Rune Busk Damgaard

More evidence that LUBAC has functions beyond immune signalling. Our recent study shows that LUBAC and OTULIN regulate metabolic signalling: specifically they govern AMPK signalling to control metabolic adaption, autophagy, and cell death during energetic stress. This suggests that the metabolic symptoms observed in patients with LUBAC deficiency and ORAS, including glycogen storage disease, lipodystrophy, and liver disease, may be caused directly my metabolic dysregulation rather than being secondary to the systemic inflammation. nature.com/articles/s4141…

@BarteltLab Overall, I agree. But the power of the programme boards/committees, who request the evaluations, are not to be underestimated.

@rbdamgaard 🤣🤣🤣 tru dat - no frame of reference but for the most part critical difference is that reviewer #2 has more power over you 😜

I’d take a full review from a grumpy Reviewer #2 any day over student teaching evaluations. Students are savage.

@luijsterburglab Fine, good. So your original statement does not hold for your own papers. Why did you say it? We all use judgment in what we cite but blanket policies against citing preprints are unethical and antithetical to good science.

@metapredict @BarteltLab I think it is clear who is mocking whom.

@rbdamgaard @BarteltLab Yet you mock the native speaker rather than admit you didn't think or perhaps recognise the nuance of 'context''. Spent nearly 5yr in Sweden & Denmark and you all absolutely do JUST (21st Century) fine with basic english. Accents are irrelevant but nice try at gaslighting👋

Why not cite preprints? They are published, the data are there for everyone to see. Why ignore the latest data of out of principle?

@metapredict @BarteltLab Yes, English is my second language. I also have an accent. Somehow I do quite fine.

@rbdamgaard @BarteltLab It's not; but you are nicely illustrating the issue of non-native english speakers missing nuances. Data is out there isn't a euphemism for "publishing" either - we clearly distinguish between data release and 'publishing' in science. Your last sentence lacks clarity.

@metapredict @BarteltLab I know what it means to publish. Your point is semantic and moot. The data is out there for everyone to see. Just assess it rather than dismiss out of principle.

@rbdamgaard @BarteltLab That is a high school definition of "publish" - ie literal. As you know, "publish" in science implies a multi step process. English is nuanced. Preprints are accessible, should now be cited (regrettably) & I absolutely agree much of (genuinely) published work is complete shite

@metapredict @BarteltLab They are published. They are just not peer reviewed. A lot of what’s published by your definition of that word is 💩 too. Just read it and assess it. As you do with anything else. I find it problematic to not cite preprints just because they are preprints.

@rbdamgaard @BarteltLab They aren't "published" - that term in science means something distinct (in english at least). Saying that the horse has bolted and now everyone cites esp in informatics. (the reason not to is obvious; u can pre-print anything including made up 💩like myokines....oh wait)

@KehatLab @BarteltLab I understand your point, but I don’t agree that it’s a useful way to do it. I am in favour of preprints, but not as the sole mechanism of publication. We need peer-review.

@rbdamgaard @BarteltLab This will help break the impact factor bubble, which I don’t think advances science

@KehatLab @BarteltLab I see your point, but I don’t think that makes sense once the peer-reviewed version is published.

@rbdamgaard @BarteltLab Maybe we should site the pre-print even after the paper is published in a ‘conventional’ journal. The pre print is the prior science

More evidence that LUBAC has functions beyond immune signalling. Our recent study shows that LUBAC and OTULIN regulate metabolic signalling: specifically they govern AMPK signalling to control metabolic adaption, autophagy, and cell death during energetic stress. This suggests that the metabolic symptoms observed in patients with LUBAC deficiency and ORAS, including glycogen storage disease, lipodystrophy, and liver disease, may be caused directly my metabolic dysregulation rather than being secondary to the systemic inflammation. nature.com/articles/s4141…

@WW3finalboss @grok is this a true quote?

🇺🇸🇳🇴🇮🇷 Speech at the White House this morning. “If the Prime Minister of Norway had given me the Nobel Peace Prize, our submarine wouldn’t have had to sink an Iranian ship…” — Donald Trump, President of the United States

Exciting to have our findings out after peer review!!! The skin generates sex steroids in nanomolar to micromolar amounts, depending on the sex steroid and the skin site. Specifically skin androgens regulate S. aureus quorum sensing.

New ad by the Norwegian Consumer Council: "A Day in the Life of an Ensh*ttificator"

The UK sacrifices its research lead to uphold an unsustainable University funding system and the naiv view that less University research equals more growth in the private sector This is a mistake that will be much, much more expensive in the long run researchprofessionalnews.com/rr-news-uk-uni…

🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it? Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear. Our new paper in @cddpress uncovers one. 🧵👇 nature.com/articles/s4141…

This project started with confusion 🤔 nature.com/articles/s4141… Loss of LUBAC or OTULIN causes inflammatory disease. But patients also show clear metabolic defects. Neither LUBAC nor OTULIN had been linked to metabolic regulation. So where do these metabolic symptoms come from?

We turned to proteomics 📊 and found that LUBAC and OTULIN regulate AMPK. This suggests the metabolic defects may not simply be secondary to inflammation. Rather, they may be central in the pathogenesis.