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31 posts
Can faster heart rates ELEVATE lives?
In 30 years from bench to patient.
news.medtronic.com/2025-09-15-Med…
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Atria have a functional conduction system that is accessible for CSP
kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…
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Another way to give HFpEF patients more room to breathe
onlinelibrary.wiley.com/doi/10.1002/eh…
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2024 HCM Guidelines are failing HCM patients with preserved EF again!
BETABLOCKERS do NOT improve diastolic function. They are HFpEF in a pill.
Not indicated in nHCN
jacc.org/doi/10.1016/j.…
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@CircAHA Betablockers do not improve diastolic function = collective incompetence of the experts.
Not indicated in nHCN
jacc.org/doi/10.1016/j.…
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2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy #AHAJournals
ahajrnls.org/3UPk6Qd
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I can’t explain this observation. Seriously. I can’t.
JAMA Cardiology@JAMACardio
Most viewed in the last 7 days from @JAMACardio: Declines in HF-related mortality from 1999 to 2012 have been entirely undone by reversals from 2012 to 2021, meaning that contemporary HF mortality rates are higher than in 1999. ja.ma/3yduCaX
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@NicoleHabelMD @UVMLarnerMed @UVMMedCenter @lusty63 @MaggieInfeld Important first in HFpEF patients without standard PPM indication - EP Center of Excellence
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@JuliaSellerm @PatriciaPalau1 shouldn't we all have a bigger heart ?
Congrats team Patricia and Julio!
jamanetwork.com/journals/jamac…
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⏰PRESERVE-HR
➡️ Patients with HFpEF ➕ chronotropic incompetence
⛔️ β-blocker cessation may be particularly beneficial in patients with smaller end-systolic left ventricular volume @JAMACardio @PatriciaPalau1 @rdelaespriella @yulnunezvill
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@KramerWahlberg @UVMDeptMed @HRSonline @uvmcvri @nih_nhlbi @umichmedicine @MaggieInfeld Great new insights, Kramer !
Early signals that "rate shaping" of the LV may actually be feasible. More to come.
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@UVMDeptMed @HRSonline @uvmcvri @nih_nhlbi @umichmedicine Thank you for the shout out! This was an echocardiography substudy of the main myPACE RCT published last year in JAMA Cardiology and led by former UVM Cardiology and EP fellow, @MaggieInfeld . jamanetwork.com/journals/jamac…
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Exciting RCT from our dept! In #HFpEF pts w/ a pacemaker, Personalized Accelerated Pacing Rate (myPACE)⬆️quality of life, & physical activity,⬇️NT‐proBNP & AFib compared w/ pacing at 60 bpm. Lower diastolic filling pressures explain most benefits. tinyurl.com/2awtt2mc
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More background on personalized accelerated physiological pacing as a treatment approach for diastolic dysfunction.
doi.org/10.1093/eurhea…
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Are higher heart rates better in HFpEF ?jamanetwork.com/journals/jamac…
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@FudimMarat @lamcardio @AdriaanVoors @Jcontreras75 @novonordisk @HFpEF @KSharmaMD @udi_fainberg @CecilieHolse @markcpetrie20 @texhern Maybe not much inflammation in advanced HFpEF
ahajournals.org/doi/metrics/10…
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Tackling one of the proposed root causes of Heart Failure with Preserved Ejection Fraction (HFpEF): #Inflammation ⚡️
Very excited to be part of the HERMES trial and can’t wait to kick it off shortly! 🛫
IL-6 inhibition in patients with LVEF >40%, N=5,600, ~700 sites globally
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No evidence for inflammation in human myocardial LV transcriptome in advanced HFpEF
ahajournals.org/doi/abs/10.116…
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Without an evidence basis beta-blockers, remain the #1 drug prescribed in HFpEF (flawed rationale and outdated treatment recommendations)
authors.elsevier.com/a/1h0iu7tD%7EZ…
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@arnoldgehrke Without an evidence base beta-blockers remain the #1 medication class in HFpEF (due to a flawed rationale).
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Not all patients with “heart failure” need or benefit from beta blockers. Our analysis showing the potential for an increased risk for HF hospitalization with BB in patients with higher EFs (particularly over 60%). authors.elsevier.com/a/1h0iu7tD%7EZ…
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