Chris Lupton

Thrilled to see our work out in @Nature on the #cryoem structure of LYCHOS! A monumental effort from co-first author @bj_charles, the @Dr_Ellisdon Lab, the @Dr_MLHalls Lab from @MIPS_DDB, @HariVenugopal2 from @CryoEM_Monash. nature.com/articles/s4158…

Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex #science #publication #research #journal lifescience.net/entries/829259…

Absolutely thrilled to see our latest study online @CellCellPress. Structure of the lysosomal KICSTOR-GATOR1-SAMTOR nutrient-sensing supercomplex. doi.org/10.1016/j.cell… @LuptonCJ @Dr_MLHalls & Andrew Ellisdon. #cryoEM #KICSTOR #mTORC1 #GATOR1

🍃➡️🧬 First paper from the Martynowycz Lab! Spontaneous seed-protein nanocrystals → 0.85Å ab-initio structure of crambin by #MicroED No crystallization screens, no MR bias. Watch the diffraction-to-density movie & grab the preprint below! biorxiv.org/content/10.110…

Excited to share the N&V @RobertoZoncu and I wrote for @NatureSMB on the recent surge of LYCHOS structure papers! 🚀 We propose a unifying model that ties together these new discoveries. It’s incredible to see so much momentum building on our work. nature.com/articles/s4159…

@bluesocks81 @youtubemusic PJ Harvey - Catherine CCR - Fortunate Son Metallica - Ride the Lightning Neil Young - Old man Chris Cornell - Nearly forgot my broken heart Tom Waits - Heart attack and vine

@bluesocks81 @youtubemusic You've covered a lot of what I'd put down but some additions off the top of my head that have been on my radar lately: Mulatu Astatke - Nostalgia Hannes Bieger - Apollo Toto - Rosanna Yellow Magic Orchestra - Rydeen Ben Salter - The Translator Beastie Boys - Sabotage

So my bandmates wanted me to prepare a "Stream of Consciousness" playlist. It turned into a bit of an epic one, but its more of an insight into my very ecclectic musical influences. Check it out! music.youtube.com/playlist?list=… via @YouTubeMusic

Amidst the chaos, here's a belated but exciting highlight on the recent LYCHOS structure by @bj_charles @LuptonCJ @Dr_Ellisdon @Dr_MLHalls @RobertoZoncu and I broke down their findings, explored future directions, and tackled the key remaining questions. authors.elsevier.com/c/1kZRC3SNvcEP…

We are hiring! The Formosa Group is hiring a Research Officer to join our program on #Mitochondria, #Metabolism & #MitochondrialDisease @MonashBDI! 💡If you're passionate about mitochondrial research or know someone who is, please share! Apply now: careers.pageuppeople.com/513/cw/en/job/…

🚨 Save the Date! 🚨 I'm thrilled to announce the Prato Conference on Pore Forming Proteins, happening this June in the stunning city of Prato, Italy! 🙏 Please share or repost this to help us reach as many people as possible—especially those who would love to attend!

🧵 1/ We’re excited to share that our new paper with @adrianbracken lab is out 🎉 In this study (which began 10 years ago!) we explore the biology of PRC2 and PRC1 in non-dividing cells. We also explore the effects of PRC2 inhibitor drugs on these cells. Here’s what we found👇

Thrilled to see our work on high-resolution #cryoem using a common LaB6 120-keV TEM and sub–200-keV direct electron detector, now online @ScienceAdvances. science.org/doi/10.1126/sc… . A collaboration with @GatanMicroscopy, @GeorgRamm, and @CryoEM_Monash.

Update! We outline AIVE, an AI method for volume EM data. We show the benefits of AIVE for reconstructing your FIB-SEM data, reveal some fascinating cell biology, and define intrusions as a new form of mitochondrial contact. biorxiv.org/content/10.110… Muscle mito nanotunnels 1/3🧵

Great to see our work on the #cryoem structure of the human TSC:WIPI3 lysosomal recruitment complex in @ScienceAdvances! Awesome effort from co-authors @bj_charles and @sci_laura with @Dr_Ellisdon doing the heavy lifting leading the project. science.org/doi/10.1126/sc…

🚨 Our story on the TSC:WIPI3 lysosomal-recruitment complex is now live in @ScienceAdvances . Equal-first co-authors @LuptonCJ & @sci_laura. Work lead by @Dr_Ellisdon. Funding from @DeptofDefense & @arc_gov_au. science.org/doi/10.1126/sc…

Highlighted today in @CellCellPress a great perspective piece about our recent work on LYCHOS. @arshukla and colleagues raise interesting points about membrane cross talk! cell.com/cell/abstract/…

Delighted to share our preview article now published in Cell @CellCellPress where we highlight the beautiful LYCHOS story from @Dr_Ellisdon and team, published recently in @Nature! Bound by the love for cholesterol: A transporter meets a GPCR: Cell cell.com/cell/fulltext/…

Nature research paper: LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR go.nature.com/3zKOh3i

@bhusalrp @Nature @bj_charles @Dr_Ellisdon @Dr_MLHalls @MIPS_DDB @HariVenugopal2 @CryoEM_Monash Thanks, Ram!

@LuptonCJ @Nature @bj_charles @Dr_Ellisdon @Dr_MLHalls @MIPS_DDB @HariVenugopal2 @CryoEM_Monash Outstanding work! Congratulations Charles, Chris, Andrew and co.

Thrilled to see our work out in @Nature on the #cryoem structure of LYCHOS! A monumental effort from co-first author @bj_charles, the @Dr_Ellisdon Lab, the @Dr_MLHalls Lab from @MIPS_DDB, @HariVenugopal2 from @CryoEM_Monash. nature.com/articles/s4158…

👇Read on to find out about a fascinating #GPCR acting as a domain of a larger transmembrane protein at the lysosome, important for regulation of #mTOR A wonderful collaboration with @Dr_Ellisdon between @MIPS_DDB @MIPS_Australia and @MonashBDI, and a huge effort from our teams