Luke Simpson

Nature research paper: Identification of an allosteric site on the E3 ligase adapter cereblon go.nature.com/4k1h5qX

Pour a glass of champagne AND red Bordeaux—Our newest work with @GSK and @scrippsresearch is out in @Nature, where we describe SB-405483, the first allosteric CRBN ligand which potentiates neosubstrate degradation. Congrats Vanessa and all authors! 🍷💫💐 nature.com/articles/s4158…

Opening applications for a Principal Scientist, Computational Cancer Biology at @Boehringer! Drive cutting‑edge computational oncology, advance MoA insights, shape biomarker‑driven patient selection, and turn multiomics + clinicogenomics into discoveries. lnkd.in/drAJwSBC

Online now! Deciphering phosphorylation TACtics: Advances in phosphorylation targeting strategies and bifunctional modalities dlvr.it/TQLYGz #chembiol

Join us! Research Technician position available in Sapkota lab ppu.mrc.ac.uk/careers/recrui…

I am delighted to see our D2B approach for CNS-active degrader discovery is online . KH1 is identified as a rapid, potent and highly selective in vivo active chemical probe. For details: nature.com/articles/s4146… @FarnabyLab @dundeeuni @UoDCeTPD

Online now! A method for the detection and enrichment of endogenous cereblon substrates dlvr.it/TMRqjR #chembiol

& to all the fantastic colleagues I had the pleasure to work with during this time! Keep continuing to #innovate, #collaborate & #inspire, and I look forward to seeing all the amazing science when it comes out! ✨

After an incredible 3.5 years, I recently finished my time at @UoDCeTPD, working as part of the CeTPD-Boehringer Ingelheim PROTAC collaboration team. A huge thank you to Kirsten, @farnaby84 & @alessiociulli for the opportunity to join the Team and all your guidance throughout,

📖 The June-July Journal Club edition is out! Thanks to Aileen, Hiro, Ilaria and Mokhitli, great job editors! Don’t miss out on the latest news in TPD, have a look at the new edition of the Journal Club! buff.ly/aneibz0 #openaccess #TPD #journalclub @UoDLifeSciences

Pleased to share Dr Nur Kocaturk has been awarded a Cross-Sector Experience Award from @acmedsci This funding will allow them to collaborate with Promega Corp to co-develop a new cellular ligand finding platform for intractable disease related proteins.

@nurkocaturk @acmedsci Woohoo! Huge well done, Nur, very well deserved! 💪✨

Proud to have been awarded a Cross-Sector Experience Award from @acmedsci 🏆. This funding will allow me to establish a new bridge between academia and industry to make innovations and advance my research on small molecule drug discovery in CNS. Stay tuned for the updates 📣

#NEWS: We're proud to share the @US_FDA has accepted our first-ever New Drug Application with @Pfizer for an investigational PROTAC ER degrader for patients with ESR1-mutated, ER+/HER2- advanced or metastatic #BreastCancer. Read the full release: bit.ly/41BcovV

Heads up for those working in ubiquitin biology and targeted protein degradation—Lorne Ubiquitin 2025 is happening 20–23 November in Lorne, Victoria, Australia. Late abstracts are still being accepted—worth checking out!!! 🦘🦘🦘

Excited to share with you our latest preprint on SMARCA2/4 degraders! at the @UoDCeTPD in collaboration with #GeorgWinter´s lab. Here, we show how a Molecular Glue Degrader can covalently and redundantly recruit DCAF16 and FBXO22 to degrade SMARCA2/4 biorxiv.org/content/10.110…

New work introducing PCIPs, heterobifunctional chemical inducers of proximity that inhibit DNA repair by recruiting BET proteins to PARP2. Great work uncovering a new form of event-driven pharmacology by Bryce/Eric/Erin and the rest of the team. (1/3) biorxiv.org/content/10.110…

🧩 New paper out in Nature Communications! "Unveiling the hidden interactome of CRBN molecular glues" Huge thanks to our incredible team and collaborators who made this possible! 📖 Read the full open-access article here: nature.com/articles/s4146…

Our proteomics group is looking for a Scientist  who is excited to push the boundaries of chemoproteomics and interactomics at Dana‑Farber! Apply at the link or message me with questions! careers.dana-farber.org/job/11894/scie…

Delighted to share that a project 'Green PROTACs – Enabling Small Molecule (Re)programming and Manipulation of Plant Biology' by Dr Piers Hemsley @Hemsley_Lab, Professor @alessiociulli and Dr @HajkDrost has been funded through this scheme.

Branched ubiquitin chains significantly expand the ubiquitin system's signalling capacity. In this #BiochemSocTrans review, McFarland et al. discuss the emerging tools and methods for studying the roles of branched chains in diverse cellular processes.doi.org/10.1042/bst202…