James Bayrer

Our true labor of love was published at Gastroenterology!! We showed: increased risk for the DGBI, functional constipation-matching our findings in Molecular Psychiatry and( 2) the gut may be a more targeted way to treat anxiety and depression! pubmed.ncbi.nlm.nih.gov/39658704/

RESEARCHER PROFILE Professor Stuart Brierley (Filmed February 2024) Director of the Visceral Pain Research Group, Director of the Hopwood Centre for Neurobiology & Theme co-Leader of Lifelong Health South Australian Health and Medical Research Institute (SAHMRI) @sahmriAU Professor Stuart Brierley is Director of the Visceral Pain Research Group, Director of the Hopwood Centre for Neurobiology, and Theme co-Leader of Lifelong Health at the South Australian Health and Medical Research Institute (SAHMRI) @sahmriAU. He has developed a strong track record in coordinating and working in multi-faceted research programs for high impact publications in journals. His work has attracted four NHMRC Fellowships including other @nhmrc and @NIH grants. The global pandemic has shed light on the severity of the Opioid Crisis, highlighting the urgent need for effective pain treatments. During his 24 years as a researcher, Professor Brierley has made significant strides in understanding how pain arises from the gastrointestinal tract or the gut. Prof Brierley is an international expert on the 'gut-brain axis' and chronic visceral pain mechanisms. Current investigations are on a individual cell type called the enterochromaffin cell, and it helps signal pain and anxiety from the gastrointestinal tract to the brain. His research comprises discovery and translational science investigating the nerve pathways innervating visceral organs to determine the causes of, and treatments for, Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), bladder pain syndrome, and endometriosis. Irritable Bowel Syndrome (IBS) and Inflammatory Bowel Disease (IBD) disorders are highly prevalent, affecting up to 15% of the Western population. Despite being a major global clinical issue, pain, especially from the gastrointestinal tract, lacks effective treatments, and the research focuses on understanding and treating pain in gastrointestinal diseases in order to develop targeted treatments. Individual gut cells communicate with the brain to signal pain and trigger symptoms that include depression and anxiety. Professor Brierley is collaborating with researchers in Australia and internationally including Nobel Prize winner Nobel Prize Laureate Professor David Julius @DJuliusSF, Professor Holly Ingraham @hollyingrahamSF and Dr Jim Bayrer @md_jrb at the University of California San Francisco @UCSF, all with the goal of helping people. His research interests extends into other common causes for visceral pain including interstitial cystitis/painful bladder syndrome and endometriosis and how ‘cross-organ sensitisation' can potentially explain co-morbidities in these patients. Pain is a global issue, and Professor Brierley’s work aims to understand its causes in order to develop targeted treatments, while also balancing a busy family life and various interests. SEE OTHER RESEARCHER PROFILES Bench Side Story benchsidestory.com

Ever wondered how diverse bowel functions are controlled? The key lies in its incredible array of diverse enteric neurons. Our analysis reveals some important challenges in their annotations and calls for taking a holistic approach. @FaranakFattahi biorxiv.org/content/10.110…

Ever wondered how diverse bowel functions are controlled? The key lies in its incredible array of diverse enteric neurons. Our analysis reveals some important challenges in their annotations and calls for taking a holistic approach. @FaranakFattahi biorxiv.org/content/10.110…

Congratulations to Dr. James Bayrer, our 2024 SPR New Member Outstanding Science Awardee! This award recognizes new members who have contributed to high quality scientific research & demonstrate meaningful contributions in the pediatric academic field. ow.ly/JgSB50Qgfh7

POSTDOC WANTED for The Bayrer Lab! We ❤️ guts: intestinal crosstalk, organoids, stem cell biology, gut/brain axis, gut/liver axis. For more information check out bayrerlab.ucsf.edu or email me James.Bayrer@ucsf.edu