marco

Finally out in @NatImmunol our teamwork @MyUniSR @SanRaffaeleMi @UZH_en @UniGenova on age-induced alterations of granulopoiesis that worsen stroke pathology through the release of immature neutrophils. special thanks to @Becherlab and all collaborators ! nature.com/articles/s4159…

A deadly glioblastoma that’s long defied treatment just showed extraordinary responses in a Mass General trial that’s giving hope for #BrainCancer 🧠 Next-gen CAR-T therapy (dual-targeting EGFRvIII + wild-type EGFR) after one single infusion, all initial patients saw rapid tumor shrinkage, one nearly vanished, another ~60% reduction lasting months. Responses were temporary, but this proves a single dose can unleash powerful attacks on these tough tumors. Early days (phase 1 trial ongoing, more patients treated with promising safety), but a major step forward for immunotherapy in solid brain cancers. Source: Mass General / NEJM

@Pluchinolab @exosomeguy @NatMetabolism 🔝

Delighted to have written together with @exosomeguy this N&V for @NatMetabolism Cholesterol fuels microglia in chronic stroke nature.com/articles/s4225…

For those who haven't yet, go check out the hottest meeting in 2025... organized by the one and only @lai9uan & team. September 2025. Registration now open!

Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer’s disease model: Cell Stem Cell cell.com/cell-stem-cell…

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice | Nature nature.com/articles/s4158…

The diverse roles of neutrophils from protection to pathogenesis | Nature Immunology nature.com/articles/s4159…

There’s a WORLD day for almost everything, but today is WORLD Stroke Day, the one I hold most dear. This year, I can’t help but reflect on the social factors that influence health and stroke prevention WORLDwide. This issue deserves a spotlight: yes, in every corner of the WORLD.

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells | Nature Neuroscience nature.com/articles/s4159…

📢Ready for the best @KeystoneSymp ever on Innate Immune Memory (Feb 2-5, Vancouver)? @DrShrutiNaik @LabFairfax and I look forward to your hottest discoveries - Get your abstract in early for short talk consideration! pls RT #KSInnateImmune25 keysym.us/KSInnateImmune…

Embolic Stroke of Undetermined Source (ESUS) - thank you so much @SposatoL 🇦🇷 #neurotwitter #neurology #stroke #MedEd

BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses: Immunity cell.com/immunity/abstr…

Best meeting, best cells, best city, best organizers!! #PHAGOCYTE2025 👇👇👇

Did you ever wonder why the risk for subsequent vascular events is increased after a first stroke or MI? Our answer, out now in @Nature nature.com/articles/s4158… A story about NETosis, DNA-sensing and inflammasome activation. Spearheaded by @StefanRoth86 and Jiayu Cao.

1/8 Grateful and happy that our new story on the mechanism of #stroke recurrence in the context of large-artery #atherosclerosis is out in @nature. Big Thanks to our lab @ArthurLiesz @JiayuCao @ISD_Research and all esteemed authors to make it happen! DOI: doi.org/10.1038/s41586…

Back from a CRAZY race @EigerUltraTrail in the Swiss Alps. 250km, 15000m climbing, 84 hrs total, 3h sleep. As a scientist & ultrarunner, I wonder what new biology we'd find studying our body adaptation (good/bad) to extreme exercise. Anyone up for a crazy grant application? 😎

Finally out today! Very proud of this story: Innate immune memory after Stroke drives remote organ pathology This study was led by superstar-postdoc @SimatsAlba and X-less Sijia Zhang. @CellCellPress cell.com/cell/fulltext/…

@ArthurLiesz @SimatsAlba @CellCellPress Great work Arthur!!!

I am delighted to be part of this exciting virtual conference with @EACRnews on Cancer & Aging I December 3-4 👇👇

😍😍😍Brain-muscle communication prevents muscle aging by maintaining daily physiology | Science science.org/doi/10.1126/sc…

#inspiring lecture of Prof. Iadecola #ISA #stroke #2024