Marcus

1.4K posts

Marcus

@marcus_NJ

Senior Data Scientist at Relation Therapeutics | Hanc marginis exiguitās nōn caperet

London, England Katılım Haziran 2012

551 Takip Edilen187 Takipçiler

Marcus retweetledi

Stephanie Gaglione@Steph_Gaglione·28 Nis

Thrilled to share our preprint! We introduce TCRAFT, a method to assemble tens of thousands of TCRs at <$1 each, unlocking high-throughput functional TCR screening from single-cell data. 🧵@kochinstitute @MEBirnbaum @MITChemE @MIT biorxiv.org/content/10.110…

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Paddington@paddingtonbear·17 Şub

Nothing brightens a day quite like doing something kind for another person.

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Aleksejs Sazonovs@alehins·7 Şub

When Anaconda demand that you buy a per-user enterprise license for your HPC

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Marcus@marcus_NJ·26 Ara

@alehins NP level xmas problem

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Aleksejs Sazonovs@alehins·25 Ara

Had to educate everyone on the dangers of dimensionality reduction. Full shouting match. Christmas ruined.

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Bradley Harris@Bradleyomics·4 Kas

Thrilled to travelling to #ASHG2024 today! If you want to hear about how we can use large scale single cell RNA sequencing to better understand susceptibility to common complex diseases - drop by my talk on Wednesday!

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Marcus@marcus_NJ·28 Eki

Someone clearly removed HLA due to complex LD structure in the Cambridge plot

Megan Gozzard@PhDood1es

What geneticists fear the most: The Cambridge Plot.

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Marcus@marcus_NJ·8 Eki

@alehins That's what he won the Nobel for right?

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Aleksejs Sazonovs@alehins·8 Eki

There’s at least two days of omics Twitter discourse in this one

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Marcus@marcus_NJ·26 Eyl

@alehins is that equivalent to a 10 sample MR

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Aleksejs Sazonovs@alehins·26 Eyl

Think there should be some mural understanding that I’ll review more articles if you don’t send me five “a two-sample Mendelian randomisation study” manuscripts in a row

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Marcus@marcus_NJ·19 Eyl

@alehins Wow, they're going to put the pints on offer too alongside the renovation?!

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Aleksejs Sazonovs@alehins·18 Eyl

A wonderful move but it looks like I’m about to be charged £9 for a pint that I need to order with a QR code

Sadiq Khan@SadiqKhan

A sneak peek of how Oxford Street could look ⬇️

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Aleksejs Sazonovs@alehins·3 Eyl

I’d love to read the reaction to this on the Cell editorial slack

Jiankui He@Jiankui_He

I am willing to publish my two 2018 papers on the world first gene edited babies, however it must be published in either Nature or Science. It is one of the greatest medical breakthroughs in history, it deserves the honor to be published in Nature or Science.

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Marcus@marcus_NJ·2 Eyl

Where's Selena Gomez and Richard Thaler when you need them...

Nate Silver@NateSilver538

And P.S. you're probably going to have to get used to this. This market basically implies that the forecast is likely only going to be 60/40 in one direction or another by Election Day. polymarket.com/event/will-nat…

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Marcus@marcus_NJ·19 Ağu

Having been previously in this position with @anderson_carl and @FachalLaura, I can fully recommend it to those wanting to expand skillset, work on fascinating multi-omic datasets and be surrounded by a really motivated and smart team! sanger.wd103.myworkdayjobs.com/en-US/Wellcome…

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Marcus@marcus_NJ·31 Tem

@alehins *hatere

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Aleksejs Sazonovs@alehins·31 Tem

Passed my A1 Danish. It’s so over for you haters

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Marcus@marcus_NJ·30 Tem

@alehins "..."We didn't consider HLA due to its complex LD pattern leading to limited fine-mapping insights"

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Aleksejs Sazonovs@alehins·30 Tem

Coasting at a meeting preparing to drop a “have you looked at HLA?”

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Open Targets@OpenTargets·19 May

On #WorldIBDDay, Open Targets project lead @anderson_carl introduces our most ambitious project yet: @OpenIBD!

Wellcome Sanger Institute@sangerinstitute

Today is #WorldIBDDay 🌎 Check out our video with @anderson_carl to discover more about what IBD is and how @OpenIBD aims to find new ways to predict, monitor, and treat it.🔎 @OpenTargets @DrChrisLamb @UniofNewcastle @NewcastleHosps #IBDMythBusting sanger.ac.uk/news_item/ambi…

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Open Targets@OpenTargets·17 May

📣Introducing Open-IBD — our most ambitious project yet! @OpenIBD will bring together genomics and immunology experts, gastroenterologists, and patients from across the UK to identify new and personalised ways to predict, monitor, and treat inflammatory bowel disease

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Marcus@marcus_NJ·7 May

@alehins No option for B) modified by C)? What a garbage poll

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Aleksejs Sazonovs@alehins·7 May

It’s too close to call it just yet

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Aleksejs Sazonovs@alehins·7 May

Epistatic genetic interactions matter

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Marcus@marcus_NJ·22 Şub

@alehins People will post stuff like this on twitter and then just post the hla region to taunt you :( Bet you don't even LD prune the hits

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Aleksejs Sazonovs@alehins·22 Şub

The future of IBD genomics today at #ecco2024 First 5000 people to show up get an exclusive early access to the the next top 10 hits (#6 will surprise you)

Laura Fachal@FachalLaura

Just polishing the final details for our IIBDGC presentation at #ecco2024 I’m always up for a coffee and a chat about genetics!

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Aleksejs Sazonovs@alehins·22 Şub

.@FachalLaura rocking the room and casually announcing doubling the number of IBD associated signals, 500 candidate effector genes and 270 potentially causal proteins #ECCO24 #ECCO2024

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Marcus@marcus_NJ·20 Şub

@alehins Have you tried squinting your eyes while looking at the individual genotype calls

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Aleksejs Sazonovs@alehins·20 Şub

Imo there’s no great way of visualising the population structure in a sufficiently large and admixed cohort

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Keşfet

@kochinstitute @MEBirnbaum @MITChemE @MIT @alehins @anderson_carl @FachalLaura @elonmusk