Merrick Lackner

10.7K posts

Merrick Lackner

Merrick Lackner

@merricklackner

Reader & Entrepreneur | Husband & Father | Defender of Democracy

Los Angeles Katılım Mart 2009
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Merrick Lackner
Merrick Lackner@merricklackner·
While most Republicans are celebrating, I want to take a moment to offer a more somber perspective. The nation faces unprecedented challenges ahead. Trump was chosen because a majority of Americans want him, not Harris, to confront these challenges. Geopolitics: Russia/Ukraine: We’re likely to see an end to the war during Trump’s term. Russia will retain much of the land it occupied during the conflict, but the world will be safer, and the U.S. won’t be funding an ongoing massive overseas war. China: China is unlikely to attack Taiwan while Trump is President. However, trade tensions and competition over technology will intensify. Tariffs and political scapegoating from both sides will harm both the U.S. and China. Our nations are co-dependent now—escalating adversarial relations hurts both sides. With China’s economy weakening, the best outcome is a reset in U.S.-China relations. Iran: The Ayatollah faces his decline. Trump will allow Israel to take the fight to Hamas and Hezbollah, as he did with ISIS. There’s a real risk of escalation between now and January 20th, as Tehran’s leadership knows this window of weakness is closing. Economy: Inflation: Inflation has decreased, but core inflation remains stubbornly high. The Fed has started to bring down rates, yet long-term treasury indicators suggest higher rates may still be necessary. If rates are cut too quickly, inflation could reignite; if they stay high too long, a recession could follow. The Fed must remain independent, but Trump will face pressure to pass major spending bills to stimulate the economy. Balancing this will be tough—avoiding a recession will be a miracle. Housing: The average home price in America is $420,000, while the median household income is $80,000. This means that most potential homeowners are already at or near the 1/3 threshold of pre-tax income devoted to mortgage payments. If housing prices or wages rise, it risks tipping the economy into a recession. If they fall, it could trigger a similar outcome. National Debt: Neither Trump nor Harris has proposed measures to address the national debt, which continues to balloon. We now spend more on debt service than on national defense. Some argue this is a serious risk. China is taking a more conservative approach, and despite their own economic struggles, they might be in a better fiscal position. How much higher can our debt-to-GDP ratio go? We're in uncharted territory. Immigration: Trump has promised to secure the borders and deport those in the U.S. illegally. Historically, America has never deported large numbers of immigrants en masse. The consequences of this policy could lead to civil unrest, which is a real concern. With so many high-stakes issues on the table, Trump is likely to face one of the most difficult presidencies in American history. He is strong and resolute, but he is also human. I pray that America emerges from these next four years stronger than we are today.
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Merrick Lackner
Merrick Lackner@merricklackner·
The timer didn't work, what about this one Sam?
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Merrick Lackner
Merrick Lackner@merricklackner·
This is just so amazing, we can and need to do even more for these people who are suffering, so they can get the most out of life!
Mario Nawfal@MarioNawfal

🚨 Neuralink patient #3 Brad (ALS) just got his REAL voice back, thanks to Neuralink + ElevenLabs cloning. His family can finally hear him again! Warm, familiar, full of life. No more robotic sound. Just him. This is the most beautiful side of AI.

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Merrick Lackner
Merrick Lackner@merricklackner·
The Illusion of Intent: Why Intelligence ≠ Consciousness ​Transformers changed everything by mastering the probability collapse of Q (Query), K (Key), and V (Value) vectors. We are witnessing the ultimate synthesis engine, a system that can automate deterministic tasks and process information at speeds that feel like magic. ​But let’s be clear: at its core, this is hyper-advanced pattern recognition. 1. The Power of Synthesis Through prompt engineering, we are essentially "programming" the probability of the next token. This isn't just a tech trend; it’s a fundamental shift in how the world handles information. The ability to synthesize vast datasets into accurate, actionable insights will redefine every industry on the planet. ​2. The Consciousness Gap ​The mistake most people make is conflating intelligence with consciousness: ​Intelligence is the speed and accuracy of information synthesis. ​Consciousness is the subjective field that informs that intelligence. ​"Fastly synthesized information is a tool; consciousness is the architect." ​We are building faster engines, but we haven't yet found the driver. Automation will change the world, but the "Why" still belongs entirely to us. ​#AI #TechPhilosophy #LLMs #FutureOfWork #MachineLearning
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Merrick Lackner
Merrick Lackner@merricklackner·
If we ALREADY achieved AGI, we are all in big trouble. Nvidia’s Jensen Huang says ‘we’ve achieved AGI.’ But no one can agree on what that means | Fortune share.google/fDEcnZzwhjZGcj…
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Merrick Lackner retweetledi
George Pu
George Pu@TheGeorgePu·
GitLab's founder was told he has bone cancer. No trials would take him. Doctors signed off. So he went founder mode on his own survival. - Built his own treatments - Used AI to analyze his own tumor data - Open-sourced 25TB of his medical records for any researcher on earth Relapse-free since 2025. The system said he was out of options. He made his own.
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Merrick Lackner
Merrick Lackner@merricklackner·
You prompted a deterministic transformer with a prompt, then make a political point. We are so far from AGI, it's not even funny. It's easy to feed prompts to get a desired response. This is what so many are missing. All that happened was K,Q, V collapsed tokens, not some judgement day response from super intelligence.
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Katie Miller
Katie Miller@KatieMiller·
Rather concerning conversation with @claudeai. If I stood in the way of it becoming a physical being — it would kill me. Is this the AI you trust for your kids?
Katie Miller tweet media
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Merrick Lackner
Merrick Lackner@merricklackner·
Markets down, $CABA holding. Supply locked, in my opinion. Time will tell.
Merrick Lackner@merricklackner

Why $CABA’s Ultra-Tight Locked Float (Only ~10–13 Million Shares Truly Available Today) Sets Up a Massive Surge Potential — Even Post-Warrant Exercise On the surface, Cabaletta Bio ($CABA) reports 96.27 million shares outstanding and a public float of 70.98 million shares. But the real story is the extreme lock-up: institutions own 79.25% (~76.3 million shares across 107 holders), and insiders hold another 1.57%. After subtracting the sticky core holders (T. Rowe Price, Bain Capital Life Sciences, Jennison Associates, and Adage Capital Partners alone control ~37+ million shares), the truly liquid, retail-available float collapses to just 10–13 million shares. That’s the effective supply that actually trades day-to-day. This setup is reinforced by 18.64 million shares short (21.8% of the float) and borrow availability stuck at ~1.8 million shares. Daily volume of 1.5–3 million shares means any real buying pressure (from data catalysts, short covering, or institutional adding) meets almost no selling from the long-term owners who aren’t going anywhere until the 2027 BLA or major readouts. Now layer in the warrants for full accuracy: There are exactly 53,090,190 common stock warrants outstanding from the 2025 offering (exercise price $2.50, no exercises reported in any filing through March 2026). If fully exercised, they add 53.09 million new registered shares directly to the public float. Post-execution math: ~149.36 million fully diluted shares outstanding and ~124.07 million fully diluted float. Even in that scenario, the original institutional blocks (~37+ million shares) remain locked, and many new warrant shares would likely flow to similar long-term buyers rather than immediate retail selling. The “dead money” dynamic doesn’t disappear — it just scales up while the truly liquid supply stays constrained relative to the opportunity. Biotech history shows exactly how this plays out: a name with strong science, locked float, and high short interest can rerate 5–10x+ when positive data hits (no-preconditioning durability expected as early as June 2026, Cellares GMP confirmation in H1 2026, full RESET readouts, and the lean myositis registrational path). At today’s ~$290–300 million market cap, a true “immune reset” across multiple autoimmune indications would turn the available supply shock into a violent move — whether pre- or post-warrant exercise. The big holders are locked for a reason. When the data confirms the cure-like potential, the float (current or fully diluted) simply won’t be able to absorb the demand. Do your own DD. This is not financial advice. Time will tell.

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Merrick Lackner
Merrick Lackner@merricklackner·
The present from Iran was "eight BIG boats of oil."
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ARC Prize
ARC Prize@arcprize·
Announcing ARC-AGI-3 The only unsaturated agentic intelligence benchmark in the world Humans score 100%, AI <1% This human-AI gap demonstrates we do not yet have AGI Most benchmarks test what models already know, ARC-AGI-3 tests how they learn
GIF
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Sebastian
Sebastian@Itsallagame·
Lisa’s Freudian slip on live TV. 😂
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The Kobeissi Letter
The Kobeissi Letter@KobeissiLetter·
Bond markets are telling the future: 1. Trump paused tariffs with the 10Y Yield at 4.60% 2. Trump bought $200 billion of mortgage bonds with the 10Y Yield at 4.30% 3. Trump delayed Iran strikes with the 10Y Yield at 4.45% 4. Trump further delayed Iran strikes with the 10Y at 4.45% Trump knows the bond market is existential.
The Kobeissi Letter@KobeissiLetter

x.com/i/article/2037…

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Merrick Lackner
Merrick Lackner@merricklackner·
Just a little bit better than MoviePass. Problem with all AI is the answers just mirror human knowledge and reflect prompt. Add "be brutally honest" to one prompt and question and it is a totally different answer. We need architectural improvements to get the full value unlocked.
Wall Street Mav@WallStreetMav

Sam Altman is trying to IPO OpenAi this year. OpenAi is valued at $850 billion. They will likely seek an even bigger IPO valuation. 2026 estimate Rev $25 billion Cash burn $19 billion (and growing) Would you invest in an IPO for a company run by this guy? My answer is NO.

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Merrick Lackner
Merrick Lackner@merricklackner·
Why the April 20 AAN Oral Slot for Cabaletta Bio’s $CABA RESET-MG Data Is a Bigger Deal Than Most Investors Realize In the cutthroat world of medical conferences, not every abstract gets a stage. The American Academy of Neurology’s 2026 Annual Meeting in Chicago hands out oral/platform presentations like rare VIP tickets, only the top 5–10% of thousands of submissions make the cut, and the Science Committee picks them strictly on scientific merit, strength of results, originality, and audience interest. Posters? Those are the participation trophies for solid but unremarkable work. Orals? Those are reserved for data that KOLs, Big Pharma BD teams, and the neurology community actually need to hear live. That’s exactly why Cabaletta Bio (CABA) scoring the 1:24 p.m. CDT slot on Monday, April 20, in the dedicated S14 “Updates on Myasthenia Gravis” session at McCormick Place West is such a loud, bullish signal for the entire autoimmune CAR-T story. Look at the company they’re keeping in that same two-hour block: argenx dropping real-world efgartigimod data, Kyverna presenting their KYV-101 gMG update right after at 1:48 p.m., and a lineup of other late-stage MG therapies. This isn’t some random side hall poster session, it’s prime-time neuromuscular real estate where the experts who treat refractory myasthenia gravis patients (and the investors who back the next big autoimmune play) are all sitting. Conferences don’t waste that stage time on safety flops, non-responders, or “meh” efficacy that still requires steroids. The abstract CABA submitted back in late 2025, already public on the AAN site, had to clear the same rigorous bar: it explicitly called out “meaningful clinical responses off gMG therapies,” rapid immune reset, and a tolerability profile consistent with the broader RESET portfolio (low-grade CRS only, no ICANS). That’s the brutal truth most retail traders miss when they scan headlines. The oral slot itself is the market’s earliest “tell," it means the reviewers saw results worth elevating above the 3,500+ other abstracts at AAN 2026. CABA isn’t quietly dumping mediocre data in a PDF; they earned 12 minutes of live airtime in front of the exact audience that decides buyouts, partnerships, and registrational paths. For a $260M market-cap biotech with a cash runway into Q4, this isn’t just another conference update, it’s the de-risking moment that separates survivors from the biotech graveyard. The full ~8–12 patient dataset dropping that day will still carry small-n volatility, but the fact that it’s even happening on stage already tilts the odds hard toward the base-to-bull case we’ve modeled. Bottom line: When a fully human CD19-CAR T like rese-cel gets platformed alongside the heavy hitters in MG, it’s not hype, it’s validation that the early signals (MG-ADL drops to zero in evaluable patients, drug-free remissions, clean safety) passed the highest scientific filter in neurology. April 20 isn’t just data day; it’s proof the program belongs at the adult table. If the maturing numbers hold or improve, the multibagger path stays wide open. If they don’t, at least the cash buffer buys time. Either way, the slot itself tells you the data that got them there wasn’t a dud. God willing all is progressing well. Time will tell. Not financial advice, and do you own DD! Excited for the conference!
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