mimetic

@DInclinic Scrub machine? That’s always the thing that gets me in the end.

Peak residency is being able to make it through an entire day at work in a hospital full of badge access doors when you forgot your badge at home. Bonus points for getting in the parking garage without. #orthotwitter #medtwitter

@ConnyCurrently The guy on the right has been humbled.

So, what’s the difference? #cdnpoli #LiberalMinority #justintrudeau

@RachelAlter007 LIES!

@DavidJuurlink Yup.

Just did an antigen test in anticipation of travel. Fast, painless, inexpensive (presumably dirt cheap at scale.) Hard to believe we aren’t deploying these much more widely than we are.

@TWilsonOttawa @Schonsmom Apropos of nothing, this comes out next week. amazon.ca/Indian-Cabinet…

Trudeau made a major misstep with Annamie Paul. She called him out for being a fake feminist. Name dropped and then he cut her off by saying “I’ll take no lessons from you”. He was condescending. Women will not like it… @Schonsmom 👈🏻🗳🇨🇦 #Debate2021 #Elxn44

@jeff_aikman @LFPress Calling it an “experimental vaccine” pretty much guarantees it.

A tearful Western University professor says she refuses to take the #COVID19 vaccine and compares herself to Socrates – "who was executed for asking questions" – as she contemplates being fired by the school, which has made vaccination mandatory. tinyurl.com/3nkbrahf #ldnont

@ConnyCurrently I swear, there’s no reason this should still be news. And yet…the myth continues.

Or ceftriaxone and ceftazidime:

@TakeThatCDC @RRCampbell @MartinKulldorff @Harvard @harvardmed @BrighamWomens @HarvardChanSPH Can’t resist…

@DarthMods @gorskon What sources? I see none. I do see this tho: “Errors are said to be the third leading cause of death in Canada after cancer and heart disease.” Strong stuff. “Are said to be.”

No. Medical error is NOT the 3rd leading cause of death. Not even close. Ironically, that claim has been popularized by someone who now denies the severity of #COVID19 and the efficacy of vaccines, Marty Makary.

I've been talking about ivermectin a bit recently, and every time I mention it someone will link me to this odd website - ivmmeta dot com So, a bit of a review. I think this falls pretty solidly into the category of pseudoscience 1/n

@drgomulka @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK Yes, a low event rate in any single study as it pertains to the validity of the result is a fair critique. I’d have to look back to see how they powered the study and what estimated effect size they were using. Still looking at the totality of the evidence though.

@mimetic_ @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK That study could not get to statistically significant results, because the patients in it were too healthy and did not generate enough hospitalization events. We can't get to anything meaningful when treatment has 8/214 and control has 11/227. We could with 80/214 vs 110/227.

Today's ivermectin paper excluded 30% of their control group after randomisation because, and I kid you not, the people REACHED THE PRIMARY ENDPOINT TOO QUICKLY 🤯🤯🤯

@drgomulka @OutOfTheDarkAge @CodingMonkey @swedishchf @GidMK Already has been giving to thousands in RCTs. If it’s at all effective, presumably the positive effect must be exceedingly modest and thus would never be reliably detected in trials without enormous sample sizes.

@mimetic_ @OutOfTheDarkAge @CodingMonkey @swedishchf @GidMK Then don't give it to millions, I agree. Give it to hundreds or thousands as part of a large state-sponsored trial. We can get to millions after that, if the results hold up.

@drgomulka @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK Yes, imprecise. Notably stopped early for futility. That study was given as an example to demonstrate that it had been studied in outpatients, look at everything together. Where is the convincing evidence of effect?

@mimetic_ @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK Again about that study: it had low numbers of events, but the main HR that they put on the graphic said HR=0.76. That literally means "it's somewhat working and will save a quarter of patients from hospitalization". But The CI was so wide that the real HR can be anywhere.

@drgomulka @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK Specifically who the skeptics are in your tweet.

@drgomulka @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK Expand on this, not sure I completely follow your point.

@OutOfTheDarkAge @drgomulka @CodingMonkey @swedishchf @GidMK If by some miracle something comes out that suggests benefit in some segment of the population, I’ll happily get on board. Until that time, “there’s a small chance they could be wrong” is not a reason to start giving millions upon millions of people a drug.

@mimetic_ @drgomulka @CodingMonkey @swedishchf @GidMK Well, given the very high cfr/ifr and long-COVID cases in the USA/UK, the authorities in these nations could be wrong. And I say this as an Indian having gone through Kappa

@drgomulka @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK Meanwhile you seem to be suggesting a treatment based on nothing but the feels at this point. I’ll remind you that I jumped in when you erroneously suggested HCQ had only been studied in in-patients. Maybe you need to have another look at the literature.

@drgomulka @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK And for the record, I’m well aware of the issues that arise from concentrating on 95% CIs alone in the medical literature when labeling something dichotomously as “effective” or “not effective”. Doesn’t change my point one bit.

@drgomulka @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK They just happen to be right. Weird, I know.

@mimetic_ @CodingMonkey @OutOfTheDarkAge @swedishchf @GidMK Appeal to Authority.