Niko Klink

132 posts

Niko Klink banner
Niko Klink

Niko Klink

@NikolasKlink

PhD candidate @Gerschlab at the CGC of the @MPImoph and @TU_Dortmund. Fascinated by drug discovery and all things Ubiquitin.

Katılım Eylül 2022
188 Takip Edilen105 Takipçiler
Niko Klink
Niko Klink@NikolasKlink·
Excited to share that our work on Parkinson's target USP30 has been published in Nature Structural & Molecular Biology! By combining DUB-domains onto USP30, we for the first time achieved crystallization with a small molecule (NK036) without Nanobodies! nature.com/articles/s4159…
English
0
2
6
204
TU Dortmund
TU Dortmund@TU_Dortmund·
Achtung Achtung: Die Sperrung am Vogelpothsweg aufgrund der Abrissarbeiten am Bibliotheksgebäude ist nun wieder aufgehoben. Somit halten auch die Busse wieder wie gewohnt an den üblichen Haltestellen unter der Mensabrücke.
TU Dortmund tweet media
Deutsch
1
0
0
400
Niko Klink
Niko Klink@NikolasKlink·
@alessiociulli @J_A_C_S I remember telling you in a pub in Barcelona that im a big fan of this story :D Great to see this finally out, congrats to the whole Team!
English
1
0
2
269
Alessio Ciulli
Alessio Ciulli@alessiociulli·
Happy to share that this work is now published in the Journal of the American Chemical Society @J_A_C_S pubs.acs.org/doi/10.1021/ja…
Alessio Ciulli@alessiociulli

Excited to share our latest work combining VHL and CRBN in a single trivalent PROTAC to boost protein degradation. Great #TPD collaboration with @georg_e_winter and Kristin Riching, led by @AdamBond_ Miquel & Celia in each lab @UoDCeTPD @CeMM_News @promega doi.org/10.26434/chemr…

English
1
6
90
9.9K
Niko Klink retweetledi
Malte Gersch
Malte Gersch@MalteGersch·
Very excited to share that our manuscript on the "Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53" was published today at Nature Chemical Biology @nchembio. Congratulations Kim, Kai, and all authors! nature.com/articles/s4158…
Malte Gersch tweet media
Malte Gersch@MalteGersch

For all ubiquitin, deubiquitinase and chemical biology aficionados: Here's a preprint from the lab introducing 2 new active DUBs in humans & a unique type of DUB activity one would miss with the widely used panels of free ubiquitin chains. t.ly/GnRVv Thread👇(1/10)

English
3
14
114
11.5K
Niko Klink retweetledi
CRC 1430
CRC 1430@crc1430·
Tomorrow, November 26, we are looking forward to hosting @georg_e_winter from @CeMM_News, Austrian Academy of Sciences, Vienna, at @crc1430 @unidue. Join us for his exciting talk on small-molecule degraders!
CRC 1430 tweet media
English
0
1
6
426
Niko Klink retweetledi
nature
nature@Nature·
“We’re very excited to see what people do with this” AlphaFold3 is open at last go.nature.com/4fHAfio
English
21
592
1.7K
128.1K
Niko Klink
Niko Klink@NikolasKlink·
I had such a great time at this years AEK autumn school on #degraders and bringing them towards clinical applications. Fantastic Talks from both academia and Industry. I learned alot, got to see old friends and made New ones. Im bringing home great memories and a bunch of notes!
Niko Klink tweet media
English
0
0
3
415
Niko Klink
Niko Klink@NikolasKlink·
@HartungIngo When one candidate does everything to hinder and downtalk science, i personally think the circumstances where a science journal could get involved are met
English
1
0
1
191
Niko Klink retweetledi
Ubiquigent
Ubiquigent@ubiquigent·
We’re delighted to be partnering with @AlleoLabs to accelerate DUB-focused drug discovery! This collaboration will combine Alleo’s AI-based platform with our expertise in the DUB space to advance DUB-focused preclinical programmes. ➡ tinyurl.com/283d7o5o
Ubiquigent tweet media
English
0
2
3
239

Keşfet

@MalteGersch @maxplanckpress @Nature @giuliosf @alessiociulli @CellChemBiol @TU_Dortmund @J_A_C_S