Matthew Zaba

Larynx landmarks which might be useful (I find easier to correlate with compared to digital photos). #gross #larynx Pathological stage classification is based on location: supraglottis, glottis and subglottis. documents.cap.org/protocols/HN.L…

@smlungpathguy It’s primarily a language model

x.com/i/grok/share/L… I asked Grok: "what is this"? AI enthusiasts, how come this AI is not better than humans?

🔷Visceral pleural invasion🔷

@kis_lorand Percentage pattern 4/5: 100% 😆

Would you agree with grading this prostate cancer as Gleason score 4+5? #Gupath #pathology #PathTwitter

🟪Uterine myxoid leiomyosarcoma🟪 Macroscopic: ➡️Appearance is often gelatinous or glistening Histopathology: ➡️Myxoid stroma ➡️Vague fascicular growth Diagnostic criteria 🔬(1 or more of the following): ➡️Tumour necrosis ➡️Moderate to severe cytological atypia ➡️>1 mitosis per 10 HPF (0.55mm diameter field) ➡️Infiltrative margins Immunohistochemistry: ➡️Desmin ➡️SMA Take home point: ☑️Thorough sampling might be necessary to detect areas indicative of malignancy Image

#hemepath #lymsm pitfall 🚨 CLL proliferation centers typically show uprgularion of cyclin D1. Don’t confuse this w/ mantle cell lymphoma. There is no CCND1-r. Read more about CLL w/ proliferation centers in the BM in our paper in @Human_Pathology sciencedirect.com/science/articl…

Thoracic lesion, adult. #BSTpath #Pulmpath #pathresidents #pathtwitter

The serum free light chain FLC assay. Tutorial. #MedTwitter #MyelomaVR Frequently ordered and frequently abnormal. This thread will reduce unnecessary headaches and referrals. 1/ Don’t order it unless you are suspecting myeloma, amyloid or related disorder

@RZitwer Thanks Richard!

@Mattzaborowski1 Uterine myxoid leiomyosarcoma, desmin +. Beautiful images.

@JMGardnerMD I believe it’s this 😅😆 twitter.com/mattzaborowski…

A #pathology classic! Touch prep and H&E section. What's your diagnosis? Click here for answer with video: kikoxp.com/posts/3799 #Pathology #dermpath #dermatology #dermatologia #dermtwitter #BSTpath

🟠Leiomyoma of the broad ligament🟠 ☑️ circumscribed, firm mass ☑️ may develop prominent hydropic and degenerative cystic change ☑️ similar patterns and changes to its uterine counterpart, including criteria for malignancy

🩻Brain tumour, adult ~30s ⚕️Previous history of lower limb tumour ❓Questions in thread (Or just to answer below) kikoxp.com/posts/24507 #neuropath #bstpath #pathresidents #medtwitter #pathtwitter

So a new WHO book popped up online ⬇️➡️Genetic tumour syndromes 😅

pubmed.ncbi.nlm.nih.gov/32141887/ onlinelibrary.wiley.com/doi/abs/10.111… pubmed.ncbi.nlm.nih.gov/33234877/

🔵SYNOVIAL SARCOMA🔵 ✅ Low power blue tumour ✅ Monomorphic spindle cells +- epithelial component (monophasic or biphasic) 🧪IHC 🧪 ✅ SS18-SSX fusion specific antibody 🤌🤌 (picture below) ✅ SSX-CT 🧬Molecular🧬 ✅ SS18-SSX1 ✅ SS18-SSX2 ✅ rarely SS18-SSX4 🥼PROGNOSIS🥼 ✅ Aggressive ➡️ 10 year survival ~75% children/adolescents and ~50 adults

Subtype

Different area in the biopsy (2/2)

Twitter poll (x2) 📶📶 Recurrent Mantle cell lymphoma with a Ki67 70% ⬇️⬇️

@Cristina_VargAP Text book photos! 😅

#HemPath Today just ROSETTING in a Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL) 😍😍😍 IPXs are from left to right: PD1 & OCT2

Silica and silicates under polarized light: Both are needle-shaped and birefringent. Silicates are strongly birefringent. Silica is weakly birefringent but is associated with fibrosis. kikoxp.com/posts/24178