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@makerisafer
Mom of 3 one with FUS-ALS P525L, RN BSN, art lover, @MomsDemand, hobby photographer, blood donor🩸 cyclist 🚴🏻♀️,#endals, grandma 💙 ♥️ #jacifusen #nurown
Katılım Temmuz 2012
2.1K Takip Edilen1.9K Takipçiler

@WayButterfield I have no idea, I never heard anything like it
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Officials confirmed that two people have died and eight others are in critical condition following a mass shooting at Brown University in Providence, Rhode Island. Authorities say the situation remains active as police continue searching for the shooter or shooters.
A shelter in place order is still in effect while law enforcement secures the campus and investigates. Officials have urged the public to avoid speculation and wait for verified updates as the situation develops.
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Active shooter scene at Brown University in Providence, Rhode Island.
Alertpage, Inc@alertpage
BROWN UNIVERSITY (PROVIDENCE,RI) **ACTIVE SHOOTER** POLICE REQUESTING AS MANY RESCUES AS THEY CAN GET FOR MULTIPLE VICTIMS - CLEARING THE BUILDING AND FINDING ADDITIONAL VICTIMS #BREAKING
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Tap here to help me get products on TikTok for $0! You can also join me for a chance to get your favorite TikTok Shop products for free! Terms & Conditions apply. tiktok.com/t/ZTH34f86CGW7…
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Tap here to help me get products on TikTok for $0! You can also join me for a chance to get your favorite TikTok Shop products for free! Terms & Conditions apply. tiktok.com/t/ZTH34fRp16kf…
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BREAKING: Donald Trump did NOT win the Nobel Peace Prize.
Venezuelan opposition leader María Corina Machado received the Nobel Peace Prize for promoting democratic rights in her country.
“When authoritarians seize power, it is crucial to recognize courageous defenders of freedom who rise and resist”, the Norwegian Nobel Committee said in its citation.


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Two Minnesota state lawmakers—Sen. John Hoffman and Rep Melissa Hortman—and their spouses were shot overnight by someone impersonating a police officer, according to media.
ABC News@ABC
BREAKING: Two Minnesota lawmakers in grave condition after apparent "targeted" shooting, officials say. abcnews.link/cR1gLSW
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"Five draft deferments, zero combat - but sure, let’s have a military parade.”
#NoKings
#NoKingsInAmerica

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Police in Brooklyn Park, MN confirm suspect in multiple shootings is impersonating law enforcement. Shelter-in-place issued near Edinburgh Golf Course. Sen. John Hoffman (D) and Rep. Melissa Hortman (D) were shot overnight at their homes. Conditions unknown. 😲
NTC Report@NTC_Report
Police in Brooklyn Park, Minnesota confirm suspect in multiple shootings is dressed like law enforcement. Shelter in place order in 3 mile radius of Edinburgh Golf Course. Suspect is white male, brown hair, armed and dangerous.
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Live updates: Brooklyn Park shelter-in-place after multiple shootings, suspect may be impersonating police | FOX 9 Minneapolis-St. Paul #trumpsamerikkka fox9.com/news/brooklyn-…
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Tap to get your TikTok Shop coupon tiktok.com/t/ZTjVHe6CD/
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Can you name the four most common genetic subtypes of ALS? SOD1, FUS, C9orf72,TARDBP. Did you know only 5-10% of ALS is genetic? Will understanding these DNA abnormalities unlock future treatments, not just for genetic ALS, but for all ALS? How about the other 90% and ALS prevention? We need a PLAN to understand and eliminate environmental risk factors too and we are not spending a proportional amount on prevention. PDPlan.org
Key Points:
- Nice comment in Lancet and series in Lancet Neurology.
- ALS isn’t a single disease.
- The most common genetic culprits are SOD1, FUS, C9orf72, and TARDBP.
- Each genetic subtype paints us a different picture of how motor neurons may die.
- Tofersen, targeting SOD1, may slightly slow progression in trials.
- FUS-related ALS is showing response to jacifusen, an antisense therapy now in phase 3.
- C9orf72 remains the biggest genetic piece of the puzzle and it accounts for ~40% of familial ALS.
- TDP-43 pathology is present in nearly all ALS cases and tackling TDP-43 is a huge challenge.
My take: Each subtype of ALS offers a lens into motor neuron vulnerability. Could therapies that fail in one potentially guide success in another? What do we need to do? Predict risk, slow onset and prevent disease. Should we consider universal genetic testing in ALS, regardless of age or family history? Every clue matters. Why should we care about the environment in ALS? Environmental exposures (e.g., pesticides, heavy metals, military related toxins, viral infections) may all possibly act as triggers or accelerators. Remember clues to cause, could also be clues to prevention. The environmental risk factors will likely help us to piece together why ALS develops and how we might prevent it, especially in the vast majority of people without known genetic mutations. Environmental exposures can affect how genes are turned on/off without changing the DNA sequence. We call this field epigenetics. Unlike genes, environmental exposures can be changed, regulated, or avoided. Understanding both genetics and environment will be essential to unlocking ALS.
thelancet.com/journals/laneu…
#ALS #ALSResearch #GeneticMedicine #Tofersen #Jacifusen #Neurodegeneration #TheLancet #C9orf72 #TDP43 #SOD1 #FUS #PrecisionMedicine #GeneTherapy @alsassociation

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BREAKING: The group behind the MASSIVE “Hands off” protest is now calling for another protest on April 19.
In social media posts, the group stated that they want 3.5 percent of the U.S. population—more than 11 million people—to participate. They cite this figure as the threshold for "sustained resistance in order to make a difference."
Spread the word!
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