Milan Savani

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice dlvr.it/TSHkdW

Brain cells refine nitrogen choice with maturity dlvr.it/TSHkl5

@Sorrell_Lab @CRI_UTSW Thanks so much!

@CRI_UTSW @milan95 Congratulations Sam and Milan!

Head over to 🦋 for the full science 🧵 from @milan95 👉bsky.app/profile/milans… #relentlessdiscovery

ONLINE NOW in @NatMetabolism: McBrayer Lab & first-author @milan95 have discovered cell maturity determines pyrimidine synthesis pathway preference using their new nitrogen metabolism profiling platform, organoid model. Read more ⬇️ cri.utsw.edu/cell-maturity-… #relentlessdiscovery

Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth biorxiv.org/content/10.110… #biorxiv_cancer

My postdoc preprint is online now! We revealed GSX2 as a target of mutant IDH in glioma. Check full text below.

@WalterWChen1 @NatureCellBio @dwendscheck @warscheidlab Congratulations, Walter!!!

Our paper on discovering a new paradigm in peroxisome biogenesis and PEX39 (1st human peroxisomal biogenesis protein found in > 20 yr) is out in @NatureCellBio! Wonderful, equal collab with Tony Rodrigues, @dwendscheck, Jorge Azevedo, @warscheidlab #ref-CR49" target="_blank" rel="nofollow noopener">nature.com/articles/s4155…

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice biorxiv.org/content/10.110… #biorxiv_cellbio

Today's #MondayMotivation is courtesy CRI's McBrayer Lab: Congrats @milan95 for successfully defending your dissertation! Dr. Savani's family and lab mates joined to celebrate. Next steps: publishing his #research & finishing his M.D. @UTSWMedCenter 🎉 #relentlessdiscovery

Collab🚨: CRI's McBrayer Lab contributed to a discovery published in @ScienceMagazine from @MangusoLab & Bardeesy Lab at @MGHCancerCenter that defines a new #cancer-causing mechanism associated with IDH1 mutations (the most commonly mutated metabolic gene across cancers). From Sam McBrayer, Ph.D.: "They found that IDH1 mutations repress expression and sensing of transposable viral elements in the genome that can trigger innate immune signaling in brain and liver cancers. "Drugs that inhibit IDH1 mutant enzymes can reverse this process, leading to anti-tumor immune responses. These findings provide new insights into how IDH1 mutations, as well as drugs that target these mutations, regulate cancer growth." Read it here: science.org/doi/10.1126/sc… #relentlessdiscovery #CancerResearch

New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/sc… #CancerResearch #Cholangiocarcinoma #IDH1 1/n

Our lab is hiring at all levels! We’ve got multiple cool projects looking at metabolism, placenta biology, chromatin regulation. Click here to read more: labs.utsouthwestern.edu/solmonson-lab And email me at Ashley.solmonson@utsouthwestern.edu if you are interested!

@minakimes @QBKlass

NEW POD! Previewing week one w @QBKlass: -What happens if Kelce can’t play? -Bosa’s return -How should NE defend PHI -Can Burrow evade an improved CLE D line? -LAC MIA, DAL NY and more! Also—picks for every game! Subscribe here: apple.co/2RV6YWp

In the latest edition of @CellPressNews Trends in Cancer, the McBrayer lab at @CRI_UTSW reviews the emerging roles that nucleotides play in cancer metabolism. Learn more at sciencedirect.com/science/articl…

Excited to share our new review covering recent work on nucleotide metabolism in cancer! Free access link here: authors.elsevier.com/a/1h2%7E0_sivv…

@yesajett @boominonion

NEW content online! Gliomas lean on pyrimidines dlvr.it/SYkf3S

The September issue of Cancer Cell is out! Read and spread the news: cell.com/cancer-cell/is…

Was great to have the chance to present our recent work from the McBrayer lab at #KSTumorMetabolism22 – thanks to the organizers, Sam, @RJDLab, our collaborators, and everyone at @CRI_UTSW! Check out the paper at doi.org/10.1016/j.ccel…