Mark Begemann markbe
1.5K posts

Mark Begemann markbe
@markbe
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The aerobic vs anaerobic model is not wrong because it’s simple. It’s wrong because it implies a switch where there is only a continuum. Glycolysis is always active. Lactate is always produced and cleared. Mitochondria are always involved. There is no moment where the body “switches” from one system to another. What changes is the balance between glycolytic flux and mitochondrial capacity and lactate is the best real-time proxy of that balance. I proposed in 2013 a model based on substrate utilization. Now I propose an update of that model built around four metabolic states. From metabolic equilibrium at Zone 2 all the way to metabolic overload, where the central question is not what fuel you’re burning, but whether the system can sustain balance. Ultimately, the ceiling of equilibrium matters more than the ceiling of oxygen consumption. 👇 @inigosanmillan/note/p-193581258?r=2nunp3&utm_medium=ios&utm_source=notes-share-action" target="_blank" rel="nofollow noopener">substack.com/@inigosanmilla…


@Brady_H Wait till you find out you can make that gel for less than 10c by adding table sugar and salt to water.



@Alan_Couzens How does one make the heart “bigger”?




I was 16/17 in the summer of 1986. I could absorb a crap ton of volume going into my senior high school year. What if @stevemagness or @Alan_Couzens was my coach? The summer program: all runs at conversational pace with strides thrown in. If you are feeling frisky. Fartkleks


I'm a software engineer with 50 years of experience. If you know how to steer an LLM properly, the frontier models are extremely good at generating code. They're weak at architecture, which is one of several reasons you want a human in the loop, but they can have a very low error rate compared to most humans. When they don't - when they generate slop - it's because you didn't know how to use the tool correctly.



Your ability to move *is* your age. The deep squat is called “the anti-aging position”—one movement that improves strength and range of motion in the ankles, knees, hips, and lower back. Work up to 3 minutes each morning and I bet you’ll feel younger.

Everyone in the world has to take a private vote by pressing a red or blue button. If more than 50% of people press the blue button, everyone survives. If less than 50% of people press the blue button, only people who pressed the red button survive. Which button would you press?


Right now, because electricity prices keep going up, consumers have pinned this blame on AI Datacenters. This is unfair but there is no organized or concerted effort being put in to turn this tide. As the perception of AI and Datacenters grow increasingly negative, homeowners are protesting data center approvals at an alarming rate. It then flows through to cancelled projects. Currently, for every 100 projects that are protested, 40% get cancelled. As of March 2026, this will mean more than 40 projects this year alone which will be almost 9 GW. My prediction is that these cancellations will grow which will mean that the derisked capacity of AI will be meaningfully lower than what is needed. Lots of implications here but the most affected will be the Frontier Labs who need compute and as usage increases, will not be able to find capacity. Separately, the hyperscalers and neoscalers will be affected negatively. Finally, the chip/memory/asic/cpu ecosystem will then be hit as upstream customers cancel orders not because demand doesn't exist but the physical space to house and turn on their racks become fewer and farther between.


Everyone in the world has to take a private vote by pressing a red or blue button. If more than 50% of people press the blue button, everyone survives. If less than 50% of people press the blue button, only people who pressed the red button survive. Which button would you press?




This is largely true but the proportion is more like Coldstone mixin's. Sure the white chocolate raspberry ice cream is the star of the show, but you don't get to 100% without the Nestle Crunch Bar bits mixed in.














