Marcos G. Teneche

Senescent cells secrete chromatin components via senescence-associated extracellular particles --- New study from recently graduated PhD student in the lab, Lana Zaretski, co-supervised by Malene Hansen @thehansenlab and myself. Great job, Lana! biorxiv.org/content/10.648…

For this MS, super post-doc Hiroshi Tanaka chose to manipulate nucleosome stability and assess impact on cell identity, resilience and aging. The data support that idea that nucleosome stability promotes phenotypic maintenance and healthy aging. biorxiv.org/cgi/content/sh…

New @NatureGenet review from our NIH SenNet ⁦@sennetresearch OMICS WG co-led by ⁦@shenglilab⁩ ⁩ We share practical considerations for identifying, characterizing & spatially mapping #CellularSenescence, plus computational #multiomics insights!! nature.com/articles/s4158…

I'm excited to share this new MS led by fabulous PhD student Adarsh Rajesh "Targeting Cyclin D1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline". biorxiv.org/cgi/content/sh…

Venoms can kill, but can they also heal? Here's Episode 3 of The Discovery Dialogues Podcast 𝗬𝗼𝘂𝗧𝘂𝗯𝗲: tinyurl.com/u7p3r8n9

I'm excited to finally share this work led by @FarahJaberH : Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells. Published in Aging Cell. doi.org/10.1111/acel.7…

In Episode 2 of the Discovery Dialogues Podcast, we recount the fascinating story of the race to clone the first human gene. Featuring Herb Boyer and Keiichi Itakura. YouTube: tinyurl.com/4x7fkzzu

🚨 Calling senescence researchers! Applications are open for the #ICSARome2025 DEI & @YicsaC Travel Fellowships 🌍✈️ Need-based & merit-based awards available to attend our annual meeting in Rome 🇮🇹 🗓️ Deadline: May 15 🔗forms.gle/GP3UcottiobZAf… & forms.gle/737JLKEVRAfGdr…

📢 Join our next #yICSA Webinar! 🔬 Silvina Sonzogni will discuss her career, senescence research, & challenges of building a research career in Latin America. 📅 March 28, 12:00 CET 🔗 Register: us06web.zoom.us/meeting/regist… #yICSAWebinarSeries

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells nature.com/articles/s4146…

Now online, the main paper from my postdoc! A huge thank you to my coauthors, the Adams lab, and Peter @AdamsBioAging nature.com/articles/s4146…

With great joy! I want to share with you our recent work on how Bile acid synthesis impedes tumor-specific T cell responses during liver cancer | Science thanks to all the authors and ⁦@Tcellogic⁩ ⁦@salkinstitute⁩ science.org/doi/10.1126/sc…

Nature research paper: FBP1 controls liver cancer evolution from senescent MASH hepatocytes go.nature.com/3VXdlMb

Our institute is excited to host The Myeloid Precursor this Thursday, a fun mini symposium on AML with great talks, a panel discussion on AML, and a poster session. If you are in San Diego this Thursday and interested, please register here. forms.office.com/r/Sq59VV1vh7

🚀 We're thrilled to announce the launch of the #yICSAWebinar Series, connecting young scientists in the field of senescence! 🌍 Check out our introduction video to learn more about what’s coming up! 🎥 youtu.be/l7FSoz2qWig?si…

@ChristiDemet @AACR @WellenLab @mzspectrum Congratulations!!!!!!

Soooo excited and honored to receive the @AACR - Anna D. Barker fellowship that will support my research on uncovering a new link between #metabolism and #epigenetics in #PDAC. Many thanks to my amazing mentors @WellenLab @mzspectrum for making this possible. Stay tuned!!!

New study led by talented post doc in the lab @Aaron_Havas : 1) aged tissues at increased risk of cancer due to "precarious balance"; 2) age-activated IFN signaling is an adaptive response to prevent cancer in older tissues, but w/ maladaptive consequence. tinyurl.com/2k4nzs49

Last day to apply! Don't miss it ✈️✈️

📢✨I am thrilled to share that my work from my PhD is now out!  Our ❔ was why the cytokine Interleukin-6 (IL-6) can induce senescent in some cells and proliferation in others? 🧵👇

Excellent meeting : Molecular and Cellular Aging, Sept 10-11, 2024, Estancia Hotel, La Jolla, CA. Registration link coming soon!! Save the data and please circulate.