Leandro Bugnon

1.9K posts

Leandro Bugnon

Leandro Bugnon

@lbugnon

Machine learning & bioinformatics @sinc_i.

Santa Fé, Argentina Katılım Nisan 2010
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Milstein
Milstein@MilsteinmAb·
Ayer desayunamos con la noticia de que Paul habia encontrado la "cura milagrosa" al mastocitoma de su perra Rosie con USD 3000 y usando ChatGPT/AlphaFold. Pero, ¿esto realmente es así? Les comparto mi análisis, junto a una introducción del resto los protagonistas de esta historia.
Trung Phan@TrungTPhan

Australian tech entrepreneur Paul Conyngham explains how he used ChatGPT/AlphaFold (spent $3,000 with no biology background) to create a custom MRNA vaccine to treat his dog’s cancer tumors. Unreal.

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G@__endut__·
Recién depositado mi sueldo de docente universitario de Febrero. Cargo simple, 40 hs/mes. Me pagan $4570 la hora. Pero no tenemos que hacer paro porque los estudiantes 👍
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Instituto sinc(i) - UNL/CONICET
Instituto sinc(i) - UNL/CONICET@sinc_i·
🕵🧬🖥 How to computationally annotate protein domains in Pfam? Check out our new paper! 📣 Introducing GNN2Pfam: a new model based on Graph Neural Networks, published in @JStructBiol
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Damián Catanzaro ☕️
Damián Catanzaro ☕️@DamianCatanzaro·
Enero aun no terminó y se siente exactamente asi y esto es de lo que quiero hablar, mes a mes esto va a ir creciendo exponencialmente, por que? Porque programar herramientas requiere cada vez menos tiempo entonces mes a mes van a aparecer cada vez mas herramientas las cuales van a ser hypeadas hasta la muerte. Lo importante de esto es saber separar, dejen de darle bookmark a todo si ustedes mismos saben que no lo van a leer, no se mientan, no se sobrecarguen por querer aprender las 120 herramientas vibecodeadas que salen por dia, investiguen las que realmente les interese y no se estresen al pedo.
GREG ISENBERG@gregisenberg

POV: January 2026

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Leandro Bugnon
Leandro Bugnon@lbugnon·
Mande 3 diseños que se expresaron aunque no resultaron buenos binders, es un montón lo que se puede hacer con boltz gen y optimización bayesiana
Adaptyv Bio@adaptyvbio

The results of the Nipah Protein Design Competition are out! 🧬 1200 proteins experimentally validated (3x more than last year) 📈 99 novel binders against the target protein (a challenging tetramer with little prior work) 💪 26 single digit nM or better binders, with the best ones at single-digit picomolar affinity! All data now available open-source on Proteinbase! Let's take a look at the results ⬇️

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Kevin K. Yang 楊凱筌
Kevin K. Yang 楊凱筌@KevinKaichuang·
We were promised programmable biology but we got indecipherable programming instead
Jake Feala@FealaJake

Every biologist needs to try vibe coding, they're perfectly trained for it. Who else is totally comfortable prodding alien, indecipherable blobs with vague incantations, watching them slosh and churn with only the foggiest mental model of the intricate yet sloppy machinations churning inside the box. Then getting wildly surprising outputs that you then have to patiently corral toward something that’s, if not exactly what was in mind, at least an interesting and useful creation

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Boltz
Boltz@boltz_bio·
Hello World 👋 Today we are unveiling Boltz PBC, a Public Benefit Corporation to advance AI for biology through open science, and make it accessible to every scientist building a healthier future. Follow to stay up to date, and read more on our manifesto: boltz.bio/manifesto
Gabriele Corso@GabriCorso

Big news from Boltz today: we’re launching Boltz Lab, a new platform with new small-molecule + protein design agents, announcing Boltz PBC and a $28M seed round, and sharing a multi-year partnership with Pfizer. More below! 🚀

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Leandro Bugnon
Leandro Bugnon@lbugnon·
Obvio que la universidad va a contratar a la sociedad turbia de la IA para dar cursos antes que mejorar las condiciones de la planta 😁
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Andrej Karpathy
Andrej Karpathy@karpathy·
I've never felt this much behind as a programmer. The profession is being dramatically refactored as the bits contributed by the programmer are increasingly sparse and between. I have a sense that I could be 10X more powerful if I just properly string together what has become available over the last ~year and a failure to claim the boost feels decidedly like skill issue. There's a new programmable layer of abstraction to master (in addition to the usual layers below) involving agents, subagents, their prompts, contexts, memory, modes, permissions, tools, plugins, skills, hooks, MCP, LSP, slash commands, workflows, IDE integrations, and a need to build an all-encompassing mental model for strengths and pitfalls of fundamentally stochastic, fallible, unintelligible and changing entities suddenly intermingled with what used to be good old fashioned engineering. Clearly some powerful alien tool was handed around except it comes with no manual and everyone has to figure out how to hold it and operate it, while the resulting magnitude 9 earthquake is rocking the profession. Roll up your sleeves to not fall behind.
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Leandro Bugnon
Leandro Bugnon@lbugnon·
Por si no tenían temas para preocuparse 😅
Andrew Hessel@andrewhessel

@pdhsu There are some scary proteins out the there — venoms, neurotoxins, prions, etc. Protein engineering tools will need some guardrails, too.

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Leandro Bugnon@lbugnon·
@proteinbase A misleading part of the evaluation (probably intentional to avoid score hacking) is that many good candidates are lost when only submission avg ipSAE is reported. I just found now diverse candidates with .88 ipsae />80 plddt on different submissions
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Proteinbase
Proteinbase@proteinbase·
The Best ipSAE Award goes to Nick Boyd for his protein 'noble-swan-clay' with a whopping score of 0.92! We received many questions about how ipSAE is calculated - we'll share the exact methods and the reasoning behind in an email to participants soon proteinbase.com/proteins/noble…
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Proteinbase
Proteinbase@proteinbase·
The protein design competition community vote is now open! This edition, we received over 11,000 proteins from over 600 designers. That's more than 5x increase from our last competition. In other words, there's a lot to explore! How to vote: ➡️ Head to proteinbase.com 🧐 Browse the submissions ⭐ Star your favorites You can vote for as many as you'd like. The top submissions (up to 200 proteins in total) based on community votes will be experimentally tested in the lab. Voting closes December 10th 11:59 PM PST .
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Leandro Bugnon
Leandro Bugnon@lbugnon·
Este año fue un laburazo del team bioinfo del @sinc_i, se vienen cosas interesantes!
Instituto sinc(i) - UNL/CONICET@sinc_i

El @sinc_i dice presente en la I Jornada Argentina de Bioinformática y Biología Computacional (IJAB2C) de la @a2b2c . 💻🧬🧠 En esta ocasión becarios del Instituto realizaron presentaciones de sus trabajos en formato oral y póster.

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LA NACION
LA NACION@LANACION·
Cáncer de piel: ya está disponible la vacuna argentina para tratar el melanoma de alto riesgo #Echobox=1763986750" target="_blank" rel="nofollow noopener">lanacion.com.ar/sociedad/cance…
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OTRO DÍA PERDIDO
OTRO DÍA PERDIDO@otrodiaperdidok·
La historia de perseverancia de Tamara Rubilar: Su hijo tenía una enfermedad autoinmune y ella encontró la cura con erizos de mar. 🔬 #OtroDiaPerdido
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Mile Sikic
Mile Sikic@msikic·
AI-for-biology is becoming one of the toughest places to publish. Output in mainstream ML is exploding, but biology-focused AI moves slower—and students feel the pressure first. 1/12
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Keşfet

@JStructBiol @proteinbase @sinc_i @YazaGames @_wholesomegames @_Melimelum_ @elonmusk @BarackObama