit@yungkit14·
@lapetitemaligne @boosulyn I'm confused with poultry as in like do we consider frozen chicken to be part of madani.. if yes I should have bought loose pack
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