Malte Gersch

Interested in Ubiquitin, Parkinson’s disease therapy, mitochondria or DUB inhibitors? This preprint may be for you: We show how the deubiquitinase USP30 can specifically be inhibited & introduce a framework for DUB ligandability. biorxiv.org/content/10.110… Thread👇 – with movie!!

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@Amelie_HJ @TU_Dortmund @uniallianz Welcome, @Amelie_HJ, it‘s fantastic to have you here!

2024 was a pretty exciting year for the group and 2025 starts with a bang as I'll become the chair of hybrid bionanosystems and full professor (W3) for chemistry and chemical biology @TU_Dortmund and the Research Centre One Health Ruhr @uniallianz - so excited for what's to come!

@werner_achim @nchembio Thanks, Achim!

@MalteGersch @nchembio Congratulations!!!

Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…

@rbdamgaard Thank you, Rune!

Congratulations, Malte and team!

Excited to report our discovery of an important component of the oxidative stress response, the E3 ligase TRIP12. It acts as a chain elongation factor that amplifies CUL3-KEAP1 activity to drive NRF2 degradation as cells recover from stress. biorxiv.org/content/10.110…

@DuccioConti @nchembio Thanks, Duccio!

@Schroeterfisch Thank you, Christian!

Congratulations to the whole team, impressive work!

Let‘s (re)connect at 🦋 if you like: bsky.app/profile/malteg…

Excited that our work on transcription-coupled DNA repair is now published @CellCellPress! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸 ➡️ cell.com/cell/fulltext/…

Excited to share this work led by @CamillaElb where we identify an entirely new role of LUBAC as a critical regulator of AMPK, the energetic stress response, and cellular metabolism. If you are interested in #ubiquitin and #metabolism, have a read: biorxiv.org/content/10.110…

Thanks very much, @MalteGersch, for inviting me to the @mpimoph. I had a great time in Dortmund!

@SLorenzLab @mpimoph Thank you @SLorenzLab for your visit and exciting seminar!

@UZH_Chemistry @Hartrampf_Lab Congrats Nina, this is fantastic! 🥳

Congratulation to Nina @Hartrampf_Lab @UZH_Chemistry 👏👏👏

Enjoying the #EMBOubiquitin2024 meeting in beautiful, sunny Cavtat with this lot @jnpruneda @Elliott_Lab_Ox @MalteGersch @YKulathu

Applications are welcome, please share 📢

@DuccioConti Thanks Duccio!

Interested in Ubiquitin, Parkinson’s disease therapy, mitochondria or DUB inhibitors? This preprint may be for you: We show how the deubiquitinase USP30 can specifically be inhibited & introduce a framework for DUB ligandability. biorxiv.org/content/10.110… Thread👇 – with movie!!

@alessiociulli @NikolasKlink @gallant_kai @mpimoph @TU_Dortmund @IMPRS_LM @crc1430 Thanks Alessio, much appreciated!

@MalteGersch @NikolasKlink @gallant_kai @mpimoph @TU_Dortmund @IMPRS_LM @crc1430 Beautiful work Malte, Niko and team, congrats! 🥳

@LeoKiss5 Thanks Leo!

The study also establishes chimeric protein engineering to aid DUB crystallization – maybe a crystallization rescue strategy for other challenging enzymes, too? We are excited to share this work & hope you will enjoy reading the preprint. We look forward to comments!

This study is the result of persistent work and heroic efforts by Nafizul Kazi (on the far left in the picture). Chemistry by @NikolasKlink, cellular assays by @gallant_kai and Gian. Thank you for support by @mpimoph, @TU_Dortmund, @IMPRS_LM, @crc1430 .